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Keywords: Fab1
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Articles

The amyloid precursor protein (APP) binds the PIKfyve complex and modulates its function

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Heather Currinn, Thomas Wassmer
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 185–190.
https://doi.org/10.1042/BST20150179
Published: 09 February 2016
... 11 2015 © 2016 Authors; published by Portland Press Limited 2016 amyloid precursor protein PIKfyve phosphatidylinositol-3 5-bisphosphate trafficking Alzheimer's disease Vac14 Fig4 Fab1 Phosphoinositides are important components of cellular membranes. What sets them apart...
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Articles

Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time

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Natsuko Jin, Michael J. Lang, Lois S. Weisman
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 177–184.
https://doi.org/10.1042/BST20150174
Published: 09 February 2016
... to stimuli. A large complex of proteins that includes the lipid kinase Fab1–PIKfyve, dynamically regulates the levels of PI(3,5) P 2 . Deficiencies in PI(3,5) P 2 are linked to some human diseases, especially those of the nervous system. Future studies will probably determine new, undiscovered regulatory...
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