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Keywords: G-protein-coupled receptor (GPCR)
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Articles
Biochem Soc Trans (2016) 44 (2): 619–623.
Published: 11 April 2016
...Mark Wheatley; Jack Charlton; Mohammed Jamshad; Sarah J. Routledge; Sian Bailey; Penelope J. La-Borde; Maria T. Azam; Richard T. Logan; Roslyn M. Bill; Tim R. Dafforn; David R. Poyner G-protein-coupled receptors (GPCRs) form the largest class of membrane proteins and are an important target for...
Articles
Biochem Soc Trans (2016) 44 (2): 595–600.
Published: 11 April 2016
...Verònica Casadó-Anguera; Jordi Bonaventura; Estefanía Moreno; Gemma Navarro; Antoni Cortés; Sergi Ferré; Vicent Casadó Heteromers of G-protein-coupled receptors (GPCRs) have emerged as potential novel targets for drug development. Accumulating evidence indicates that GPCRs can form homodimers and...
Articles
Biochem Soc Trans (2016) 44 (2): 574–581.
Published: 11 April 2016
...-based drug discovery (SBDD) process. Clearly, to begin SBDD, a structure is needed, and although there has been fantastic progress in solving G-protein-coupled receptor (GPCR) crystal structures, the process remains quite slow and is not currently feasible for every GPCR or GPCR–ligand complex. This...
Articles
Biochem Soc Trans (2014) 42 (2): 257–264.
Published: 20 March 2014
...-coupled receptor (GPCR) heart failure phosphodiesterase cAMP is an ubiquitous second messenger that plays a critical role in a multitude of biological functions [ 1 ]. It is one of the most important second messengers in the heart, regulating many physiological processes, such as cardiac...
Articles
Biochem Soc Trans (2013) 41 (1): 137–143.
Published: 29 January 2013
... targeting of cell-surface signalling. 1 To whom correspondence should be addressed (email nigel.bunnett@monash.edu ). 20 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 arrestin endosome G-protein-coupled receptor (GPCR) neuropeptide protease...
Articles
Biochem Soc Trans (2013) 41 (1): 89–94.
Published: 29 January 2013
...-hydroxytryptamine) receptors and its role in the regulation of receptor functions. 1 To whom correspondence should be addressed (e-mail ponimaskin.evgeni@mh-hannover.de ). 11 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 G-protein-coupled receptor (GPCR...
Articles
Biochem Soc Trans (2013) 41 (1): 135–136.
Published: 29 January 2013
... β-arrestin crystal structure G-protein-coupled receptor (GPCR) modelling pharmacology The Biochemical Society/Monash University Focused Meeting ‘G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms’ held in Prato in September 2012 has proved particularly timely...
Articles
Biochem Soc Trans (2012) 40 (2): 389–393.
Published: 21 March 2012
... © The Authors Journal compilation © 2012 Biochemical Society 2012 G-protein-coupled receptor (GPCR) retinal chromophore rhodopsin solid-state NMR transmembrane helix vision Rhodopsin is the visual pigment responsible for dim-light photoreception in vertebrates [ 1 – 3 ]. The...
Articles
Biochem Soc Trans (2012) 40 (2): 383–388.
Published: 21 March 2012
... gebhard.schertler@psi.ch ). 6 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 adenosine receptor adrenergic receptor G-protein-coupled receptor (GPCR) metarhodopsin-II retinal rhodopsin GPCRs (G-protein-coupled receptors) are a family of seven-transmembrane...
Articles
Biochem Soc Trans (2011) 39 (3): 725–732.
Published: 20 May 2011
... crystallization G-protein-coupled receptor (GPCR) lipidic cubic phase macromolecular crystallography membrane protein structure mesophase robot structure–function analysis The 13 January 2011 issue of the journal Nature includes three papers reporting on the structure and function of medically...
Articles
Biochem Soc Trans (2010) 38 (5): 1275–1280.
Published: 24 September 2010
... modelling G-protein-coupled receptor (GPCR) kinetic modelling Leber congenital amaurosis phototransduction rod systems biology The primary events in vertebrate vision are the biochemical steps in the phototransduction cascade in rods and cones, the retinal photoreceptor cells. This signal...
Articles
Biochem Soc Trans (2007) 35 (5): 1191–1194.
Published: 25 October 2007
... Journal compilation © 2007 Biochemical Society 2007 enteroendocrine cell G-protein-coupled receptor (GPCR) gut hormone intestinal glucose sensing sodium/glucose co-transporter 1 (SGLT1) taste receptor Glucose in the lumen of the intestine evokes various changes in gastrointestinal function...
Articles
Biochem Soc Trans (2007) 35 (5): 985–990.
Published: 25 October 2007
... © 2007 Biochemical Society 2007 amyloid cross-polarization magic-angle spinning (CP-MAS) drug discovery G-protein-coupled receptor (GPCR) NMR solid-state NMR There are now numerous examples of how the search for new drug candidates has been hastened by structural information provided...
Articles
Biochem Soc Trans (2007) 35 (4): 709–712.
Published: 20 July 2007
... Biochemical Society 2007 G-protein-coupled receptor (GPCR) ligand binding mutagenesis photoaffinity labelling receptor activation secretin receptor The superfamily of guanine nucleotide-binding protein (G-protein)-coupled receptors represents the largest group of cell membrane receptors and...
Articles
Biochem Soc Trans (2007) 35 (4): 764–766.
Published: 20 July 2007
... correspondence should be addressed (email kpfleger@waimr.uwa.edu.au ). 23 4 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 β-arrestin bioluminescence resonance energy transfer (BRET) clathrin G-protein-coupled receptor (GPCR) live-cell imaging protein–protein...
Articles
Biochem Soc Trans (2007) 35 (4): 724–728.
Published: 20 July 2007
...@ulb.ac.be ). 30 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 dimerization G-protein-coupled receptor (GPCR) internalization phosphorylation signalling vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor (VPAC...
Articles
Biochem Soc Trans (2007) 35 (4): 749–754.
Published: 20 July 2007
...@essex.ac.uk ). 4 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cold-spot alignment evolutionary trace G-protein-coupled receptor (GPCR) GCR1 Molecular Dynamics simulations receptor dimerization Family B G-protein coupled receptor (GPCRs), although...
Includes: Supplementary data
Articles
Biochem Soc Trans (2007) 35 (4): 755–759.
Published: 20 July 2007
... modulator antagonist chemokine receptor G-protein-coupled receptor (GPCR) signalling Chemokines are a family of predominantly basic low-molecular-mass proteins numbering over 40 in humans [ 1 ]. The term chemokine has its roots in the abridging of the earlier term ‘chemotactic cytokine’ and...
Articles
Biochem Soc Trans (2007) 35 (4): 713–716.
Published: 20 July 2007
... Authors Journal compilation © 2007 Biochemical Society 2007 exendin-4 (EX-4) glucagon-like peptide receptor 1 (GLP1-R) G-protein-coupled receptor (GPCR) peptide binding Type 2 diabetes In order to better understand how GLP-1 [glucagon-like peptide-1-(7–36)-amide] and its analogues bind...
Articles
Biochem Soc Trans (2007) 35 (4): 733–736.
Published: 20 July 2007
... agonist efficacy D 2 dopamine receptor G-protein-coupled receptor (GPCR) G-protein cycle guanosine 5′-[γ-[ 35 S]thio]triphosphate-binding assay ([ 35 S]GTP[S]-binding assay) kinetics The actions of drugs at receptors depend on two events: the binding of the drug to the receptor and the...
Articles
Biochem Soc Trans (2007) 35 (4): 717–720.
Published: 20 July 2007
... Authors Journal compilation © 2007 Biochemical Society 2007 agonist G-protein-coupled receptor (GPCR) peptide hormone receptor activation vasopressin GPCRs (G-protein-coupled receptors) are a large family of structurally related proteins which mediate their effects by coupling to G...
Articles
Biochem Soc Trans (2007) 35 (4): 737–741.
Published: 20 July 2007
... Biochemical Society 2007 agonist selectivity bivalent ligand G-protein-coupled receptor (GPCR) oxytocin therapeutic agent vasopressin OT (oxytocin) and AVP (vasopressin) receptors belong to the superfamily of GPCRs (G-protein coupled receptors), which are integral membrane proteins...
Articles
Biochem Soc Trans (2007) 35 (4): 707–708.
Published: 20 July 2007
... articles. 1 To whom correspondence should be addressed (email D.R.Poyner@aston.ac.uk ). 11 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 drug design G-protein-coupled receptor (GPCR) ligand binding molecular modelling receptor activation This...
Articles
Biochem Soc Trans (2007) 35 (4): 742–745.
Published: 20 July 2007
.... 1 To whom correspondence should be addressed (email ehulme@nimr.mrc.ac.uk ). 23 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 acetylcholine alanine-scanning mutagenesis G-protein-coupled receptor (GPCR) muscarinic acetylcholine receptor (mAChR...
Articles
Biochem Soc Trans (2007) 35 (1): 23–27.
Published: 22 January 2007
... © 2007 The Biochemical Society 2007 angiotensin receptor β-adrenoceptor G-protein G-protein-coupled receptor (GPCR) melatonin receptor protein network The first group of GPCRs (G-protein-coupled receptors) to be well characterized were the β-adrenoceptors, of which there are three...
Articles
Biochem Soc Trans (2006) 34 (6): 1095–1097.
Published: 25 October 2006
... for neuroprotective treatment. 1 To whom correspondence should be addressed (email stxys3@nottingham.ac.uk ). 20 7 2006 © 2006 The Biochemical Society 2006 cannabinoid receptor (CB receptor) central nervous system (CNS) G-protein-coupled receptor (GPCR) middle cerebral...
Articles
Biochem Soc Trans (2006) 34 (3): 435–437.
Published: 22 May 2006
... Society 2006 anti-inflammatory drug chemokine mutant glycomics glycosaminoglycan G-protein-coupled receptor (GPCR) protein engineering Chemokines induce cell migration and activation by binding to specific cell surface, seven-transmembrane-spanning GPCRs (G-protein-coupled receptors) on...
Articles
Biochem Soc Trans (2005) 33 (5): 1131–1134.
Published: 26 October 2005
...P.A. Insel; B.P. Head; H.H. Patel; D.M. Roth; R.A. Bundey; J.S. Swaney G-protein-coupled receptors (GPCRs) and post-GPCR signalling components are expressed at low overall abundance in plasma membranes, yet they evoke rapid, high-fidelity responses. Considerable evidence suggests that GPCR...
Articles
Biochem Soc Trans (2005) 33 (6): 1362–1365.
Published: 26 October 2005
... provide new and useful targets for preventive or therapeutic measures. 1 To whom correspondence should be addressed (email sspiegel@vcu.edu ). 23 6 2005 © 2005 The Biochemical Society 2005 acylglycerol kinase epidermal growth factor (EGF) G-protein-coupled receptor (GPCR...
Articles
Biochem Soc Trans (2004) 32 (5): 871–872.
Published: 26 October 2004
...-aminobutyric acid-B (GABA B ) receptor G-protein-coupled receptor (GPCR) heptahelical domain The human body is composed of billions of cells. Since these cells are linked and communicate in very well-organized systems, they constitute organisms. The nervous system is by far the most complex organ of...
Articles
Biochem Soc Trans (2004) 32 (6): 1048–1050.
Published: 26 October 2004
... agonist binding G-protein-coupled receptor (GPCR) peptide hormone receptor activation GPCRs (G-protein-coupled receptors) can be divided into three major groups on the basis of sequence homology, namely the rhodopsin/β-AR (β-adrenergic receptor) family (Family A), the secretin receptor family...
Articles
Biochem Soc Trans (2004) 32 (6): 1029–1031.
Published: 26 October 2004
...@toxi.uni-wuerzburg.de ). 18 6 2004 © 2004 The Biochemical Society 2004 arrestin fluorescence resonance energy transfer (FRET) G-protein-coupled receptor (GPCR) heterotrimeric G-protein kinetics GPCRs constitute one of the largest protein families in the human genome, with...
Articles
Biochem Soc Trans (2004) 32 (6): 1037–1039.
Published: 26 October 2004
... Society 2004 cAMP regulatory element (CRE)-luciferase glucagon G-protein-coupled receptor (GPCR) mutagenesis receptor activation ternary complex The extended ternary complex model for GPCR (G-protein-coupled receptor) activation suggests that they interchange between inactive (R) and...
Articles
Biochem Soc Trans (2004) 32 (2): 383–386.
Published: 01 April 2004
... cardiovascular physiology, these data suggested expression of PI3K not only in blood vessels but also in cardiac muscle. Evidence supporting this hypothesis included the finding Key words: -adrenergic receptor, contractility, G-protein-coupled receptor (GPCR), heart disease, hypertrophy, phosphoinositide 3...
Articles
Biochem Soc Trans (2003) 31 (6): 1203–1208.
Published: 01 December 2003
... disintegrin and metalloprotease (ADAM) cancer cross-talk epidermal growth factor receptor (EGFR) G-protein-coupled receptor (GPCR) transactivation Abbreviations used: ADAM, a d isintegrin a nd m etalloprotease; ET-1, endothelin-1; EGF, epidermal growth factor; EGFR, epidermal growth factor...
Articles
Biochem Soc Trans (2003) 31 (6): 1216–1219.
Published: 01 December 2003
... ). 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 4 July 2003 © 2003 Biochemical Society 2003 cell growth and survival G-protein-coupled receptor (GPCR) sphingosine kinase sphingosine 1-phosphate (S1P) sphingosine 1-phosphate...