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Keywords: G-protein-coupled receptor (GPCR)
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Articles

Using the fragment molecular orbital method to investigate agonist–orexin-2 receptor interactions

Alexander Heifetz, Matteo Aldeghi, Ewa I. Chudyk, Dmitri G. Fedorov, Mike J. Bodkin, Philip C. Biggin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 574–581.
https://doi.org/10.1042/BST20150250
Published: 11 April 2016
...-based drug discovery (SBDD) process. Clearly, to begin SBDD, a structure is needed, and although there has been fantastic progress in solving G-protein-coupled receptor (GPCR) crystal structures, the process remains quite slow and is not currently feasible for every GPCR or GPCR–ligand complex...
View article titled, Using the fragment molecular orbital method to investigate agonist–orexin-2 receptor interactions
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Articles

GPCR–styrene maleic acid lipid particles (GPCR–SMALPs): their nature and potential

Mark Wheatley, Jack Charlton, Mohammed Jamshad, Sarah J. Routledge, Sian Bailey, Penelope J. La-Borde, Maria T. Azam, Richard T. Logan, Roslyn M. Bill, Tim R. Dafforn, David R. Poyner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 619–623.
https://doi.org/10.1042/BST20150284
Published: 11 April 2016
...Mark Wheatley; Jack Charlton; Mohammed Jamshad; Sarah J. Routledge; Sian Bailey; Penelope J. La-Borde; Maria T. Azam; Richard T. Logan; Roslyn M. Bill; Tim R. Dafforn; David R. Poyner G-protein-coupled receptors (GPCRs) form the largest class of membrane proteins and are an important target...
View article titled, GPCR–styrene maleic acid lipid particles (GPCR–SMALPs): their nature and potential
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Articles

Evidence for the heterotetrameric structure of the adenosine A 2A –dopamine D 2 receptor complex

Verònica Casadó-Anguera, Jordi Bonaventura, Estefanía Moreno, Gemma Navarro, Antoni Cortés, Sergi Ferré, Vicent Casadó
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 595–600.
https://doi.org/10.1042/BST20150276
Published: 11 April 2016
...Verònica Casadó-Anguera; Jordi Bonaventura; Estefanía Moreno; Gemma Navarro; Antoni Cortés; Sergi Ferré; Vicent Casadó Heteromers of G-protein-coupled receptors (GPCRs) have emerged as potential novel targets for drug development. Accumulating evidence indicates that GPCRs can form homodimers...
View article titled, Evidence for the heterotetrameric structure of the adenosine A 2A –dopamine D 2 receptor complex
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Articles

Epac proteins: specific ligands and role in cardiac remodelling

Malik Bisserier, Jean-Paul Blondeau, Frank Lezoualc’h
Journal: Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 257–264.
https://doi.org/10.1042/BST20140033
Published: 20 March 2014
.... Consistent with this, a cAMP-responsive signalling complex that includes Epac1 and PDE4D3 has been identified in cardiac myocytes [ 28 ]. cAMP cardiac disease exchange protein directly activated by cAMP (Epac) G-protein-coupled receptor (GPCR) heart failure phosphodiesterase cAMP...
View article titled, Epac proteins: specific ligands and role in cardiac remodelling
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Articles

Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease

Fiore Cattaruzza, Daniel P. Poole, Nigel W. Bunnett
Journal: Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 137–143.
https://doi.org/10.1042/BST20120343
Published: 29 January 2013
...-arrestin-2 [ 33 ]. arrestin endosome G-protein-coupled receptor (GPCR) neuropeptide protease trafficking With almost 1000 members, the heptahelical GPCRs (G-protein-coupled receptors) comprise the largest family of cell-surface receptors. They allow cells to detect and respond...
View article titled, Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease
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Articles

G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms

Bice Chini, Marco Parenti, David R. Poyner, Mark Wheatley
Journal: Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 135–136.
https://doi.org/10.1042/BST20120344
Published: 29 January 2013
...-arrestin crystal structure G-protein-coupled receptor (GPCR) modelling pharmacology What of the future? Arising from the meeting, we think that it is possible to see a number of important areas for future research in GPCR biology. The crystal structures are wonderfully revealing, but provide...
View article titled, G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms
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Articles

Palmitoylation of serotonin receptors

Nataliya Gorinski, Evgeni Ponimaskin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 89–94.
https://doi.org/10.1042/BST20120235
Published: 29 January 2013
... be dynamically regulated, it is now widely accepted that repeated cycles of palmitoylation and depalmitoylation could have important functional consequences for signalling [ 1 , 2 ]. 1 To whom correspondence should be addressed (e-mail ponimaskin.evgeni@mh-hannover.de ). G-protein-coupled receptor...
View article titled, Palmitoylation of serotonin receptors
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Articles

Conserved activation pathways in G-protein-coupled receptors

Xavier Deupi, Jörg Standfuss, Gebhard Schertler
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (2): 383–388.
https://doi.org/10.1042/BST20120001
Published: 21 March 2012
... ). 6 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 adenosine receptor adrenergic receptor G-protein-coupled receptor (GPCR) metarhodopsin-II retinal rhodopsin GPCRs (G-protein-coupled receptors) are a family of seven-transmembrane helix proteins...
View article titled, Conserved activation pathways in G-protein-coupled receptors
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Articles

Insights into the activation mechanism of the visual receptor rhodopsin

Steven O. Smith
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (2): 389–393.
https://doi.org/10.1042/BST20110751
Published: 21 March 2012
... sensitive dim-light photoreceptor in vertebrates, as well as the common elements that it shares with the large class A GPCR family. However, despite progress, a number of questions remain unanswered about how these receptors are activated. G-protein-coupled receptor (GPCR) retinal chromophore rhodopsin...
View article titled, Insights into the activation mechanism of the visual receptor rhodopsin
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Articles

Crystallizing membrane proteins for structure–function studies using lipidic mesophases

Martin Caffrey
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (3): 725–732.
https://doi.org/10.1042/BST0390725
Published: 20 May 2011
... crystallization G-protein-coupled receptor (GPCR) lipidic cubic phase macromolecular crystallography membrane protein structure mesophase robot structure–function analysis The 13 January 2011 issue of the journal Nature includes three papers reporting on the structure and function of medically...
View article titled, Crystallizing membrane proteins for structure–function studies using lipidic mesophases
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Articles

Systems biochemistry approaches to vertebrate phototransduction: towards a molecular understanding of disease

Daniele Dell'Orco, Karl-Wilhelm Koch
Journal: Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1275–1280.
https://doi.org/10.1042/BST0381275
Published: 24 September 2010
... G-protein-coupled receptor (GPCR) kinetic modelling Leber congenital amaurosis phototransduction rod systems biology The primary events in vertebrate vision are the biochemical steps in the phototransduction cascade in rods and cones, the retinal photoreceptor cells. This signal...
View article titled, Systems biochemistry approaches to vertebrate phototransduction: towards a molecular understanding of disease
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Articles

Intestinal glucose sensing and regulation of intestinal glucose absorption

J. Dyer, K. Daly, K.S.H. Salmon, D.K. Arora, Z. Kokrashvili, R.F. Margolskee, S.P. Shirazi-Beechey
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1191–1194.
https://doi.org/10.1042/BST0351191
Published: 25 October 2007
... Journal compilation © 2007 Biochemical Society 2007 enteroendocrine cell G-protein-coupled receptor (GPCR) gut hormone intestinal glucose sensing sodium/glucose co-transporter 1 (SGLT1) taste receptor Glucose in the lumen of the intestine evokes various changes in gastrointestinal function...
View article titled, Intestinal glucose sensing and regulation of intestinal glucose absorption
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Articles

Solid-state NMR spectroscopy as a tool for drug design: from membrane-embedded targets to amyloid fibrils

D.A. Middleton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 985–990.
https://doi.org/10.1042/BST0350985
Published: 25 October 2007
... 45 9906 9918 amyloid cross-polarization magic-angle spinning (CP-MAS) drug discovery G-protein-coupled receptor (GPCR) NMR solid-state NMR There are now numerous examples of how the search for new drug candidates has been hastened by structural information provided by X-ray...
View article titled, Solid-state NMR spectroscopy as a tool for drug design: from membrane-embedded targets to amyloid fibrils
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Articles

Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor

L.J. Miller, M. Dong, K.G. Harikumar, F. Gao
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 709–712.
https://doi.org/10.1042/BST0350709
Published: 20 July 2007
... Society 2007 G-protein-coupled receptor (GPCR) ligand binding mutagenesis photoaffinity labelling receptor activation secretin receptor Fluorescence techniques can provide complementary insights into the environment of indicators that can be situated at distinct sites throughout...
View article titled, Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor
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Articles

Monitoring interactions between G-protein-coupled receptors and β-arrestins

K.D.G. Pfleger, M.B. Dalrymple, J.R. Dromey, K.A. Eidne
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 764–766.
https://doi.org/10.1042/BST0350764
Published: 20 July 2007
.... Dalrymple M.B. Lim E.M.L. Thomas W.G. Eidne K.A. Cell. Signalling 2006 18 1664 1670 β-arrestin bioluminescence resonance energy transfer (BRET) clathrin G-protein-coupled receptor (GPCR) live-cell imaging protein–protein interaction There are clearly important...
View article titled, Monitoring interactions between G-protein-coupled receptors and β-arrestins
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Articles

Molecular mechanisms involved in vasoactive intestinal peptide receptor activation and regulation: current knowledge, similarities to and differences from the A family of G-protein-coupled receptors

I. Langer, P. Robberecht
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 724–728.
https://doi.org/10.1042/BST0350724
Published: 20 July 2007
... (IC2) [ 16 ], VPAC1 (Glu 394 located in C-terminus) [ 12 ] and CGRP1 (calcitonin gene-related peptide 1) receptors (Arg 151 located in IC1) [ 17 ]. dimerization G-protein-coupled receptor (GPCR) internalization phosphorylation signalling vasoactive intestinal peptide/pituitary adenylate...
View article titled, Molecular mechanisms involved in vasoactive intestinal peptide receptor activation and regulation: current knowledge, similarities to and differences from the A family of G-protein-coupled receptors
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Articles

Computational studies of Family A and Family B GPCRs

S. Vohra, S.V. Chintapalli, C.J.R. Illingworth, P.J. Reeves, P.M. Mullineaux, H.S.X. Clark, M.K. Dean, G.J.G. Upton, C.A. Reynolds
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 749–754.
https://doi.org/10.1042/BST0350749
Published: 20 July 2007
... 1 To whom correspondence should be addressed (email C.A.Reynolds@essex.ac.uk ). 4 5 2007 cold-spot alignment evolutionary trace G-protein-coupled receptor (GPCR) GCR1 Molecular Dynamics simulations receptor dimerization Family B G-protein coupled receptor (GPCRs...
View article titled, Computational studies of Family A and Family B GPCRs
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Includes: Supplementary data
Articles

Family Resemblances? Ligand Binding and Activation of Family A and B G-Protein-Coupled Receptors

D.R. Poyner, M. Wheatley
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 707–708.
https://doi.org/10.1042/BST0350707
Published: 20 July 2007
... articles. 11 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 drug design G-protein-coupled receptor (GPCR) ligand binding molecular modelling receptor activation This following collection of articles are based on talks given at the Biochemical Society...
View article titled, Family Resemblances? Ligand Binding and Activation of Family A and B G-Protein-Coupled Receptors
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Articles

Phenotypic classification of mutants: a tool for understanding ligand binding and activation of muscarinic acetylcholine receptors

E.C. Hulme, M.S. Bee, J.A. Goodwin
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 742–745.
https://doi.org/10.1042/BST0350742
Published: 20 July 2007
.... 1 To whom correspondence should be addressed (email ehulme@nimr.mrc.ac.uk ). 23 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 acetylcholine alanine-scanning mutagenesis G-protein-coupled receptor (GPCR) muscarinic acetylcholine receptor (mAChR...
View article titled, Phenotypic classification of mutants: a tool for understanding ligand binding and activation of muscarinic acetylcholine receptors
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Articles

Unravelling the mechanisms underpinning chemokine receptor activation and blockade by small molecules: a fine line between agonism and antagonism?

E. Wise, J.E. Pease
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 755–759.
https://doi.org/10.1042/BST0350755
Published: 20 July 2007
... chemokine receptor G-protein-coupled receptor (GPCR) signalling Chemokines are a family of predominantly basic low-molecular-mass proteins numbering over 40 in humans [ 1 ]. The term chemokine has its roots in the abridging of the earlier term ‘chemotactic cytokine’ and describes their ability...
View article titled, Unravelling the mechanisms underpinning chemokine receptor activation and blockade by small molecules: a fine line between agonism and antagonism?
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Articles

Peptide binding at the GLP-1 receptor

R. Mann, N. Nasr, D. Hadden, J. Sinfield, F. Abidi, S. Al-Sabah, R. López de Maturana, J. Treece-Birch, A. Willshaw, D. Donnelly
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 713–716.
https://doi.org/10.1042/BST0350713
Published: 20 July 2007
...) glucagon-like peptide receptor 1 (GLP1-R) G-protein-coupled receptor (GPCR) peptide binding Type 2 diabetes In order to better understand how GLP-1 [glucagon-like peptide-1-(7–36)-amide] and its analogues bind and activate the GLP-1R (GLP-1 receptor), our group have spent several years...
View article titled, Peptide binding at the GLP-1 receptor
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Articles

Mechanisms underlying agonist efficacy

P.G. Strange
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 733–736.
https://doi.org/10.1042/BST0350733
Published: 20 July 2007
... efficacy D 2 dopamine receptor G-protein-coupled receptor (GPCR) G-protein cycle guanosine 5′-[γ-[ 35 S]thio]triphosphate-binding assay ([ 35 S]GTP[S]-binding assay) kinetics Nevertheless, it is important to ask whether the relative efficacy values determined using this assay reflect relative...
View article titled, Mechanisms underlying agonist efficacy
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Articles

Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors

M. Wheatley, J. Simms, S.R. Hawtin, V.J. Wesley, D. Wootten, M. Conner, Z. Lawson, A.C. Conner, A. Baker, Y. Cashmore, R. Kendrick, R.A. Parslow
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 717–720.
https://doi.org/10.1042/BST0350717
Published: 20 July 2007
... of Life Sciences, University of Wales, Swansea SA2 8PP, U.K. 27 4 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 agonist G-protein-coupled receptor (GPCR) peptide hormone receptor activation vasopressin GPCRs (G-protein-coupled receptors...
View article titled, Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors
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Articles

Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges

B. Chini, M. Manning
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 737–741.
https://doi.org/10.1042/BST0350737
Published: 20 July 2007
... 2007 agonist selectivity bivalent ligand G-protein-coupled receptor (GPCR) oxytocin therapeutic agent vasopressin OT (oxytocin) and AVP (vasopressin) receptors belong to the superfamily of GPCRs (G-protein coupled receptors), which are integral membrane proteins characterized...
View article titled, Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges
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Articles

G-protein-coupled receptor signalling through protein networks

A.D. Strosberg, C. Nahmias
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 23–27.
https://doi.org/10.1042/BST0350023
Published: 22 January 2007
... © 2007 The Biochemical Society 2007 angiotensin receptor β-adrenoceptor G-protein G-protein-coupled receptor (GPCR) melatonin receptor protein network The first group of GPCRs (G-protein-coupled receptors) to be well characterized were the β-adrenoceptors, of which there are three...
View article titled, G-protein-coupled receptor signalling through protein networks
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Articles

Cannabinoids and PPARα signalling

Y. Sun, S.P.H. Alexander, D.A. Kendall, A.J. Bennett
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1095–1097.
https://doi.org/10.1042/BST0341095
Published: 25 October 2006
... for neuroprotective treatment. 1 To whom correspondence should be addressed (email stxys3@nottingham.ac.uk ). 20 7 2006 © 2006 The Biochemical Society 2006 cannabinoid receptor (CB receptor) central nervous system (CNS) G-protein-coupled receptor (GPCR) middle cerebral artery occlusion...
View article titled, Cannabinoids and PPARα signalling
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Articles

Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs

H. Potzinger, E. Geretti, B. Brandner, V. Wabitsch, A.-M. Piccinini, A. Rek, A.J. Kungl
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 435–437.
https://doi.org/10.1042/BST0340435
Published: 22 May 2006
... Society 2006 anti-inflammatory drug chemokine mutant glycomics glycosaminoglycan G-protein-coupled receptor (GPCR) protein engineering Chemokines induce cell migration and activation by binding to specific cell surface, seven-transmembrane-spanning GPCRs (G-protein-coupled receptors...
View article titled, Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs
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Articles

Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells

S. Spiegel, S. Milstien
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1362–1365.
https://doi.org/10.1042/BST0331362
Published: 26 October 2005
... provide new and useful targets for preventive or therapeutic measures. 1 To whom correspondence should be addressed (email sspiegel@vcu.edu ). 23 6 2005 © 2005 The Biochemical Society 2005 acylglycerol kinase epidermal growth factor (EGF) G-protein-coupled receptor (GPCR...
View article titled, Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells
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Articles

Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae

P.A. Insel, B.P. Head, H.H. Patel, D.M. Roth, R.A. Bundey, J.S. Swaney
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1131–1134.
https://doi.org/10.1042/BST0331131
Published: 26 October 2005
...P.A. Insel; B.P. Head; H.H. Patel; D.M. Roth; R.A. Bundey; J.S. Swaney G-protein-coupled receptors (GPCRs) and post-GPCR signalling components are expressed at low overall abundance in plasma membranes, yet they evoke rapid, high-fidelity responses. Considerable evidence suggests that GPCR...
View article titled, Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae
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Articles

Molecular mechanisms of GABA B receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator

V. Binet, C. Goudet, C. Brajon, L. Le Corre, F. Acher, J.-P. Pin, L. Prézeau
Journal: Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 871–872.
https://doi.org/10.1042/BST0320871
Published: 26 October 2004
... (GABA B ) receptor G-protein-coupled receptor (GPCR) heptahelical domain The human body is composed of billions of cells. Since these cells are linked and communicate in very well-organized systems, they constitute organisms. The nervous system is by far the most complex organ of the body...
View article titled, Molecular mechanisms of GABA B receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator
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Articles

The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices

Z. Lawson, M. Wheatley
Journal: Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1048–1050.
https://doi.org/10.1042/BST0321048
Published: 26 October 2004
... 433 63 71 17 Hoffmann C. Moro S. Nicholas R.A. Harden T.K. Jacobson K.A. J. Biol. Chem. 1999 274 14639 14647 18 Ballesteros J.A. Weinstein H. Methods Neurosci. 1995 25 366 428 agonist binding G-protein-coupled receptor (GPCR...
View article titled, The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices
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Articles

Kinetics of G-protein-coupled receptor signalling and desensitization

C. Krasel, J.-P. Vilardaga, M. Bünemann, M.J. Lohse
Journal: Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1029–1031.
https://doi.org/10.1042/BST0321029
Published: 26 October 2004
... it is possible that GRK phosphorylation of GPCRs depends on an additional conformational change in the receptor, which is not required for either G-protein activation or arrestin binding. © 2004 The Biochemical Society 2004 arrestin fluorescence resonance energy transfer (FRET) G-protein-coupled...
View article titled, Kinetics of G-protein-coupled receptor signalling and desensitization
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Articles

Evidence to support a spectrum of active states for the glucagon receptor

N. Strudwick, N. Bhogal, N.A. Evans, F.E. Blaney, J.B.C. Findlay
Journal: Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1037–1039.
https://doi.org/10.1042/BST0321037
Published: 26 October 2004
... cAMP regulatory element (CRE)-luciferase glucagon G-protein-coupled receptor (GPCR) mutagenesis receptor activation ternary complex The extended ternary complex model for GPCR (G-protein-coupled receptor) activation suggests that they interchange between inactive (R) and active (R*) states...
View article titled, Evidence to support a spectrum of active states for the glucagon receptor
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Articles

Phosphoinositide 3-kinase γ: kinase-dependent and -independent activities in cardiovascular function and disease

G. Alloatti, G. Montrucchio, G. Lembo, E. Hirsch
Journal: Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (2): 383–386.
https://doi.org/10.1042/bst0320383
Published: 01 April 2004
..., these data suggested expression of PI3K not only in blood vessels but also in cardiac muscle. Evidence supporting this hypothesis included the finding Key words: -adrenergic receptor, contractility, G-protein-coupled receptor (GPCR), heart disease, hypertrophy, phosphoinositide 3-kinase (PI3K...
View article titled, Phosphoinositide 3-kinase γ: kinase-dependent and -independent activities in cardiovascular function and disease
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Articles

EGFR signal transactivation in cancer cells

O.M. Fischer, S. Hart, A. Gschwind, A. Ullrich
Journal: Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1203–1208.
https://doi.org/10.1042/bst0311203
Published: 01 December 2003
... (ADAM) cancer cross-talk epidermal growth factor receptor (EGFR) G-protein-coupled receptor (GPCR) transactivation Abbreviations used: ADAM, a d isintegrin a nd m etalloprotease; ET-1, endothelin-1; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ERK...
View article titled, EGFR signal transactivation in cancer cells
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Articles

Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

S. Spiegel, S. Milstien
Journal: Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1216–1219.
https://doi.org/10.1042/bst0311216
Published: 01 December 2003
... ). 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 4 July 2003 © 2003 Biochemical Society 2003 cell growth and survival G-protein-coupled receptor (GPCR) sphingosine kinase sphingosine 1-phosphate (S1P) sphingosine 1-phosphate...
View article titled, Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways
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