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Keyword: RNA
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Articles
Biochem Soc Trans (2019) 47 (5): 1429-1436.
Published: 24 September 2019
... mitoribosome protein synthesis RNA translation Mitochondrial origins are normally considered to be proteobacteria, following endosymbiosis the characteristics of these organelles have demonstrated significant divergence between organisms [ 1 ]. Various functions have been conserved, some more highly...
Articles
Biochem Soc Trans (2019) 47 (2): 679-689.
Published: 05 March 2019
...Amber Riaz-Bradley Transcription in cyanobacteria involves several fascinating features. Cyanobacteria comprise one of the very few groups in which no proofreading factors (Gre homologues) have been identified. Gre factors increase the efficiency of RNA cleavage, therefore helping to maintain the...
Articles
Biochem Soc Trans (2018) 46 (5): 1073-1082.
Published: 21 September 2018
... RNA translation Interest in extracellular vesicles (EVs) has grown exponentially since their discovery over 30 years ago. EVs are lipid-enclosed vesicles that are able to act as a means of cellular communication, waste disposal and transfer of nucleic acids and protein. They are predominantly...
Articles
Biochem Soc Trans (2018) 46 (2): 329-341.
Published: 09 March 2018
...Frank Curmi; Ruben J. Cauchi Gemin3, also known as DDX20 or DP103, is a DEAD-box RNA helicase which is involved in more than one cellular process. Though RNA unwinding has been determined in vitro , it is surprisingly not required for all of its activities in cellular metabolism. Gemin3 is an...
Articles
Biochem Soc Trans (2017) 45 (4): 987-997.
Published: 14 July 2017
...Tom Dendooven; Ben F. Luisi RNA acts not only as an information bearer in the biogenesis of proteins from genes, but also as a regulator that participates in the control of gene expression. In bacteria, small RNA molecules (sRNAs) play controlling roles in numerous processes and help to orchestrate...
Articles
Biochem Soc Trans (2016) 44 (4): 1058-1065.
Published: 15 August 2016
... life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of the RNA recognition motif (RRM) family, each of which can bind to pyrimidine motifs. In addition, RRM2 can interact via its dorsal surface with proteins containing short peptide ligands known as PTB...
Articles
Biochem Soc Trans (2014) 42 (4): 985-988.
Published: 11 August 2014
...Markus Ralser An RNA world has been placed centre stage for explaining the origin of life. Indeed, RNA is the most plausible molecule able to form both a (self)-replicator and to inherit information, necessities for initiating genetics. However, in parallel with self-replication, the proto-organism...
Articles
Biochem Soc Trans (2012) 40 (4): 815-820.
Published: 20 July 2012
...Panagiota Kafasla; Ian Mickleburgh; Miriam Llorian; Miguel Coelho; Clare Gooding; Dmitry Cherny; Amar Joshi; Olga Kotik-Kogan; Stephen Curry; Ian C. Eperon; Richard J. Jackson; Christopher W.J. Smith PTB (polypyrimidine tract-binding protein) is an abundant and widely expressed RNA-binding protein...
Articles
Biochem Soc Trans (2012) 40 (4): 886-890.
Published: 20 July 2012
...Anna M. Hoy; Amy H. Buck miRNAs (microRNAs) are a class of small RNA that regulate gene expression by binding to mRNAs and modulating the precise amount of proteins that get expressed in a cell at a given time. This form of gene regulation plays an important role in developmental systems and is...
Articles
Biochem Soc Trans (2011) 39 (2): 575-580.
Published: 22 March 2011
...Marvin H. Caruthers Current methodologies used to synthesize DNA and RNA are reviewed. These focus on using controlled pore glass and microarrays on glass slides. 1 email Marvin.caruthers@colorado.edu 31 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011...
Articles
Biochem Soc Trans (2011) 39 (2): 635-640.
Published: 22 March 2011
... short review, we first describe the structural and dynamic parallels with complex RNA structures, including the importance of sequence and ions in folding, and then we describe the biological consequences of the folded structures. We conclude that there are considerable parallels between secondary and...
Articles
Biochem Soc Trans (2010) 38 (2): 381-383.
Published: 22 March 2010
...W. Marshall Stark; Ben F. Luisi; Richard P. Bowater As the vital information repositories of the cell, the nucleic acids DNA and RNA pose many challenges as enzyme substrates. To produce, maintain and repair DNA and RNA, and to extract the genetic information that they encode, a battery of...
Articles
Biochem Soc Trans (2009) 37 (6): 1261-1262.
Published: 19 November 2009
... steps required for a protein to be generated from a gene, and groups who focus on gene expression normally study a single step such as regulation of transcription, mechanisms of RNA processing or control of translation. To address this, experts were brought together at the Gene Expression in Neuronal...
Articles
Biochem Soc Trans (2009) 37 (2): e1-e4.
Published: 06 May 2009
... in Nucleic Acid Detection and Quantification’, and the primary aim was to bring together scientists from different disciplines who nevertheless are trying to develop reliable methods for the quantification or detection of RNA and DNA molecules. This meant that physical and organic chemists, microbial...
Articles
Biochem Soc Trans (2008) 36 (4): 567-574.
Published: 22 July 2008
... ramak@mrc-lmb.cam.ac.uk 21 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 antibiotic codon–anticodon pairing decoding ribosome RNA X-ray crystallography Ribosomes are large macromolecular assemblies consisting of approx. two-thirds by mass of...
Articles
Biochem Soc Trans (2008) 36 (3): 511-513.
Published: 21 May 2008
...-transcriptional processing of RNA. This work involves the integration of a number of bioinformatics resources, from comparing annotations to processing images to determining the structure of transcripts. The rapidly growing datasets of GeneChips available to the community puts us in a strong position to discover...
Articles
Biochem Soc Trans (2007) 35 (3): 623-625.
Published: 22 May 2007
... +/+ homozygotes born from Kit tm1Alf /+ heterozygotes maintain and transmit to their progeny the white-spotted phenotype characteristic of the mutant heterozygote. Our observation of unusual amounts of RNA in the sperm of the paramutated ( Kit *) males had led us to consider the possibility of RNA-mediated...
Articles
Biochem Soc Trans (2002) 30 (6): 1119-1122.
Published: 01 November 2002
...K. F. Blount; O. C. Uhlenbeck The hammerhead ribozyme is a small RNA motif consisting of three helices that intersect at a conserved core. When correctly folded, the hammerhead ribozyme stimulates nearly complete cleavage of the phosphodiester chain at a defined internal site to give 2′,3′-cyclic...