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Keywords: HCN1
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Biochem Soc Trans (2021) 49 (6): 2573–2579.
Published: 23 November 2021
... will discuss the recent advancement in understanding the molecular mechanisms connecting the VSD with the CNBD in the tetrameric organization of HCN channels unveiled by the 3D structures of HCN1 and HCN4. Data show that the HCN domain transmits cAMP signal to the VSD by bridging the cytosolic to the membrane...