... and their binding to ECM may also facilitate their uptake by non-tumorigenic cells and thus affect them [ 55 ]. On the whole, as HIV-1 takes advantage of NEIs to facilitate delivery of its viral core into the host nucleus, the role of the Spathasome and VOR complex seems to extend beyond the EV field and may...

... frequencies in HIV-1 are the CD56 − CD16 + NK cells, and this population's association with chronic virus infections is the subject of this review. Human NK cells are classically defined by CD56 expression, yet increasing evidence supports the NK cell status of the CD56 − CD16 + subset which we discuss herein...

... on behalf of the Biochemical Society 2017 cytokinesis ESCRT HIV-1 midbody nuclear envelope Seminal work in yeast identified the endosomal sorting complex required for transport (ESCRT) through a series of studies of ∼40 vacuolar protein sorting ( VPS ) mutants that showed defective sorting...

...Elena Herrera-Carrillo; Ben Berkhout Human immunodeficiency virus type 1 (HIV-1) infection can be effectively controlled by potent antiviral drugs, but this never results in a cure. The patient should therefore take these drugs for the rest of his/her life, which can cause drug-resistance...

...Markus Thali By virtue of their multiple interactions with partner proteins and due to their strong propensity to multimerize, tetraspanins create scaffolds in membranes, recruiting or excluding specific proteins needed for particular cellular processes. We and others have shown that (i) HIV-1...

...Yoshiko Usami; Sergei Popov; Elena Popova; Michio Inoue; Winfried Weissenhorn; Heinrich G. Göttlinger HIV-1 Gag engages components of the ESCRT (endosomal sorting complex required for transport) pathway via so-called L (late-assembly) domains to promote virus budding. Specifically, the PTAP (Pro...

...P. M. Sharp; E. Bailes; F. Gao; B. E. Beer; V. M. Hirsch; B. H. Hahn The primate lentiviruses comprise SIV strains from various host species, as well as two viruses, HIV-1 and HIV-2, that cause AIDS in humans. The origins of HIV-1 and HIV-2 have been traced to cross-species transmissions from...