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Keywords: GPCR mutant
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Biochem Soc Trans (2013) 41 (1): 166–171.
Published: 29 January 2013
... a number of different active conformations, each capable of promoting the coupling to a specific effector. Consistently, functional-selective ligands and biased agonists have been described to be able to induce and/or stabilize only a subset of specific active conformations. Furthermore, GPCR mutants...