... of the Biochemical Society 2024 autophagy ISR neurons nutrient stress proteome UPR In response to nutrient scarcity, cells adapt to stress by modulating the balance between protein synthesis through mRNA transcription-translation and protein degradative pathways [ 11–13 ]. Although protein...

...Glenn R. Masson Cells must be able to sense and adapt to their surroundings to thrive in a dynamic environment. Key to adapting to a low nutrient environment is the Integrated Stress Response (ISR), a short-lived pathway that allows cells to either regain cellular homeostasis or facilitate...