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Articles

Using the fragment molecular orbital method to investigate agonist–orexin-2 receptor interactions

Alexander Heifetz, Matteo Aldeghi, Ewa I. Chudyk, Dmitri G. Fedorov, Mike J. Bodkin, Philip C. Biggin

Biochem Soc Trans (2016) 44 (2): 574–581.

https://doi.org/10.1042/BST20150250

Published: 11 April 2016

...-based drug discovery (SBDD) process. Clearly, to begin SBDD, a structure is needed, and although there has been fantastic progress in solving G-protein-coupled receptor (GPCR) crystal structures, the process remains quite slow and is not currently feasible for every GPCR or GPCR–ligand complex...

View articletitled, Using the fragment molecular orbital method to investigate agonist–orexin-2 receptor interactions

Articles

GPCR–styrene maleic acid lipid particles (GPCR–SMALPs): their nature and potential

Mark Wheatley, Jack Charlton, Mohammed Jamshad, Sarah J. Routledge, Sian Bailey, Penelope J. La-Borde, Maria T. Azam, Richard T. Logan, Roslyn M. Bill, Tim R. Dafforn, David R. Poyner

Biochem Soc Trans (2016) 44 (2): 619–623.

https://doi.org/10.1042/BST20150284

Published: 11 April 2016

...Mark Wheatley; Jack Charlton; Mohammed Jamshad; Sarah J. Routledge; Sian Bailey; Penelope J. La-Borde; Maria T. Azam; Richard T. Logan; Roslyn M. Bill; Tim R. Dafforn; David R. Poyner G-protein-coupled receptors (GPCRs) form the largest class of membrane proteins and are an important target...

View articletitled, GPCR–styrene maleic acid lipid particles (GPCR–SMALPs): their nature and potential

Articles

Evidence for the heterotetrameric structure of the adenosine A 2A –dopamine D 2 receptor complex

Verònica Casadó-Anguera, Jordi Bonaventura, Estefanía Moreno, Gemma Navarro, Antoni Cortés, Sergi Ferré, Vicent Casadó

Biochem Soc Trans (2016) 44 (2): 595–600.

https://doi.org/10.1042/BST20150276

Published: 11 April 2016

...Verònica Casadó-Anguera; Jordi Bonaventura; Estefanía Moreno; Gemma Navarro; Antoni Cortés; Sergi Ferré; Vicent Casadó Heteromers of G-protein-coupled receptors (GPCRs) have emerged as potential novel targets for drug development. Accumulating evidence indicates that GPCRs can form homodimers...

View articletitled, Evidence for the heterotetrameric structure of the adenosine A 2A –dopamine D 2 receptor complex

Articles

Epac proteins: specific ligands and role in cardiac remodelling

Malik Bisserier, Jean-Paul Blondeau, Frank Lezoualc’h

Biochem Soc Trans (2014) 42 (2): 257–264.

https://doi.org/10.1042/BST20140033

Published: 20 March 2014

...-protein-coupled receptor (GPCR) heart failure phosphodiesterase cAMP is an ubiquitous second messenger that plays a critical role in a multitude of biological functions [ 1 ]. It is one of the most important second messengers in the heart, regulating many physiological processes, such as cardiac...

View articletitled, Epac proteins: specific ligands and role in cardiac remodelling

Articles

Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease

Fiore Cattaruzza, Daniel P. Poole, Nigel W. Bunnett

Biochem Soc Trans (2013) 41 (1): 137–143.

https://doi.org/10.1042/BST20120343

Published: 29 January 2013

... targeting of cell-surface signalling. 1 To whom correspondence should be addressed (email [email protected] ). 20 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 arrestin endosome G-protein-coupled receptor (GPCR) neuropeptide protease...

View articletitled, Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease

Articles

G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms

Bice Chini, Marco Parenti, David R. Poyner, Mark Wheatley

Biochem Soc Trans (2013) 41 (1): 135–136.

https://doi.org/10.1042/BST20120344

Published: 29 January 2013

...-arrestin crystal structure G-protein-coupled receptor (GPCR) modelling pharmacology What of the future? Arising from the meeting, we think that it is possible to see a number of important areas for future research in GPCR biology. The crystal structures are wonderfully revealing, but provide...

View articletitled, G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms

Articles

Palmitoylation of serotonin receptors

Nataliya Gorinski, Evgeni Ponimaskin

Biochem Soc Trans (2013) 41 (1): 89–94.

https://doi.org/10.1042/BST20120235

Published: 29 January 2013

...-hydroxytryptamine) receptors and its role in the regulation of receptor functions. 11 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 G-protein-coupled receptor (GPCR) palmitoylation serotonin (5-hydroxytryptamine) signal transduction Cellular as well...

View articletitled, Palmitoylation of serotonin receptors

Articles

Conserved activation pathways in G-protein-coupled receptors

Xavier Deupi, Jörg Standfuss, Gebhard Schertler

Biochem Soc Trans (2012) 40 (2): 383–388.

https://doi.org/10.1042/BST20120001

Published: 21 March 2012

... ). 6 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 adenosine receptor adrenergic receptor G-protein-coupled receptor (GPCR) metarhodopsin-II retinal rhodopsin GPCRs (G-protein-coupled receptors) are a family of seven-transmembrane helix proteins...

View articletitled, Conserved activation pathways in G-protein-coupled receptors

Articles

Insights into the activation mechanism of the visual receptor rhodopsin

Steven O. Smith

Biochem Soc Trans (2012) 40 (2): 389–393.

https://doi.org/10.1042/BST20110751

Published: 21 March 2012

... © The Authors Journal compilation © 2012 Biochemical Society 2012 G-protein-coupled receptor (GPCR) retinal chromophore rhodopsin solid-state NMR transmembrane helix vision Solid-state NMR spectroscopy has also provided several insights into the structure of Meta II [ 21 ]. Solid...

View articletitled, Insights into the activation mechanism of the visual receptor rhodopsin

Articles

Crystallizing membrane proteins for structure–function studies using lipidic mesophases

Martin Caffrey

Biochem Soc Trans (2011) 39 (3): 725–732.

https://doi.org/10.1042/BST0390725

Published: 20 May 2011

... crystallization G-protein-coupled receptor (GPCR) lipidic cubic phase macromolecular crystallography membrane protein structure mesophase robot structure–function analysis The 13 January 2011 issue of the journal Nature includes three papers reporting on the structure and function of medically...

View articletitled, Crystallizing membrane proteins for structure–function studies using lipidic mesophases

Articles

Systems biochemistry approaches to vertebrate phototransduction: towards a molecular understanding of disease

Daniele Dell'Orco, Karl-Wilhelm Koch

Biochem Soc Trans (2010) 38 (5): 1275–1280.

https://doi.org/10.1042/BST0381275

Published: 24 September 2010

... G-protein-coupled receptor (GPCR) kinetic modelling Leber congenital amaurosis phototransduction rod systems biology The primary events in vertebrate vision are the biochemical steps in the phototransduction cascade in rods and cones, the retinal photoreceptor cells. This signal...

View articletitled, Systems biochemistry approaches to vertebrate phototransduction: towards a molecular understanding of disease

Articles

Solid-state NMR spectroscopy as a tool for drug design: from membrane-embedded targets to amyloid fibrils

D.A. Middleton

Biochem Soc Trans (2007) 35 (5): 985–990.

https://doi.org/10.1042/BST0350985

Published: 25 October 2007

... 2007 Biochemical Society 2007 amyloid cross-polarization magic-angle spinning (CP-MAS) drug discovery G-protein-coupled receptor (GPCR) NMR solid-state NMR There are now numerous examples of how the search for new drug candidates has been hastened by structural information provided...

View articletitled, Solid-state NMR spectroscopy as a tool for drug design: from membrane-embedded targets to amyloid fibrils

Articles

Intestinal glucose sensing and regulation of intestinal glucose absorption

J. Dyer, K. Daly, K.S.H. Salmon, D.K. Arora, Z. Kokrashvili, R.F. Margolskee, S.P. Shirazi-Beechey

Biochem Soc Trans (2007) 35 (5): 1191–1194.

https://doi.org/10.1042/BST0351191

Published: 25 October 2007

... Journal compilation © 2007 Biochemical Society 2007 enteroendocrine cell G-protein-coupled receptor (GPCR) gut hormone intestinal glucose sensing sodium/glucose co-transporter 1 (SGLT1) taste receptor In recent years, there has been remarkable progress made towards understanding...

View articletitled, Intestinal glucose sensing and regulation of intestinal glucose absorption

Articles

Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor

L.J. Miller, M. Dong, K.G. Harikumar, F. Gao

Biochem Soc Trans (2007) 35 (4): 709–712.

https://doi.org/10.1042/BST0350709

Published: 20 July 2007

... Society 2007 G-protein-coupled receptor (GPCR) ligand binding mutagenesis photoaffinity labelling receptor activation secretin receptor Fluorescence techniques can provide complementary insights into the environment of indicators that can be situated at distinct sites throughout...

View articletitled, Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor

Articles

Monitoring interactions between G-protein-coupled receptors and β-arrestins

K.D.G. Pfleger, M.B. Dalrymple, J.R. Dromey, K.A. Eidne

Biochem Soc Trans (2007) 35 (4): 764–766.

https://doi.org/10.1042/BST0350764

Published: 20 July 2007

... correspondence should be addressed (email [email protected] ). 23 4 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 β-arrestin bioluminescence resonance energy transfer (BRET) clathrin G-protein-coupled receptor (GPCR) live-cell imaging protein–protein...

View articletitled, Monitoring interactions between G-protein-coupled receptors and β-arrestins

Articles

Molecular mechanisms involved in vasoactive intestinal peptide receptor activation and regulation: current knowledge, similarities to and differences from the A family of G-protein-coupled receptors

I. Langer, P. Robberecht

Biochem Soc Trans (2007) 35 (4): 724–728.

https://doi.org/10.1042/BST0350724

Published: 20 July 2007

.... Mol. Pharmacol. 2006 69 363 373 34 Langer I. Gaspard N. Robberecht P. Br. J. Pharmacol. 2006 148 1051 1059 dimerization G-protein-coupled receptor (GPCR) internalization phosphorylation signalling vasoactive intestinal peptide/pituitary adenylate cyclase...

View articletitled, Molecular mechanisms involved in vasoactive intestinal peptide receptor activation and regulation: current knowledge, similarities to and differences from the A family of G-protein-coupled receptors

Articles

Computational studies of Family A and Family B GPCRs

S. Vohra, S.V. Chintapalli, C.J.R. Illingworth, P.J. Reeves, P.M. Mullineaux, H.S.X. Clark, M.K. Dean, G.J.G. Upton, C.A. Reynolds

Biochem Soc Trans (2007) 35 (4): 749–754.

https://doi.org/10.1042/BST0350749

Published: 20 July 2007

... ].) cold-spot alignment evolutionary trace G-protein-coupled receptor (GPCR) GCR1 Molecular Dynamics simulations receptor dimerization Family B G-protein coupled receptor (GPCRs), although less-well studied than Family A GPCRs, are interesting because their protein fold (in the N-terminus...

View articletitled, Computational studies of Family A and Family B GPCRs

Includes: Supplementary data

Articles

Family Resemblances? Ligand Binding and Activation of Family A and B G-Protein-Coupled Receptors

D.R. Poyner, M. Wheatley

Biochem Soc Trans (2007) 35 (4): 707–708.

https://doi.org/10.1042/BST0350707

Published: 20 July 2007

... articles. 1 To whom correspondence should be addressed (email [email protected] ). 11 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 drug design G-protein-coupled receptor (GPCR) ligand binding molecular modelling receptor activation...

View articletitled, Family Resemblances? Ligand Binding and Activation of Family A and B G-Protein-Coupled Receptors

Articles

Phenotypic classification of mutants: a tool for understanding ligand binding and activation of muscarinic acetylcholine receptors

E.C. Hulme, M.S. Bee, J.A. Goodwin

Biochem Soc Trans (2007) 35 (4): 742–745.

https://doi.org/10.1042/BST0350742

Published: 20 July 2007

.... 1 To whom correspondence should be addressed (email [email protected] ). 23 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 acetylcholine alanine-scanning mutagenesis G-protein-coupled receptor (GPCR) muscarinic acetylcholine receptor (mAChR...

View articletitled, Phenotypic classification of mutants: a tool for understanding ligand binding and activation of muscarinic acetylcholine receptors

Articles

Unravelling the mechanisms underpinning chemokine receptor activation and blockade by small molecules: a fine line between agonism and antagonism?

E. Wise, J.E. Pease

Biochem Soc Trans (2007) 35 (4): 755–759.

https://doi.org/10.1042/BST0350755

Published: 20 July 2007

.... Acad. Sci. U.S.A. 1977 74 2256 1 To whom correspondence should be addressed (email [email protected] ) 2 4 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 allosteric modulator antagonist chemokine receptor G-protein-coupled receptor...

View articletitled, Unravelling the mechanisms underpinning chemokine receptor activation and blockade by small molecules: a fine line between agonism and antagonism?

Articles

Peptide binding at the GLP-1 receptor

R. Mann, N. Nasr, D. Hadden, J. Sinfield, F. Abidi, S. Al-Sabah, R. López de Maturana, J. Treece-Birch, A. Willshaw, D. Donnelly

Biochem Soc Trans (2007) 35 (4): 713–716.

https://doi.org/10.1042/BST0350713

Published: 20 July 2007

... receptor. In order to better understand these differences, we have studied the interaction between combinations of full-length or truncated ligands with full-length or truncated receptors. exendin-4 (EX-4) glucagon-like peptide receptor 1 (GLP1-R) G-protein-coupled receptor (GPCR) peptide binding...

View articletitled, Peptide binding at the GLP-1 receptor

Articles

Mechanisms underlying agonist efficacy

P.G. Strange

Biochem Soc Trans (2007) 35 (4): 733–736.

https://doi.org/10.1042/BST0350733

Published: 20 July 2007

... that the very low agonist efficacy expressed by these drugs is important for their actions, and so systems that can define this efficacy are required. © The Authors Journal compilation © 2007 Biochemical Society 2007 agonist efficacy D 2 dopamine receptor G-protein-coupled receptor (GPCR) G...

View articletitled, Mechanisms underlying agonist efficacy

Articles

Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors

M. Wheatley, J. Simms, S.R. Hawtin, V.J. Wesley, D. Wootten, M. Conner, Z. Lawson, A.C. Conner, A. Baker, Y. Cashmore, R. Kendrick, R.A. Parslow

Biochem Soc Trans (2007) 35 (4): 717–720.

https://doi.org/10.1042/BST0350717

Published: 20 July 2007

... compilation © 2007 Biochemical Society 2007 agonist G-protein-coupled receptor (GPCR) peptide hormone receptor activation vasopressin GPCRs (G-protein-coupled receptors) are a large family of structurally related proteins which mediate their effects by coupling to G-proteins. Several hundred...

View articletitled, Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors

Articles

Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges

B. Chini, M. Manning

Biochem Soc Trans (2007) 35 (4): 737–741.

https://doi.org/10.1042/BST0350737

Published: 20 July 2007

... ] 0.45 [ 58 ] 1.54 [ 58 ] 0.29 [ 58 ] dDAVP 23.3 [ 54 ] 62.4 [ 54 ] 5.8 [ 54 ] 0.3 [ 54 ] 100 [ 54 ] 9.3 [ 32 ] © The Authors Journal compilation © 2007 Biochemical Society 2007 agonist selectivity bivalent ligand G-protein-coupled receptor (GPCR) oxytocin therapeutic...

View articletitled, Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challenges

Articles

G-protein-coupled receptor signalling through protein networks

A.D. Strosberg, C. Nahmias

Biochem Soc Trans (2007) 35 (1): 23–27.

https://doi.org/10.1042/BST0350023

Published: 22 January 2007

... Structure of the GPCR bovine rhodopsin with retinal bound The structure is shown both perpendicular and parallel to the membrane in which the protein is embedded. angiotensin receptor β-adrenoceptor G-protein G-protein-coupled receptor (GPCR) melatonin receptor protein network After...

View articletitled, G-protein-coupled receptor signalling through protein networks

Articles

Cannabinoids and PPARα signalling

Y. Sun, S.P.H. Alexander, D.A. Kendall, A.J. Bennett

Biochem Soc Trans (2006) 34 (6): 1095–1097.

https://doi.org/10.1042/BST0341095

Published: 25 October 2006

... The Biochemical Society 2006 cannabinoid receptor (CB receptor) central nervous system (CNS) G-protein-coupled receptor (GPCR) middle cerebral artery occlusion neuroprotection peroxisome-proliferator-activated receptor (PPAR) THC (Δ 9 -tetrahydrocannabinol) is the main psychoactive ingredient...

View articletitled, Cannabinoids and PPARα signalling

Articles

Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs

H. Potzinger, E. Geretti, B. Brandner, V. Wabitsch, A.-M. Piccinini, A. Rek, A.J. Kungl

Biochem Soc Trans (2006) 34 (3): 435–437.

https://doi.org/10.1042/BST0340435

Published: 22 May 2006

... Society 2006 anti-inflammatory drug chemokine mutant glycomics glycosaminoglycan G-protein-coupled receptor (GPCR) protein engineering Chemokines induce cell migration and activation by binding to specific cell surface, seven-transmembrane-spanning GPCRs (G-protein-coupled receptors...

View articletitled, Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs

Articles

Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae

P.A. Insel, B.P. Head, H.H. Patel, D.M. Roth, R.A. Bundey, J.S. Swaney

Biochem Soc Trans (2005) 33 (5): 1131–1134.

https://doi.org/10.1042/BST0331131

Published: 26 October 2005

...P.A. Insel; B.P. Head; H.H. Patel; D.M. Roth; R.A. Bundey; J.S. Swaney G-protein-coupled receptors (GPCRs) and post-GPCR signalling components are expressed at low overall abundance in plasma membranes, yet they evoke rapid, high-fidelity responses. Considerable evidence suggests that GPCR...

View articletitled, Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae

Articles

Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells

S. Spiegel, S. Milstien

Biochem Soc Trans (2005) 33 (6): 1362–1365.

https://doi.org/10.1042/BST0331362

Published: 26 October 2005

[email protected] ). 23 6 2005 © 2005 The Biochemical Society 2005 acylglycerol kinase epidermal growth factor (EGF) G-protein-coupled receptor (GPCR) lysophosphatidic acid (LPA) phosphatidic acid (PA) prostate cancer For over 50 years, the primary form of therapy for advanced...

View articletitled, Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells

Articles

Molecular mechanisms of GABA B receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator

V. Binet, C. Goudet, C. Brajon, L. Le Corre, F. Acher, J.-P. Pin, L. Prézeau

Biochem Soc Trans (2004) 32 (5): 871–872.

https://doi.org/10.1042/BST0320871

Published: 26 October 2004

... of GABA B receptor. 1 To whom correspondence should be addressed (email [email protected] ). 6 7 2004 © 2004 The Biochemical Society 2004 activation mechanism allostery dimerization γ-aminobutyric acid-B (GABA B ) receptor G-protein-coupled receptor (GPCR...

View articletitled, Molecular mechanisms of GABA B receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator

Articles

The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices

Z. Lawson, M. Wheatley

Biochem Soc Trans (2004) 32 (6): 1048–1050.

https://doi.org/10.1042/BST0321048

Published: 26 October 2004

... and that ECLs fulfil important functional roles within the GPCR architecture. In the present study, we examine the functional significance of ECL3, focusing primarily on Family A receptors. agonist binding G-protein-coupled receptor (GPCR) peptide hormone receptor activation © 2004...

View articletitled, The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices

Articles

Kinetics of G-protein-coupled receptor signalling and desensitization

C. Krasel, J.-P. Vilardaga, M. Bünemann, M.J. Lohse

Biochem Soc Trans (2004) 32 (6): 1029–1031.

https://doi.org/10.1042/BST0321029

Published: 26 October 2004

... it is possible that GRK phosphorylation of GPCRs depends on an additional conformational change in the receptor, which is not required for either G-protein activation or arrestin binding. © 2004 The Biochemical Society 2004 arrestin fluorescence resonance energy transfer (FRET) G-protein-coupled...

View articletitled, Kinetics of G-protein-coupled receptor signalling and desensitization

Articles

Evidence to support a spectrum of active states for the glucagon receptor

N. Strudwick, N. Bhogal, N.A. Evans, F.E. Blaney, J.B.C. Findlay

Biochem Soc Trans (2004) 32 (6): 1037–1039.

https://doi.org/10.1042/BST0321037

Published: 26 October 2004

.... Kobilka B.K. J. Biol. Chem. 2001 276 24433 24436 cAMP regulatory element (CRE)-luciferase glucagon G-protein-coupled receptor (GPCR) mutagenesis receptor activation ternary complex The extended ternary complex model for GPCR (G-protein-coupled receptor) activation suggests...

View articletitled, Evidence to support a spectrum of active states for the glucagon receptor

Articles

Phosphoinositide 3-kinase γ: kinase-dependent and -independent activities in cardiovascular function and disease

G. Alloatti, G. Montrucchio, G. Lembo, E. Hirsch

Biochem Soc Trans (2004) 32 (2): 383–386.

https://doi.org/10.1042/bst0320383

Published: 01 April 2004

..., these data suggested expression of PI3K not only in blood vessels but also in cardiac muscle. Evidence supporting this hypothesis included the finding Key words: -adrenergic receptor, contractility, G-protein-coupled receptor (GPCR), heart disease, hypertrophy, phosphoinositide 3-kinase (PI3K...

View articletitled, Phosphoinositide 3-kinase γ: kinase-dependent and -independent activities in cardiovascular function and disease

Articles

EGFR signal transactivation in cancer cells

O.M. Fischer, S. Hart, A. Gschwind, A. Ullrich

Biochem Soc Trans (2003) 31 (6): 1203–1208.

https://doi.org/10.1042/bst0311203

Published: 01 December 2003

... receptor (EGFR) G-protein-coupled receptor (GPCR) transactivation Abbreviations used: ADAM, a d isintegrin a nd m etalloprotease; ET-1, endothelin-1; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ERK, extracellular-signal-regulated kinase; GPCR, G-protein-coupled...

View articletitled, EGFR signal transactivation in cancer cells

Articles

Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

S. Spiegel, S. Milstien

Biochem Soc Trans (2003) 31 (6): 1216–1219.

https://doi.org/10.1042/bst0311216

Published: 01 December 2003

... ). 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 4 July 2003 © 2003 Biochemical Society 2003 cell growth and survival G-protein-coupled receptor (GPCR) sphingosine kinase sphingosine 1-phosphate (S1P) sphingosine 1-phosphate...

View articletitled, Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

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