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Keywords: RAS GTPase
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Articles

The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction

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Jennifer E. Klomp, Jeff A. Klomp, Channing J. Der
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 253–267.
https://doi.org/10.1042/BST20200507
Published: 05 February 2021
.... Correspondence: Channing J. Der ( [email protected] ) 13 10 2020 30 12 2020 8 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 extracellular signal-regulated kinases mitogen-activated protein kinases PDAC RAS GTPase...
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Articles

Inhibition of RAS: proven and potential vulnerabilities

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Mariyam Zuberi, Imran Khan, John P. O'Bryan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 1831–1841.
https://doi.org/10.1042/BST20190023
Published: 01 September 2020
... to be pharmacologically effective. allosteric inhibitor cancer chemotherapy dimerization monobody RAS GTPase RAS has been at the forefront of cancer research due to its prominence in the onset and progression of human cancers. Somatic mutations in RAS are a hallmark of many cancers with ∼19% of cancer...
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