... in ubiquitination is less clear. Deubiquitinating enzymes (DUBs) counteract ubiquitination and provide an important regulatory aspect to many signalling pathways involving ubiquitination. In this review, we look at the complex network of ubiquitination and deubiquitination in controlling HIF signalling in normal...

...Karin Vogel; Erika Isono The regulation of ubiquitylation is key for plant growth and development, in which the activities of ubiquitylating enzymes as well as deubiquitylating enzymes (DUBs) determine the stability or function of the modified proteins. In contrast with ubiquitylating enzymes...

... to be displaced from chromatin. L3MBTL1 is K48 ubiquitinated by RNF8 and extracted by VCP/p97 from chromatin [ 73 ]. This ubiquitination is antagonised by OTUB2, a DUB that is recruited to DSBs and slows L3MBTL1 Ub dependent removal from chromatin. This limits excessive 53BP1 spreading [ 37 , 75 ]. SUMOylation...