... are endocytosed after ligand binding. Many internalized receptor–ligand complexes and numerous other endocytosed proteins arrive at the Rab5-positive early endosome, where they will be sorted. Cargoes marked with ubiquitin are bound by endosomal sorting complex required for transport (ESCRT)-0 and ESCRT-I...

...Christophe Caillat; Sourav Maity; Nolwenn Miguet; Wouter H. Roos; Winfried Weissenhorn The endosomal sorting complex required for transport-III (ESCRT-III) and VPS4 catalyze a variety of membrane-remodeling processes in eukaryotes and archaea. Common to these processes is the dynamic recruitment...

... face of the endosome and generates vesicles that bud into the endosome lumen, but somehow escapes encapsulation itself. This machinery is termed the ESCRT (endosomal sorting complexes required for transport) pathway, a series of multi-protein complexes and accessory factors first identified in yeast...

[email protected] ) 14 3 2018 2 5 2018 4 5 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 autophagy ESCRT nuclear envelope nuclear pore complex nucleus Torsin Alterations to the shape of the nucleus is a hallmark...

...Marisa S. Otegui The degradation of plasma membrane and other membrane-associated proteins require their sorting at endosomes for delivery to the vacuole. Through the endocytic pathway, ubiquitinated membrane proteins (cargo) are delivered to endosomes where the ESCRT (endosomal sorting complex...

...Edward J. Scourfield; Juan Martin-Serrano The vast expansion in recent years of the cellular processes promoted by the endosomal sorting complex required for transport (ESCRT) machinery has reinforced its identity as a modular system that uses multiple adaptors to recruit the core membrane...

... downstream signalling and tumorigenesis. Since the E ndosomal S orting C omplexes R equired for T ransport (ESCRT) controls these processes, ESCRT components were proposed to act as tumour suppressor genes. However, the bona fide role of ESCRT components in tumorigenesis has not been clearly demonstrated...