...Amy L. Pashler; Benjamin P. Towler; Christopher I. Jones; Sarah F. Newbury RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases that are critical for the degradation...

... in this organelle remain largely elusive. Here, we summarize the present knowledge of how RNA is degraded in human mitochondria and describe the coexistence of stable poly(A) tails and the nonabundant tails, which have been suggested to play a role in the RNA degradation process. Figure 3. The polyadenylation...

... exonuclease exosome RNA degradation RNA processing RNA surveillance The exosome is a multiprotein nuclease complex that functions in RNA processing and turnover. This complex was first discovered in Saccharomyces cerevisiae and has been extensively studied in this organism, whereas the functions...

...Jonathan Houseley Unstable non-coding RNAs are produced from thousands of loci in all studied eukaryotes (and also prokaryotes), but remain of largely unknown function. The present review summarizes the mechanisms of eukaryotic non-coding RNA degradation and highlights recent findings regarding...

... correspondence should be addressed (email [email protected] ). 20 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cell cycle DNA replication histone gene expression RNA degradation RNA processing translation Figure 1 Key steps and factors...

... exosome helicase polyadenylation RNA degradation Figure 1 Crystal structures of bacterial PNPase, archaeal exosome and human nine-subunit exosome The exosome is evolutionarily conserved. PH-like domains are shown in green (Rrp41 homologue, light green; Rrp42 homologue, dark green...