... with diabetes remains unchanged. There is increasing appreciation of the importance of the post translational modification by O-linked-N-acetylglucosamine (O-GlcNAc) of serine and threonine residues on proteins in regulating cardiomyocyte function and mediating stress responses. In response to diabetes...

...Yun Ge; Christina M. Woo O- linked N -acetylglucosamine ( O- GlcNAc) is a widespread reversible modification on nucleocytoplasmic proteins that plays an important role in many biochemical processes and is highly relevant to numerous human diseases. The O- GlcNAc modification has diverse functional...

...Yi Zhu; Gerald W. Hart O-linked-β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (PTM) that is actively added to and removed from thousands of intracellular proteins. As a PTM, O-GlcNAcylation tunes the functions of a protein in various ways, such as enzymatic activity...

... the circadian clock. Correspondence: Xiaoyong Yang ( [email protected] ) 23 2 2017 4 5 2017 16 5 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 circadian clock metabolism O -GlcNAc post-translational...

...Shweta Varshney; Pamela Stanley Here, we describe a recently discovered O -GlcNAc transferase termed EOGT for EGF domain-specific O -GlcNAc transferase. EOGT transfers GlcNAc ( N -acetylglucosamine) to Ser or Thr in secreted and membrane proteins that contain one or more epidermal growth factor...

... in the architecture of chromatin, thus controlling in fine the accessibility of the machinery of transcription, replication or DNA repair to the chromatin. Over the past decade, the nutrient-sensor enzyme O -GlcNAc transferase (OGT) has emerged as a modulator of chromatin remodeling. In mammals, OGT acts either...

...JaLessa N. Wright; Helen E. Collins; Adam R. Wende; John C. Chatham The post-translational modification of serine and threonine residues of proteins found in numerous subcellular locations by O -linked N -acetylglucosamine ( O -GlcNAc) is emerging as a key mediator of many cardiovascular...

... and duplication. In recent years, researchers have become increasingly interested in understanding how O -GlcNAc regulates the cell cycle. The O -GlcNAc post-translation modification is an O -glycosidic bond of a single β- N -acetylglucosamine sugar to serine/threonine residues of intracellular proteins...

...Moriah Eustice; Michelle R. Bond; John A. Hanover The dynamic carbohydrate post-translational modification (PTM) O -linked β- N -acetyl glucosamine ( O -GlcNAc) is found on thousands of proteins throughout the nucleus and cytoplasm, and rivals phosphorylation in terms of the number of substrates...