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Keyword: Kelch-like ECH-associated protein 1 (Keap1)
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Articles
Biochem Soc Trans (2015) 43 (4): 650-656.
Published: 03 August 2015
... leiomyomatosis and renal cell cancer (HLRCC) hereditary tyrosinemia type 1 Kelch-like ECH-associated protein 1 (KEAP1) nuclear erythroid 2-like 2 transcription factor (NRF2) Deregulation of cellular redox balance has been implicated in many diseases including cancer, cardiovascular diseases and...
Articles
Biochem Soc Trans (2015) 43 (4): 657-662.
Published: 03 August 2015
...; published by Portland Press Limited 2015 antioxidant response element hazard assessment Kelch-like ECH-associated protein 1 (Keap1) nuclear factor erythroid 2-related factor 2 (Nrf2) stress response toxicity The process of evolution has enabled mammalian cells to withstand continuous...
Articles
Biochem Soc Trans (2015) 43 (4): 674-679.
Published: 03 August 2015
... been proposed as a therapeutic intervention in a range of chronic neurodegenerative conditions and cancer chemoprevention. One of the main mechanisms by which Nrf2 is negatively regulated involves an interaction with the ubiquitination facilitator protein, Kelch-like ECH-associated protein 1 (Keap1...
Articles
Biochem Soc Trans (2015) 43 (4): 639-644.
Published: 03 August 2015
... (email dic16@pitt.edu ) . 13 2 2015 © 2015 Authors; published by Portland Press Limited 2015 cancer Kelch-like ECH-associated protein 1 (Keap1) lipogenesis metabolism nuclear erythroid factor 2-like 2 (Nrf2) pentose phosphate pathway Nuclear erythroid factor 2-like 2...
Articles
Biochem Soc Trans (2015) 43 (4): 621-626.
Published: 03 August 2015
... kinase beta (IKKβ) Kelch-like ECH-associated protein 1 (Keap1) nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear factor-κB (NF-κB) neurodegeneration Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor controlling many aspects of cell homoeostasis in...
Articles
Biochem Soc Trans (2015) 43 (4): 645-649.
Published: 03 August 2015
...Hanna M. Leinonen; Emilia Kansanen; Petri Pölönen; Merja Heinäniemi; Anna-Liisa Levonen Accumulating evidence suggests that dysregulation of the Kelch-like ECH-associated protein 1 (Keap1)–nuclear factor E2-related factor 2 (Nrf2) pathway resulting in constitutively active Nrf2 and increased...
Articles
Biochem Soc Trans (2015) 43 (4): 680-686.
Published: 03 August 2015
...-stress conditions, Nrf2 is under tight regulation by the ubiquitin proteasome system (UPS). Detailed mechanistic investigations have shown the Kelch-like ECH-associated protein 1 (Keap1)–cullin3 (Cul3)–ring-box1 (Rbx1) E3-ligase to be the primary Nrf2 regulatory system. Recently, both beta-transducin...