.... The discovery of the human immunodeficiency virus (HIV) virus as the causing agent of acquired immunodeficiency syndrome (AIDS) decades ago, led to a tremendous amount of research. Among the findings, it was discovered that some rare HIV + individuals, called HIV controllers (HICs), had the ability to control...

..., favoring MT depolymerization. The enzyme responsible for deacetylation of this residue is not known [ 1 ]. Diverse viruses enhance tubulin PTMs, inducing MT stabilization. Among them, one of the most studied is HIV-1, due to its clinical implications and pathological mechanisms [ 45–50...

... that aim to block enveloped virus spread. In this review, we summarize the current knowledge on the role of plasma membrane lipid–protein interactions on viral assembly and budding. Ebola virus HIV lipid–protein interaction Marburg virus virus assembly virus budding Lipid-enveloped viruses...

..., SAMHD1 also restricts the replication of several retroviruses, such as HIV-1, and some DNA viruses in dendritic and myeloid lineage cells and resting T-cells. SAMHD1 activity is regulated throughout the cell cycle, both at the level of protein expression and post-translationally, through phosphorylation...

...Mickaël M. Ménager Dendritic cells (DCs) have essential roles in early detection of pathogens and activation of both innate and adaptive immune responses. Whereas human DCs are resistant to productive HIV-1 replication, they have a unique ability to take up virus and transmit it efficiently to T...

...Laura Hidalgo; Chad M. Swanson Human immunodeficiency virus type 1 (HIV-1) mRNA translation is a complex process that uses the host translation machinery to synthesise viral proteins. Several mechanisms for HIV-1 mRNA translation initiation have been proposed including (1) cap-dependent, eIF4E...

...Charlotte Mahiet; Chad M. Swanson Cellular proteins are required for all steps of human immunodeficiency virus type 1 (HIV-1) gene expression including transcription, splicing, 3′-end formation/polyadenylation, nuclear export and translation. SR proteins are a family of cellular RNA-binding...

.... Identification of an inhibitory budding signal that blocks the release of HIV particles and exosome/microvesicle proteins Mol. Biol. Cell 2011 22 817 830 20 Gan X. Gould S.J. HIV Pol inhibits HIV budding and mediates the severe budding defect of Gag-Pol PLoS ONE 2012 7 e29421 21...

...Anna G. Drannik; Bethany M. Henrick; Kenneth L. Rosenthal Despite tremendous advances in our understanding of HIV/AIDS since the first cases were reported 30 years ago, we are still a long way from understanding critical steps of HIV acquisition, pathogenesis and correlates of protection. Our new...

..., and the subsequent assembly and release of infectious virus particles, is co-coordinated through interactions between the viral structural proteins and cellular proteins. In the present paper, we consider how these events occur during HIV production in macrophages. In these cells, virus assembly appears to occur...

... with MCPs, truncation of CCL11 by CD26 caused reduced binding to and signalling through CCR3 and hence impaired chemotactic activity for eosinophils [ 46 ]. However, truncated CCL11 retained antiviral activity against HIV-2 strains. Truncation of CCL5 by CD26 resulted in the reduction of its CCR3 as well...

... genetic disease HIV nucleolus DMPK, dystrophica myotonica-protein kinase MDM2, murine double minute 2 Ribozymes and RNA Catalysis: Focused Meeting Organized by D. M. J. Lilley (Department of Biochemistry, University of Dundee) and F. Eckstein (Max-Planck Institute for Experimental...