... transmembrane proteins such as G-protein-coupled receptors, channels, enzymes, and membrane-associated lipidated proteins are enriched in the ciliary membrane. The precise regulation of ciliary membrane content is essential for effective signal transduction and maintenance of tissue homeostasis. Surprisingly...

... as a key interaction mediator for chemokine binding. Y291 7.43 on the other hand was shown in CCR1 to be a key determinant of signaling bias which, along with specific chemokine-dependent phosphorylation ensembles at the G-protein coupled receptors (GPCR's) C-terminus, seems to play a pivotal role...

... microscopy crystallography G-protein-coupled receptors Human endocannabinoid signaling is primarily mediated by the class A G protein-coupled receptors (GPCRs) CB1 and CB2. Class A GPCRs consist of an extracellular N-terminal domain, seven transmembrane spanning alpha helices, three extracellular...

...Gizem Kayki-Mutlu; Walter J. Koch G protein-coupled receptors (GPCRs) are key modulators of cell signaling. Multiple GPCRs are present in the heart where they regulate cardiac homeostasis including processes such as myocyte contraction, heart rate and coronary blood flow. GPCRs are pharmacological...

...Maria Marti-Solano G protein-coupled receptor (GPCR) family members can sense an extraordinary variety of biomolecules to activate intracellular signalling cascades that modulate key aspects of cell physiology. Apart from their crucial role in maintaining cell homeostasis, these critical sensory...

...) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . G-protein-coupled receptors nociception pain sensory neurons TRPV1 Another point of interest...

...Javier García-Nafría; Christopher G. Tate G protein-coupled receptors (GPCRs) are the largest single family of cell surface receptors encoded by the human genome and they play pivotal roles in co-ordinating cellular systems throughout the human body, making them ideal drug targets. Structural...

... between the receptors and the specific biomolecules generates functional information about the heteromer that can be pharmacologically quantified. This review will discuss various applications of Receptor-HIT, including its use with different classes of receptors (e.g. G protein-coupled receptors (GPCRs...

...Matthew Rosa; Timothy Noel; Matthew Harris; Graham Ladds Adhesion G protein-coupled receptors (aGPCRs) form a sub-group within the GPCR superfamily. Their distinctive structure contains an abnormally large N-terminal, extracellular region with a GPCR autoproteolysis-inducing (GAIN) domain. In most...

... provide an optimal environment for many G protein-coupled receptors (GPCRs) and their effectors to efficiently transmit their signals to the rest of the cell. For this to occur, however, all necessary receptors and signal transducers must first accumulate at the ciliary membrane. Serotonin receptor 6...

.... Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural and functional characteristics of the family of CRH-like peptides and their receptors. 1 To whom correspondence should be addressed (e...

... receptors IC3 vasoactive intestinal peptide VPAC 1 /VPAC 2 chimaeric receptors [Ca 2+ ] i , intracellular calcium concentration EC3, third extracellular loop (etc.) IC3, third intracellular loop (etc.) GPCR, G-protein-coupled receptor TM3, third transmembrane helix (etc.) VIP, vasoactive...