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Keywords: HIV-1
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Biochem Soc Trans (2023) 51 (3): 1201–1212.
Published: 04 May 2023
... frequencies in HIV-1 are the CD56 − CD16 + NK cells, and this population's association with chronic virus infections is the subject of this review. Human NK cells are classically defined by CD56 expression, yet increasing evidence supports the NK cell status of the CD56 − CD16 + subset which we discuss herein...
Biochem Soc Trans (2017) 45 (3): 613–634.
Published: 15 June 2017
.... Detailed functional analysis of HIV-1, murine leukaemia virus (MLV) and EIAV assembly has shown that viral budding requires only a small subset of the 12 mammalian ESCRT-III subunits. In particular, a prominent role for CHMP2 and CHMP4 family members in L-domain activity has been demonstrated for HIV-1...
Biochem Soc Trans (2011) 39 (2): 529–531.
Published: 22 March 2011
...Markus Thali By virtue of their multiple interactions with partner proteins and due to their strong propensity to multimerize, tetraspanins create scaffolds in membranes, recruiting or excluding specific proteins needed for particular cellular processes. We and others have shown that (i) HIV-1...
Biochem Soc Trans (2009) 37 (1): 181–184.
Published: 20 January 2009
...Yoshiko Usami; Sergei Popov; Elena Popova; Michio Inoue; Winfried Weissenhorn; Heinrich G. Göttlinger HIV-1 Gag engages components of the ESCRT (endosomal sorting complex required for transport) pathway via so-called L (late-assembly) domains to promote virus budding. Specifically, the PTAP (Pro...
Biochem Soc Trans (2000) 28 (2): 275–282.
Published: 01 February 2000
...P. M. Sharp; E. Bailes; F. Gao; B. E. Beer; V. M. Hirsch; B. H. Hahn The primate lentiviruses comprise SIV strains from various host species, as well as two viruses, HIV-1 and HIV-2, that cause AIDS in humans. The origins of HIV-1 and HIV-2 have been traced to cross-species transmissions from...