... to humans by Anopheles mosquitos, affects over 230 million people globally each year, resulting in over 600 000 deaths [ 1 ]. The vast majority of these deaths occur in African children under 5 years of age suffering from severe Plasmodium falciparum malaria [ 1 ]. Despite having the highest risk...

... of functionally related genes including 83 Plasmodium falciparum putatively exported proteins [ 6 ] and 73 predicted Plasmodium berghei kinases [ 7 ]. However, in order to systematically study gene function at a genome-scale, one has to move beyond the paradigm of knocking out one gene at a time. In 2016...

... simulate effects of drug-induced inhibition of reaction steps on the whole-body physiology. We illustrate the approach for glucose metabolism in malaria patients, by merging two detailed kinetic models for glucose metabolism in the parasite Plasmodium falciparum and the human red blood cell with a coarse...

..., activity and membrane binding. Proteome-scale discovery on Plasmodium falciparum schizonts has revealed a complement of more than 400 palmitoylated proteins, including those essential for host invasion and drug resistance. The wide regulatory affect on this species is endorsed by the presence of 12...

... with parasite-derived, surface-exposed proteases during cell invasion and traversal through the host's extracellular matrix. Malarial parasites (e.g. Plasmodium falciparum , the species responsible for most of the mortality caused by human malaria) appear to have taken things a stage further utilizing host...

... erythrocyte Plasmodium falciparum pregnancy-associated malaria VAR2CSA Malaria is one of the most devastating infectious diseases to affect humanity, causing more than one million deaths and 500 million serious cases each year [ 1 ]. The most deadly forms of malaria are caused by the parasite...

... Biochemical Society 2010 apicoplast endosymbiosis malaria Plasmodium falciparum plastid P. falciparum is the intracellular obligate parasite that causes the most virulent and prevalent form of human malaria, a major global disease. According to the World Health Organization (WHO) report...

...Srabasti J. Chakravorty; Katie R. Hughes; Alister G. Craig Cytoadherence of PRBCs ( Plasmodium falciparum -infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive...

...S. Günther; P.J. McMillan; L.J.M. Wallace; S. Müller The human malaria parasite Plasmodium falciparum possesses a single mitochondrion and a plastid-like organelle called the apicoplast. Both organelles contain members of the KADH (α-keto acid dehydrogenase) complexes – multienzyme complexes...