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Keywords: G protein
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Biochem Soc Trans (2016) 44 (2): 562–567.
Published: 11 April 2016
...Andrew M. Ellisdon; Michelle L. Halls With >800 members, G protein-coupled receptors (GPCRs) are the largest class of cell-surface signalling proteins, and their activation mediates diverse physiological processes. GPCRs are ubiquitously distributed across all cell types, involved in many...
Biochem Soc Trans (2013) 41 (1): 218–224.
Published: 29 January 2013
...Eamonn Kelly Ligand bias refers to the ability of a drug at a receptor to activate selectively particular cell signalling pathways over others, in a way that cannot be explained by traditional models of receptor theory. For a physiologically and therapeutically important GPCR (G-protein-coupled...