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Keywords: PDAC
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Articles

The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction

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Jennifer E. Klomp, Jeff A. Klomp, Channing J. Der
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 253–267.
https://doi.org/10.1042/BST20200507
Published: 05 February 2021
.... Correspondence: Channing J. Der ( [email protected] ) 13 10 2020 30 12 2020 8 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 extracellular signal-regulated kinases mitogen-activated protein kinases PDAC RAS GTPase...
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Articles

RAS in pancreatic cancer

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Simone Lanfredini, Asmita Thapa, Eric O'Neill
Journal: Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (4): 961–972.
https://doi.org/10.1042/BST20170521
Published: 24 July 2019
... include pancreatic ductal adenocarcinoma (PDAC) and acinar cell carcinoma. PDAC is the most common type of pancreatic cancer and one of the leading causes of cancer-related death. It has been shown that less than 3% of PDAC patients have an overall survival of up to 5 years in the U.K. This mainly arises...
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