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Keywords: G-protein-coupled receptor (GPCR)
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Articles
Alexander Heifetz, Matteo Aldeghi, Ewa I. Chudyk, Dmitri G. Fedorov, Mike J. Bodkin, Philip C. Biggin
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 574–581.
Published: 11 April 2016
...-based drug discovery (SBDD) process. Clearly, to begin SBDD, a structure is needed, and although there has been fantastic progress in solving G-protein-coupled receptor (GPCR) crystal structures, the process remains quite slow and is not currently feasible for every GPCR or GPCR–ligand complex...
Articles
Mark Wheatley, Jack Charlton, Mohammed Jamshad, Sarah J. Routledge, Sian Bailey, Penelope J. La-Borde, Maria T. Azam, Richard T. Logan, Roslyn M. Bill, Tim R. Dafforn, David R. Poyner
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 619–623.
Published: 11 April 2016
...Mark Wheatley; Jack Charlton; Mohammed Jamshad; Sarah J. Routledge; Sian Bailey; Penelope J. La-Borde; Maria T. Azam; Richard T. Logan; Roslyn M. Bill; Tim R. Dafforn; David R. Poyner G-protein-coupled receptors (GPCRs) form the largest class of membrane proteins and are an important target...
Articles
Verònica Casadó-Anguera, Jordi Bonaventura, Estefanía Moreno, Gemma Navarro, Antoni Cortés, Sergi Ferré, Vicent Casadó
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 595–600.
Published: 11 April 2016
...Verònica Casadó-Anguera; Jordi Bonaventura; Estefanía Moreno; Gemma Navarro; Antoni Cortés; Sergi Ferré; Vicent Casadó Heteromers of G-protein-coupled receptors (GPCRs) have emerged as potential novel targets for drug development. Accumulating evidence indicates that GPCRs can form homodimers...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 257–264.
Published: 20 March 2014
... specific cellular responses [ 5 ]. cAMP cardiac disease exchange protein directly activated by cAMP (Epac) G-protein-coupled receptor (GPCR) heart failure phosphodiesterase © The Authors Journal compilation © 2014 Biochemical Society 2014 20 1 2014 1 To whom...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 135–136.
Published: 29 January 2013
...-arrestin crystal structure G-protein-coupled receptor (GPCR) modelling pharmacology What of the future? Arising from the meeting, we think that it is possible to see a number of important areas for future research in GPCR biology. The crystal structures are wonderfully revealing, but provide...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 137–143.
Published: 29 January 2013
... targeting of cell-surface signalling. 1 To whom correspondence should be addressed (email nigel.bunnett@monash.edu ). 20 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 arrestin endosome G-protein-coupled receptor (GPCR) neuropeptide protease...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 89–94.
Published: 29 January 2013
... should be addressed (e-mail ponimaskin.evgeni@mh-hannover.de ). 11 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 G-protein-coupled receptor (GPCR) palmitoylation serotonin (5-hydroxytryptamine) signal transduction This study was supported...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (2): 383–388.
Published: 21 March 2012
... , red arrow). 1 To whom correspondence should be addressed (email gebhard.schertler@psi.ch ). 6 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 adenosine receptor adrenergic receptor G-protein-coupled receptor (GPCR) metarhodopsin-II retinal...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (2): 389–393.
Published: 21 March 2012
... © The Authors Journal compilation © 2012 Biochemical Society 2012 G-protein-coupled receptor (GPCR) retinal chromophore rhodopsin solid-state NMR transmembrane helix vision All visual pigments contain the 11- cis isomer of retinal as their photoreactive chromophore...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (3): 725–732.
Published: 20 May 2011
... crystallization G-protein-coupled receptor (GPCR) lipidic cubic phase macromolecular crystallography membrane protein structure mesophase robot structure–function analysis The 13 January 2011 issue of the journal Nature includes three papers reporting on the structure and function of medically...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1275–1280.
Published: 24 September 2010
... molecular mechanisms in the light adaptation phenomena, i.e. the characteristic non-linear behaviours of photoreceptors in response to changes in the stimuli as related to previous light/dark conditions. dynamic modelling G-protein-coupled receptor (GPCR) kinetic modelling Leber congenital amaurosis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1191–1194.
Published: 25 October 2007
... A. Garriga C. Mitjans M. Planas J.M. Am. J. Physiol. Gastroinstest. Liver Physiol. 2002 282 G559 G564 © The Authors Journal compilation © 2007 Biochemical Society 2007 enteroendocrine cell G-protein-coupled receptor (GPCR) gut hormone intestinal glucose sensing sodium...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 985–990.
Published: 25 October 2007
... 2007 Biochemical Society 2007 amyloid cross-polarization magic-angle spinning (CP-MAS) drug discovery G-protein-coupled receptor (GPCR) NMR solid-state NMR There are now numerous examples of how the search for new drug candidates has been hastened by structural information provided...
Articles
S. Vohra, S.V. Chintapalli, C.J.R. Illingworth, P.J. Reeves, P.M. Mullineaux, H.S.X. Clark, M.K. Dean, G.J.G. Upton, C.A. Reynolds
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 749–754.
Published: 20 July 2007
... root of the proportion of the most common residue multiplied by the number of different residue types. An in-house clustering algorithm was used. cold-spot alignment evolutionary trace G-protein-coupled receptor (GPCR) GCR1 Molecular Dynamics simulations receptor dimerization...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 755–759.
Published: 20 July 2007
...@imperial.ac.uk ) allosteric modulator antagonist chemokine receptor G-protein-coupled receptor (GPCR) signalling Chemokines are a family of predominantly basic low-molecular-mass proteins numbering over 40 in humans [ 1 ]. The term chemokine has its roots in the abridging of the earlier term...
Articles
R. Mann, N. Nasr, D. Hadden, J. Sinfield, F. Abidi, S. Al-Sabah, R. López de Maturana, J. Treece-Birch, A. Willshaw, D. Donnelly
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 713–716.
Published: 20 July 2007
... The Authors Journal compilation © 2007 Biochemical Society 2007 exendin-4 (EX-4) glucagon-like peptide receptor 1 (GLP1-R) G-protein-coupled receptor (GPCR) peptide binding Type 2 diabetes GLP-1 is a 30-amino-acid peptide hormone secreted into the bloodstream in response to the ingestion...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 733–736.
Published: 20 July 2007
....). 1 email P.G.Strange@rdg.ac.uk 29 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 agonist efficacy D 2 dopamine receptor G-protein-coupled receptor (GPCR) G-protein cycle guanosine 5′-[γ-[ 35 S]thio]triphosphate-binding assay ([ 35 S]GTP[S]-binding...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 707–708.
Published: 20 July 2007
... articles. drug design G-protein-coupled receptor (GPCR) ligand binding molecular modelling receptor activation This following collection of articles are based on talks given at the Biochemical Society Focused Meeting on “Family Resemblances? Ligand Binding and Activation of Family A and B G...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 742–745.
Published: 20 July 2007
.... 1 To whom correspondence should be addressed (email ehulme@nimr.mrc.ac.uk ). 23 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 acetylcholine alanine-scanning mutagenesis G-protein-coupled receptor (GPCR) muscarinic acetylcholine receptor (mAChR...
Articles
M. Wheatley, J. Simms, S.R. Hawtin, V.J. Wesley, D. Wootten, M. Conner, Z. Lawson, A.C. Conner, A. Baker, Y. Cashmore, R. Kendrick, R.A. Parslow
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 717–720.
Published: 20 July 2007
... GPCR G-protein-coupled receptor OT oxytocin OTR oxytocin receptor TM transmembrane helix V 1a R (etc.) V 1a vasopressin receptor (etc.) agonist G-protein-coupled receptor (GPCR) peptide hormone receptor activation vasopressin GPCRs (G-protein-coupled...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 737–741.
Published: 20 July 2007
... Society 2007 agonist selectivity bivalent ligand G-protein-coupled receptor (GPCR) oxytocin therapeutic agent vasopressin OT (oxytocin) and AVP (vasopressin) receptors belong to the superfamily of GPCRs (G-protein coupled receptors), which are integral membrane proteins characterized...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 709–712.
Published: 20 July 2007
... Society 2007 G-protein-coupled receptor (GPCR) ligand binding mutagenesis photoaffinity labelling receptor activation secretin receptor Fluorescence techniques can provide complementary insights into the environment of indicators that can be situated at distinct sites throughout...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 764–766.
Published: 20 July 2007
....). β-arrestin bioluminescence resonance energy transfer (BRET) clathrin G-protein-coupled receptor (GPCR) live-cell imaging protein–protein interaction GPCRs (G-protein-coupled receptors) interact with a range of proteins, either directly or indirectly, in order to function as agonist...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 724–728.
Published: 20 July 2007
.... 2006 148 1051 1059 30 3 2007 dimerization G-protein-coupled receptor (GPCR) internalization phosphorylation signalling vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor (VPAC) Upon ligand binding, which involves a hydrophobic core...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 23–27.
Published: 22 January 2007
... binding to the receptor. angiotensin receptor β-adrenoceptor G-protein G-protein-coupled receptor (GPCR) melatonin receptor protein network We also now know that many GPCRs form homo- or hetero-dimers before or upon ligand binding, signal transduction or receptor internalization...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1095–1097.
Published: 25 October 2006
... The Biochemical Society 2006 cannabinoid receptor (CB receptor) central nervous system (CNS) G-protein-coupled receptor (GPCR) middle cerebral artery occlusion neuroprotection peroxisome-proliferator-activated receptor (PPAR) THC (Δ 9 -tetrahydrocannabinol) is the main psychoactive ingredient...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 435–437.
Published: 22 May 2006
... Society 2006 anti-inflammatory drug chemokine mutant glycomics glycosaminoglycan G-protein-coupled receptor (GPCR) protein engineering Chemokines induce cell migration and activation by binding to specific cell surface, seven-transmembrane-spanning GPCRs (G-protein-coupled receptors...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1362–1365.
Published: 26 October 2005
... provide new and useful targets for preventive or therapeutic measures. 1 To whom correspondence should be addressed (email sspiegel@vcu.edu ). 23 6 2005 © 2005 The Biochemical Society 2005 acylglycerol kinase epidermal growth factor (EGF) G-protein-coupled receptor (GPCR...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1131–1134.
Published: 26 October 2005
...P.A. Insel; B.P. Head; H.H. Patel; D.M. Roth; R.A. Bundey; J.S. Swaney G-protein-coupled receptors (GPCRs) and post-GPCR signalling components are expressed at low overall abundance in plasma membranes, yet they evoke rapid, high-fidelity responses. Considerable evidence suggests that GPCR...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 871–872.
Published: 26 October 2004
... acid-B (GABA B ) receptor G-protein-coupled receptor (GPCR) heptahelical domain References 1 Owens D. Kriegstein A. Nat. Rev. 2002 3 715 725 2 Balerio G. Rubio M. Pharmacol. Res. 2002 46 281 286 3 Schuler V. Luscher C. Blanchet C...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1029–1031.
Published: 26 October 2004
...@toxi.uni-wuerzburg.de ). 18 6 2004 © 2004 The Biochemical Society 2004 arrestin fluorescence resonance energy transfer (FRET) G-protein-coupled receptor (GPCR) heterotrimeric G-protein kinetics GPCRs constitute one of the largest protein families in the human genome...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1037–1039.
Published: 26 October 2004
... activity was observed for either of these mutants after exposure to glucagon-NH 2 (results not shown). © 2004 The Biochemical Society 2004 cAMP regulatory element (CRE)-luciferase glucagon G-protein-coupled receptor (GPCR) mutagenesis receptor activation ternary complex The extended...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1048–1050.
Published: 26 October 2004
... thyrotropin receptor Financial support from the Wellcome Trust and BBSRC is gratefully acknowledged. 1 To whom correspondence should be addressed (email m.wheatley@bham.ac.uk ). 23 7 2004 © 2004 The Biochemical Society 2004 agonist binding G-protein-coupled receptor...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (2): 383–386.
Published: 01 April 2004
..., these data suggested expression of PI3K not only in blood vessels but also in cardiac muscle. Evidence supporting this hypothesis included the finding Key words: -adrenergic receptor, contractility, G-protein-coupled receptor (GPCR), heart disease, hypertrophy, phosphoinositide 3-kinase (PI3K...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1203–1208.
Published: 01 December 2003
... (ADAM) cancer cross-talk epidermal growth factor receptor (EGFR) G-protein-coupled receptor (GPCR) transactivation Abbreviations used: ADAM, a d isintegrin a nd m etalloprotease; ET-1, endothelin-1; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ERK...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1216–1219.
Published: 01 December 2003
... ). 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 4 July 2003 © 2003 Biochemical Society 2003 cell growth and survival G-protein-coupled receptor (GPCR) sphingosine kinase sphingosine 1-phosphate (S1P) sphingosine 1-phosphate...
