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Keywords: RNA
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Biochem Soc Trans (2021) 49 (6): 2853–2869.
Published: 16 December 2021
... Attribution License 4.0 (CC BY-NC-ND) . ageing protein biosynthesis ribosome RNA translation translational control Cellular ageing refers to the progressive deterioration of cellular functions over time, often leading to cell cycle arrest (senescence) or cell death [ 1–3 ]. Ageing...
Biochem Soc Trans (2021) 49 (6): 2591–2600.
Published: 25 November 2021
... by which cells can generate subcellular microenvironments with specialized gene expression profiles. Particularly intriguing are recent findings that phase separation plays a role in certain RNA localization pathways. The burgeoning field of phase separation has revolutionized how we view cellular...
Biochem Soc Trans (2021) 49 (1): 393–403.
Published: 25 January 2021
...Jeffrey M. Smith; Jarrod J. Sandow; Andrew I. Webb RNA-binding proteins are customarily regarded as important facilitators of gene expression. In recent years, RNA–protein interactions have also emerged as a pervasive force in the regulation of homeostasis. The compendium of proteins with provable...
Biochem Soc Trans (2020) 48 (5): 1941–1951.
Published: 01 September 2020
...Elizabeth C. Gray; Daniel M. Beringer; Michelle M. Meyer Structured cis-regulatory RNAs have evolved across all domains of life, highlighting the utility and plasticity of RNA as a regulatory molecule. Homologous RNA sequences and structures often have similar functions, but homology may also...
Biochem Soc Trans (2019) 47 (5): 1429–1436.
Published: 24 September 2019
... synthesis RNA translation Mitochondrial origins are normally considered to be proteobacteria, following endosymbiosis the characteristics of these organelles have demonstrated significant divergence between organisms [ 1 ]. Various functions have been conserved, some more highly than others...
Biochem Soc Trans (2019) 47 (2): 679–689.
Published: 05 March 2019
...Amber Riaz-Bradley Transcription in cyanobacteria involves several fascinating features. Cyanobacteria comprise one of the very few groups in which no proofreading factors (Gre homologues) have been identified. Gre factors increase the efficiency of RNA cleavage, therefore helping to maintain...
Biochem Soc Trans (2018) 46 (5): 1073–1082.
Published: 21 September 2018
... , 3 – 5 ]. The term exosome (not to be confused with the entirely distinct ‘exosome complex’ involved in RNA editing) was coined by Rose Johnstone in 1987 who observed sacs filled with smaller vesicles in maturing reticulocytes [ 6 ]. These larger sacs are today known as multi-vesicular bodies...
Biochem Soc Trans (2018) 46 (2): 329–341.
Published: 09 March 2018
...Frank Curmi; Ruben J. Cauchi Gemin3, also known as DDX20 or DP103, is a DEAD-box RNA helicase which is involved in more than one cellular process. Though RNA unwinding has been determined in vitro , it is surprisingly not required for all of its activities in cellular metabolism. Gemin3...
Biochem Soc Trans (2017) 45 (4): 987–997.
Published: 14 July 2017
...Tom Dendooven; Ben F. Luisi RNA acts not only as an information bearer in the biogenesis of proteins from genes, but also as a regulator that participates in the control of gene expression. In bacteria, small RNA molecules (sRNAs) play controlling roles in numerous processes and help to orchestrate...
Biochem Soc Trans (2016) 44 (4): 1058–1065.
Published: 15 August 2016
... of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of the RNA recognition motif (RRM) family, each of which can bind to pyrimidine motifs. In addition, RRM2 can interact via its dorsal surface with proteins containing short peptide ligands known as PTB...
Biochem Soc Trans (2014) 42 (4): 985–988.
Published: 11 August 2014
...Markus Ralser An RNA world has been placed centre stage for explaining the origin of life. Indeed, RNA is the most plausible molecule able to form both a (self)-replicator and to inherit information, necessities for initiating genetics. However, in parallel with self-replication, the proto-organism...
Biochem Soc Trans (2012) 40 (4): 815–820.
Published: 20 July 2012
...Panagiota Kafasla; Ian Mickleburgh; Miriam Llorian; Miguel Coelho; Clare Gooding; Dmitry Cherny; Amar Joshi; Olga Kotik-Kogan; Stephen Curry; Ian C. Eperon; Richard J. Jackson; Christopher W.J. Smith PTB (polypyrimidine tract-binding protein) is an abundant and widely expressed RNA-binding protein...
Biochem Soc Trans (2012) 40 (4): 886–890.
Published: 20 July 2012
...Anna M. Hoy; Amy H. Buck miRNAs (microRNAs) are a class of small RNA that regulate gene expression by binding to mRNAs and modulating the precise amount of proteins that get expressed in a cell at a given time. This form of gene regulation plays an important role in developmental systems...
Biochem Soc Trans (2011) 39 (2): 635–640.
Published: 22 March 2011
... short review, we first describe the structural and dynamic parallels with complex RNA structures, including the importance of sequence and ions in folding, and then we describe the biological consequences of the folded structures. We conclude that there are considerable parallels between secondary...
Biochem Soc Trans (2011) 39 (2): 575–580.
Published: 22 March 2011
...Marvin H. Caruthers Current methodologies used to synthesize DNA and RNA are reviewed. These focus on using controlled pore glass and microarrays on glass slides. It is clear that synthetic DNAs, and more recently RNAs, have become indispensable tools for achieving major advances in biology...
Biochem Soc Trans (2010) 38 (2): 381–383.
Published: 22 March 2010
...W. Marshall Stark; Ben F. Luisi; Richard P. Bowater As the vital information repositories of the cell, the nucleic acids DNA and RNA pose many challenges as enzyme substrates. To produce, maintain and repair DNA and RNA, and to extract the genetic information that they encode, a battery...
Biochem Soc Trans (2009) 37 (6): 1261–1262.
Published: 19 November 2009
... steps required for a protein to be generated from a gene, and groups who focus on gene expression normally study a single step such as regulation of transcription, mechanisms of RNA processing or control of translation. To address this, experts were brought together at the Gene Expression in Neuronal...
Biochem Soc Trans (2009) 37 (2): e1–e4.
Published: 06 May 2009
... in Nucleic Acid Detection and Quantification’, and the primary aim was to bring together scientists from different disciplines who nevertheless are trying to develop reliable methods for the quantification or detection of RNA and DNA molecules. This meant that physical and organic chemists, microbial...
Biochem Soc Trans (2008) 36 (4): 567–574.
Published: 22 July 2008
... codon–anticodon pairing decoding ribosome RNA X-ray crystallography Ribosomes are large macromolecular assemblies consisting of approx. two-thirds by mass of RNA, with the rest being proteins. Given their molecular mass of approx. 2.5 MDa in bacteria, it was not clear whether it would ever...
Biochem Soc Trans (2008) 36 (3): 511–513.
Published: 21 May 2008
...-transcriptional processing of RNA. This work involves the integration of a number of bioinformatics resources, from comparing annotations to processing images to determining the structure of transcripts. The rapidly growing datasets of GeneChips available to the community puts us in a strong position to discover...
Biochem Soc Trans (2007) 35 (3): 623–625.
Published: 22 May 2007
... +/+ homozygotes born from Kit tm1Alf /+ heterozygotes maintain and transmit to their progeny the white-spotted phenotype characteristic of the mutant heterozygote. Our observation of unusual amounts of RNA in the sperm of the paramutated ( Kit *) males had led us to consider the possibility of RNA-mediated...
Biochem Soc Trans (2002) 30 (6): 1119–1122.
Published: 01 November 2002
...K. F. Blount; O. C. Uhlenbeck The hammerhead ribozyme is a small RNA motif consisting of three helices that intersect at a conserved core. When correctly folded, the hammerhead ribozyme stimulates nearly complete cleavage of the phosphodiester chain at a defined internal site to give 2′,3′-cyclic...