... an archetypal cell division. Studies of development of many different organs in different species have demonstrated that this stereotypical cell cycle is often subverted to produce specific developmental outcomes, and examples from over 100 years of analysis of the development of Drosophila melanogaster have...

... formation, and investigations using the embryo of the fruit fly Drosophila melanogaster have been crucial in elucidating their dynamics. However, a full understanding of how these components interact has been hampered by the total absence of centrioles in null mutant backgrounds for any of these core...

... division to drive neurogenesis and brain development. Many of the genes, pathways, and developmental paradigms that dictate NSC development in humans are conserved in Drosophila melanogaster . As such, studies of Drosophila NSCs lend invaluable insights into centrosome function within NSCs and help inform...

... to determine a complete picture of the different forms of chromatin present within a cell. In the fruit fly, Drosophila melanogaster , the study of chromatin states has been aided by the use of complementary and cell-type-specific techniques that profile the marks that recruit chromatin protein binding...

...Oliver M. Rogoyski; Jose Ignacio Pueyo; Juan Pablo Couso; Sarah F. Newbury Genomic analysis has found that the transcriptome in both humans and Drosophila melanogaster features large numbers of long non-coding RNA transcripts (lncRNAs). This recently discovered class of RNAs regulates gene...

.... However, I also discuss examples where integrins inhibit the BMP pathway, highlighting the context-dependent nature of integrin–BMP cross-talk. BMP signalling Drosophila melanogaster extracellular matrix integrins Smad Within a tissue environment, a cell will typically be receiving...

..., this mini review will focus on the HF mechanisms associated with mechanical forces and how a simple in vivo model, such as fruit fly ( Drosophila melanogaster ), may aid the studies using an empirical data-based in silico approach. Drosophila melanogaster heart failure integrins mechanical...

... for the cellular abnormalities seen in HGPS, the mechanism linking progerin to the organismal phenotype is not fully understood. To begin to address the mechanism behind HGPS using Drosophila melanogaster , we have ectopically expressed progerin and lamin A. We found that ectopic progerin and lamin A phenocopy...

...Anuja Mehta; Abhyuday Deshpande; Fanis Missirlis Ferritin, a symmetrical 24-subunit heteropolymer composed of heavy and light chains, is the primary iron-storage molecule in bacteria, plants and animals. We used a genetically engineered strain of the model organism Drosophila melanogaster which...

... 2006 The Biochemical Society 2006 cytochrome P450 (CYP) Drosophila melanogaster evolution insect genome mitochondrion phenobarbital Insects as an ancient (>450 million years) taxonomic group have the largest number of macroscopic species, both described (∼60%) and predicted...

... were first uncovered in the fruit fly Drosophila melanogaster , whereas cockroaches were among the first animals where the brain master clock was localized. Despite many similarities, there exist obvious differences in the organization and functioning of insect master clocks. These similarities...

... AMPKK, AMPK kinase CPT, camitine palmitoyltransferase DmACC, Drosophila melanogaster ACC DmAMPK, Drosophila melanogaster AMPK dsRNA, double stranded RNA HMG, 3-hydroxy-3-methylglutaryl PKA, cAMP-dependent protein kinase ZMP, S-aminoimidazole-4-carboxamide ribonucleoside monophosphate...

... and of circulating peptide hormones in insects and nematodes. A family of neprilysin-like genes are present in the genomes of both Drosophila melanogaster and Caenorhabditis elegans ; in C. elegans it seems that individual family members have evolved to take on different physiological functions, because...