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Keywords: PROTAC
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Articles

Recent insight into the role of RING-finger E3 ligases in glioma

Available to Purchase
Yang Cao, Hang Zhou, Xiaoyu Chen, Yin Li, Junwen Hu, Guoyang Zhou, Lin Wang
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 519–529.
https://doi.org/10.1042/BST20201060
Published: 05 February 2021
... chimeric molecules (PROTACs) interfering with RING E3s as potential anticancer agents for glioma. Correspondence: Lin Wang ( [email protected] ) * These authors contributed equally to this work. 30 10 2020 7 1 2021 12 1 2021 © 2021 The Author(s). Published by Portland...
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Articles

Small molecules that target the ubiquitin system

Open Access
Hai Qiu Wu, David Baker, Huib Ovaa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 479–497.
https://doi.org/10.1042/BST20190535
Published: 20 March 2020
... protein degradation, including proteolysis targeting chimeras (PROTACs) [ 73 ], immunomodulatory drugs (IMiDs) [ 74 ], and specific and nongenetic IAP-dependent protein erasers (SNIPER) [ 75 , 76 ], harnesses the destructive power of the host cell ubiquitin machinery to eliminate unwanted disease-causing...
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