... BY) . phase separation PRMTs R-loops Tudor domains TDRD2 is also named as TDRKH, and it is single Tudor domain has been reported to interact with arginine-rich N-terminus of PIWIL1 and PIWIL4 [ 62 ], and the interaction is decreased when PRMT5 is silenced [ 82 ]. A structure study of TDRD2 Tudor...

... conflicts (TRCs). Unscheduled R-loops have been associated with increases in repressive epigenetic marks such as histone H3 serine 10 phosphorylation (H3S10P) and H3K9me2/3 ( Figure 2b ). R-loop-dependent H3S10P accumulation was found in R-loop-prone mutants in yeast, C. elegans and human cells...