... that enhances the sexual behaviour of female mice via the VNO. NMR studies demonstrate that ESP1 adopts a compact structure with a helical fold stabilized by an intramolecular disulfide bridge. Functional analysis in combination with docking simulation indicates that ESP1 is recognized by a specific G-protein...

...Markus Milde; Ruth C. Werthmann; Kathrin von Hayn; Moritz Bünemann A wide variety of G-protein-coupled receptors either activate or inhibit ACs (adenylate cyclases), thereby regulating cellular cAMP levels and consequently inducing proper physiological responses. Stimulatory and inhibitory G...

...Robert A. Arkowitz; Martine Bassilana Rho G-proteins and phosphatidylinositol phosphates, which are important for exocytosis, endocytosis and cytoskeleton organization, are key regulators of polarized growth in a range of organisms. The aim of the present brief review is to highlight recent...

...Sophie Mary; Jean-Alain Fehrentz; Marjorie Damian; Pascal Verdié; Jean Martinez; Jacky Marie; Jean-Louis Banères The dynamic character of GPCRs (G-protein-coupled receptors) is essential to their function. However, the details of how ligands and signalling proteins stabilize a receptor conformation...

... are supported by G-protein-independent, β-arrestin-dependent signalling events. In the present article, we review current knowledge on structural and signalling properties of ACRs that are changing our view on this entire class of receptors from silent to endogenous β-arrestin-biased signalling receptors...

...Eoin E. Kelly; Conor P. Horgan; Bruno Goud; Mary W. McCaffrey Intracellular membrane trafficking requires the complex interplay of several classes of trafficking proteins. Rab proteins, the largest subfamily of the Ras superfamily of small G-proteins, are central regulators of all aspects...

... are compared with recently published X-ray crystallographic structures of activated GPCRs (G-protein-coupled receptors). These molecular dynamics-based models using experimental data derived from biophysical experiments on activation were used to restrain the receptor to an active state that gave high...

... and adipoQ receptors), which include receptors for adiponectin in vertebrates and osmotin in fungi. mPRs have been shown to activate inhibitory G-proteins, suggesting that they act as GPCRs (G-protein-coupled receptors). However, PAQRs do not resemble GPCRs with respect to topology or conserved sequence...

... of the subunit joining step of the process. 1 To whom correspondence should be addressed (email [email protected] ). 10 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 G-protein initiation factor ribosomal subunit joining translation initiation In all...

...Sarah S. Mohammad-Qureshi; Martin D. Jennings; Graham D. Pavitt A variety of cellular processes rely on G-proteins, which cycle through active GTP-bound and inactive GDP-bound forms. The switch between these states is commonly regulated by GEFs (guanine-nucleotide-exchange factors) and GAPs (GTPase...

... and the heterotrimeric G-proteins GOA-1/GPA-16 and their regulator GPR-1/2 causes defects in aster-positioned cytokinesis but not in midzone-positioned cytokinesis. In order to understand aster-positioned cytokinesis we have to understand how microtubule asters spatially control the activity of LET-99, GPR-1/2 and GOA-1...

...M. Sato; D.S. Hutchinson; B.A. Evans; R.J. Summers Localization of G-protein-coupled receptors within membrane microdomains is associated with differential signalling pathway activation. We have shown that two mouse β 3 -AR (β 3 -adrenoceptor) isoforms encoded by alternatively spliced mRNAs differ...

...A.C. Conner; J. Simms; J. Barwell; M. Wheatley; D.R. Poyner The receptor for CGRP (calcitonin gene-related peptide) is a heterodimer between a GPCR (G-protein-coupled receptor), CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity-modifying protein 1). Models...

...A.D. Strosberg; C. Nahmias This short review provides a broad, and therefore necessarily incomplete and personal, overview of G-protein-coupled receptors, which are often targets for a wide range of important drugs: I will discuss successively their structure, function and interactions...

...S.C. Tovey; S.G. Dedos; C.W. Taylor PTH (parathyroid hormone), acting via type 1 PTH receptors, is a major regulator of plasma [Ca 2+ ]. The G-protein, G s , is an essential component of the sequence linking PTH to plasma Ca 2+ regulation, but the relative importance of intracellular signals...

... by which mTOR controls 4E-BP1 and eEF2 kinase and the control of ribosomal protein translation. 1 email [email protected] 14 9 2005 © 2006 The Biochemical Society 2006 eukaryotic initiation factor (eIF) G-protein insulin mRNA translation mammalian target of rapamycin...

...B. Antonny; J. Bigay; J.-F. Casella; G. Drin; B. Mesmin; P. Gounon The GTP switch of the small G-protein Arf1 (ADP-ribosylation factor 1) on lipid membranes promotes the polymerization of the COPI (coat protein complex I) coat, which acts as a membrane deforming shell to form transport vesicles...

...C.S. Hoffman The fission yeast Schizosaccharomyces pombe primarily detects glucose via a cAMP-signalling pathway. Components of this pathway include the Git3 G-protein-coupled receptor and a heterotrimeric G-protein, from which the Gpa2 Gα subunit activates adenylate cyclase (Git2/Cyr1). Three...

...G. Milligan; H. Murdoch; E. Kellett; J.H. White; G.-J. Feng A substantial number of G-protein-coupled receptor-interacting proteins have been identified initially by the use of yeast two-hybrid screens. Using the C-terminal tail of both opioid receptors and the melanin concentrating hormone...

... 2004 adhesion G-protein integrin αIIbβ3 phosphoinositide 3-kinase (PI 3-kinase) phospholipase Cγ2 platelet Abbreviations used: CRP, collagen-related peptide; GPIb (etc.), glycoprotein Ib (etc.); ITAM, immunoreceptor tyrosine-based activating motif; PAR, protease-activated receptor...

... 6 September 2002 Copyright 2003 Biochemical Society 2003 G-protein G-protein-coupled receptor rhodopsin Abbreviations used: ACh, acetylcholine; mAChR, muscarinic acetylcholine receptor; NMS, N -methyl scopolamine; TM, transmembrane. Signalling the Future 29 Structure...

... be addressed (e-mail [email protected] ) 13 3 2002 © 2002 Biochemical Society 2002 ADP-ribosylation factor G-protein phospholipases C/D pituitary adenylate cyclase-activating polypeptide (PACAP) vasoactive intestinal polypeptide (VIP) ARF, ADP-ribosylation factor ERK...