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Keywords: PIKfyve
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Biochem Soc Trans (2016) 44 (1): 185–190.
Published: 09 February 2016
... to their pivotal role in membrane dynamics, phosphoinositide de-regulation contributes to various human diseases. In this review, we will focus on the newly emerging regulation of the PIKfyve complex, a phosphoinositide kinase that converts the endosomal phosphatidylinositol-3-phosphate [PI(3) P...
Biochem Soc Trans (2016) 44 (1): 177–184.
Published: 09 February 2016
... to stimuli. A large complex of proteins that includes the lipid kinase Fab1–PIKfyve, dynamically regulates the levels of PI(3,5) P 2 . Deficiencies in PI(3,5) P 2 are linked to some human diseases, especially those of the nervous system. Future studies will probably determine new, undiscovered regulatory...
Biochem Soc Trans (2005) 33 (2): 346–349.
Published: 01 April 2005
... in bringing about this effect. For example, we do not know precisely where in the GLUT4 trafficking pathway this kinase acts. Nor do we know which protein substrates are responsible for mediating the effects of protein kinase B, although two recently identified proteins (AS160 and PIKfyve) may play a role...