...Ethan Thibault; Federica Brandizzi Homeostasis of the endoplasmic reticulum (ER) is critical for growth, development, and stress responses. Perturbations causing an imbalance in ER proteostasis lead to a potentially lethal condition known as ER stress. In ER stress situations, cell-fate decisions...

... protein response (UPR) is necessary. UPR followed by cell surface exposure of calreticulin on the dying tumor cell is essential for its engulfment by macrophages and dendritic cells. However, some tumor cells upon endoplasmic reticulum (ER) stress can release factors that induce ER stress to other cells...

... with Portland Press and the Biochemical Society under a transformative agreement with JISC. DDR ER stress hypoxia radiation replication stress UPR Oxygen homeostasis in eukaryotes is essential in order to maintain aerobic metabolism and intracellular bioenergetics. Due to the high...