...Lena Duma; Ivan Ahel ADP-ribosylation is a post-translational modification involved in DNA damage response (DDR). In higher organisms it is synthesised by PARP 1–3, DNA strand break sensors. Recent advances have identified serine residues as the most common targets for ADP-ribosylation during DDR...

... index. A more exciting approach is to exploit cancer-specific defects in the DDR, that represent vulnerabilities in the tumour and an opportunity to selectively target the tumour. PARP inhibitors (PARPi) selectively kill homologous recombination repair defective (HRD, e.g. through BRCA mutation) cells...

... of protein deacetylases and the PARP family of DNA repair enzymes. Whilst their vital activity consumes NAD + which is cleaved to nicotinamide, several pathways exist for re-generating NAD + and sustaining NAD + homeostasis. However, there is growing evidence of perturbed NAD + homeostasis and NAD...