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Keywords: MET
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Articles

State of the structure address on MET receptor activation by HGF

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Edmond M. Linossi, Gabriella O. Estevam, Masaya Oshima, James S. Fraser, Eric A. Collisson, Natalia Jura
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 645–661.
https://doi.org/10.1042/BST20200394
Published: 16 April 2021
...Edmond M. Linossi; Gabriella O. Estevam; Masaya Oshima; James S. Fraser; Eric A. Collisson; Natalia Jura The MET receptor tyrosine kinase (RTK) and its cognate ligand hepatocyte growth factor (HGF) comprise a signaling axis essential for development, wound healing and tissue homeostasis. Aberrant...
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Articles

The role of the HGF/Met axis in mesothelioma

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Thivyan Thayaparan, James F. Spicer, John Maher
Journal: Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 363–370.
https://doi.org/10.1042/BST20150252
Published: 11 April 2016
... of this cancer. In the majority of mesotheliomas, up-regulated expression or signalling by Met, the receptor for hepatocyte growth factor (HGF) can be demonstrated. Following binding of ligand, Met relays signals that promote cell survival, proliferation, movement, invasiveness, branching morphogenesis...
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