... messenger concentration. cAMP and kinase activity reporter probes have provided powerful tools for the study of localized signals. Studies relying on these and related probes have the potential to further revolutionize our understanding of G protein-coupled receptor signaling systems. Unfortunately...

...Monica Napolitano The G protein-coupled receptors (GPCRs) constitute a large superfamily of seven transmembrane-spanning receptors that are activated by several classes of ligands, including bioactive lipids. GPCRs are attractive therapeutic targets for the treatment of human diseases...

... correspondence should be addressed (email [email protected] ). 25 11 2015 © 2016 Authors; published by Portland Press Limited 2016 biased signalling drug discovery G protein-coupled receptors pepducins polypharmacology Figure 2 Pepducin polypharmacology Pepducins...

... (G-protein-coupled receptors), the existence of protein aggregates such as oligomers or clusters has been the topic of extensive debate. One of the reasons for this lively argument is that the molecular size is below the diffraction-limited resolution of the conventional microscopy, precluding...