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Keywords: PARP
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Biochem Soc Trans (2023) 51 (3): 995–1008.
Published: 12 May 2023
...Lena Duma; Ivan Ahel ADP-ribosylation is a post-translational modification involved in DNA damage response (DDR). In higher organisms it is synthesised by PARP 1–3, DNA strand break sensors. Recent advances have identified serine residues as the most common targets for ADP-ribosylation during DDR...
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Biochem Soc Trans (2023) 51 (1): 207–221.
Published: 06 January 2023
... index. A more exciting approach is to exploit cancer-specific defects in the DDR, that represent vulnerabilities in the tumour and an opportunity to selectively target the tumour. PARP inhibitors (PARPi) selectively kill homologous recombination repair defective (HRD, e.g. through BRCA mutation) cells...