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Keyword: Parkin
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Articles
Biochem Soc Trans (2016) 44 (1): 212-227.
Published: 09 February 2016
... ). 1 12 2015 © 2016 Authors 2016 This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution Licence 3.0 . ubiquitin E3 ligase RING RBR Fanconi anemia Parkin Ubiquitination is a reversible post-translational...
Articles
Biochem Soc Trans (2015) 43 (2): 297-301.
Published: 07 April 2015
...Zoi Erpapazoglou; Olga Corti Mitochondrial dysfunction is a hallmark of both idiopathic and familial Parkinson's disease (PD). Mutations in the PARK2 and PARK6 genes, coding for the cytosolic E3 ubiquitin protein ligase Parkin and the mitochondrial serine/threonine kinase PINK1 [phosphatase and...
Articles
Biochem Soc Trans (2015) 43 (2): 302-307.
Published: 07 April 2015
... protein, provide a clear research target in iPSC-derived neurons. Recessively inherited Parkin and PTEN-induced putative kinase 1 (PINK1) mutations have been investigated in this context and the present review describes the first insights gained from studies in iPSC-derived dopaminergic neurons, which...
Articles
Biochem Soc Trans (2015) 43 (2): 269-274.
Published: 07 April 2015
...Thomas R. Caulfield; Fabienne C. Fiesel; Wolfdieter Springer The PINK1 (phosphatase and tensin homologue-induced putative kinase 1)/Parkin-dependent mitochondrial quality control pathway mediates the clearance of damaged organelles, but appears to be disrupted in Parkinson's disease (PD) [Springer...
Articles
Biochem Soc Trans (2015) 43 (2): 292-296.
Published: 07 April 2015
... and rotenone as well as from the PD related genes, including SNCA and LRRK2 , and then look at old and new evidence regarding the interplay between parkin and MTs. Data from experimental models and human cells point out that parkin regulates MT stability and strengthen the link between MTs and PD...
Articles
Biochem Soc Trans (2011) 39 (5): 1509-1513.
Published: 21 September 2011
... (ubiquitin–proteasome system) with the OMM. In yeast, Vms1 [VCP (valosin-containing protein) (p97)/Cdc48-associated mitochondrial-stress-responsive 1] protein recruits Cdc48/p97 to the OMM. In mammalian systems, the E3 ubiquitin ligase parkin regulates the recruitment of Cdc48/p97 to mitochondria, subsequent...
Articles
Biochem Soc Trans (2010) 38 (3): 789-795.
Published: 24 May 2010
... compilation © 2010 Biochemical Society 2010 clueless cytoskeleton FRIENDLY mitochondrial dynamics mitophagy Parkin The discovery of mitochondria cannot be attributed to a single person, because many of the granular bodies observed by cytologists during the years 1850–1890, and given a...
Articles
Biochem Soc Trans (2010) 38 (1): 144-149.
Published: 19 January 2010
... cellular proteins and organelles, the aggresome–autophagy pathway is increasingly recognized as a specialized type of induced autophagy that mediates selective clearance of misfolded and aggregated proteins under the conditions of proteotoxic stress. Recent evidence implicates PD-linked E3 ligase parkin as...
Articles
Biochem Soc Trans (2006) 34 (5): 749-753.
Published: 25 October 2006
...D.J. Moore Mutations in the parkin gene are a common cause of autosomal recessive early-onset parkinsonism. Parkin functions as an E3 ubiquitin ligase where it can polyubiquitinate a number of its protein substrates, thus targeting them for degradation by the 26 S proteasomal complex. Recent...