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Keyword: Orai
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Biochem Soc Trans (2016) 44 (2): 534–540.
Published: 11 April 2016
... functional implications, with special emphasis on the emerging contributions of cryo-ET. 1 email ruben@biochem.mpg.de 15 1 2016 © 2016 Authors; published by Portland Press Limited 2016 cryo-EM extended-synaptotagmin lipid transfer Orai ryanodine receptor STIM...
Biochem Soc Trans (2012) 40 (1): 119–123.
Published: 19 January 2012
... instances STIM2) that serves as the endoplasmic reticulum Ca 2+ sensor, and Orai (Orai1, Orai2 and Orai3) which function as pore-forming subunits of the store-operated channel. It has been known for some time that store-operated Ca 2+ entry is shut down during cell division. Recent work has revealed complex...
Biochem Soc Trans (2012) 40 (1): 279–281.
Published: 19 January 2012
... flight circuit inositol 1,4,5-trisphosphate receptor (IP 3 R) intracellular calcium neuromodulator Orai stromal interaction molecule (STIM) Changes in cellular Ca 2+ concentration affect multiple signalling processes in both excitable and non-excitable cells [ 1 ]. Ca 2+ signals can...
Biochem Soc Trans (2012) 40 (1): 112–118.
Published: 19 January 2012
... formation of higher-order STIM1 oligomers that move towards the PM and exposes activating domains in STIM1 cytosolic tail that bind to Ca 2+ channels of the Orai family at the PM and induce their activation. Both SOCE and STIM1 oligomerization are reversible events, but whether restoring normal [Ca 2+ ] ER...