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Keywords: RNA polymerase
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1695–1702.
Published: 09 August 2024
... Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. bursting enhancers LLPS parameter inference RNA polymerase transcription Transcriptional bursting has become a popular concept in recent years. It refers...
Articles
The initiation of mitochondrial DNA replication
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1243–1251.
Published: 17 June 2024
...Yi Liu; Haibin Liu; Fan Zhang; Hong Xu Mitochondrial DNA replication is initiated by the transcription of mitochondrial RNA polymerase (mtRNAP), as mitochondria lack a dedicated primase. However, the mechanism determining the switch between continuous transcription and premature termination...
Articles
Epigenetic regulation of human non-coding RNA gene transcription
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 723–736.
Published: 14 March 2022
... of ncRNA gene transcription by the three human nuclear RNA polymerases. Emerging common features, like the heterogeneity of chromatin states within ncRNA multigene families and their influence on 3D genome organization, point to unexplored issues whose investigation could lead to a better understanding...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1569–1581.
Published: 29 July 2020
... a transcription apparatus including a eukaryote-like RNA polymerase along with a combination of virus-specific, and host-related transcription factors homologous to the TATA-binding protein (TBP) and TFIIB. Despite its high impact, the molecular basis and temporal regulation of ASFV transcription is not well...
Articles
Bacteriophage gene products as potential antimicrobials against tuberculosis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (3): 847–860.
Published: 13 May 2019
... to rifampicin via mutation of RNA polymerase (RNAP) at the rifampicin-binding pocket [ 6 ]. Strains resistant to at least rifampicin and isoniazid are considered multidrug-resistant (MDR). Drugs which are currently used in clinical trials, such as bedaquiline (inhibition of ATP synthase), delamanid (cell wall...
Articles
Transcription initiation factor TBP: old friend new questions
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 411–423.
Published: 01 February 2019
...Kevin Kramm; Christoph Engel; Dina Grohmann In all domains of life, the regulation of transcription by DNA-dependent RNA polymerases (RNAPs) is achieved at the level of initiation to a large extent. Whereas bacterial promoters are recognized by a σ-factor bound to the RNAP, a complex set...
Articles
Mechanisms of antibiotics inhibiting bacterial RNA polymerase
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 339–350.
Published: 15 January 2019
...Hamed Mosaei; John Harbottle Transcription, the first phase of gene expression, is performed by the multi-subunit RNA polymerase (RNAP). Bacterial RNAP is a validated target for clinical antibiotics. Many natural and synthetic compounds are now known to target RNAP, inhibiting various stages...
Articles
New insights into the adaptive transcriptional response to nitrogen starvation in Escherichia coli
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1721–1728.
Published: 04 December 2018
... RNA polymerase transcriptomics Conditions that sustain constant bacterial growth are seldom found in nature. Bacterial growth is often limited by the availability of nutrients: soil, water, and even host environments such as macrophages can lack essential nutrients to support growth. Hence...
Articles
Electron microscopy studies of Type III CRISPR machines in Sulfolobus solfataricus
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1427–1430.
Published: 20 November 2013
... Biochemical Society 2013 clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) CRISPR RNA (crRNA) RecA RNA polymerase Type III CRISPR In prokaryotes, CRISPRs (clustered regularly interspaced short palindromic repeats) are involved in an interference...
Articles
Archaeal transcription: making up for lost time
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 356–361.
Published: 29 January 2013
...Magdalena N. Wojtas; Nicola G.A. Abrescia In recent years, emerging structural information on the a RNAP (archaeal RNA polymerase) apparatus has shown its strong evolutionary relationship with the eukaryotic counterpart, RNA Pol (polymerase) II. A novel atomic model of Ssh RNAP ( Sulfolobus...
Articles
Archaeology of RNA polymerase: factor swapping during the transcription cycle
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 362–367.
Published: 29 January 2013
...Fabian Blombach; Tina Daviter; Daniel Fielden; Dina Grohmann; Katherine Smollett; Finn Werner All RNAPs (RNA polymerases) repeatedly make use of their DNA template by progressing through the transcription cycle multiple times. During transcription initiation and elongation, distinct sets...
Articles
Archaeal RNA polymerase: the influence of the protruding stalk in crystal packing and preliminary biophysical analysis of the Rpo13 subunit
Available to PurchaseMagdalena Wojtas, Bibiana Peralta, Marina Ondiviela, Maria Mogni, Stephen D. Bell, Nicola G.A. Abrescia
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 25–30.
Published: 19 January 2011
...Magdalena Wojtas; Bibiana Peralta; Marina Ondiviela; Maria Mogni; Stephen D. Bell; Nicola G.A. Abrescia We review recent results on the complete structure of the archaeal RNAP (RNA polymerase) enzyme of Sulfolobus shibatae . We compare the three crystal forms in which this RNAP packs (space groups...
Articles
Cation–π interactions induce kinking of a molecular hinge in the RNA polymerase bridge–helix domain
Available to PurchaseHans Heindl, Pamela Greenwell, Noam Weingarten, Tamas Kiss, Gabor Terstyanszky, Robert O.J. Weinzierl
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 31–35.
Published: 19 January 2011
...Hans Heindl; Pamela Greenwell; Noam Weingarten; Tamas Kiss; Gabor Terstyanszky; Robert O.J. Weinzierl RNAPs (RNA polymerases) are complex molecular machines that contain a highly conserved catalytic site surrounded by conformationally flexible domains. High-throughput mutagenesis in the archaeal...
Articles
FRET (fluorescence resonance energy transfer) sheds light on transcription
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 122–127.
Published: 19 January 2011
...Dina Grohmann; Daniel Klose; Daniel Fielden; Finn Werner The complex organization of the transcription machinery has been revealed mainly by biochemical and crystallographic studies. X-ray structures describe RNA polymerases and transcription complexes on an atomic level, but fail to portray...
Articles
Cross-talk in transcription, splicing and chromatin: who makes the first call?
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1251–1256.
Published: 24 September 2010
... compilation © 2010 Biochemical Society 2010 coupling histone modification nucleosome RNA polymerase small nuclear ribonucleoprotein particle (snRNP) spliceosome When protein encoding transcripts are produced by RNAPII (RNA polymerase II), they are subject to processing at their 5′-ends...
Articles
Nanomechanical constraints acting on the catalytic site of cellular RNA polymerases
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 428–432.
Published: 22 March 2010
...Robert O.J. Weinzierl RNAPs (RNA polymerases) are complex molecular machines containing structural domains that co-ordinate the movement of nucleic acid and nucleotide substrates through the catalytic site. X-ray images of bacterial, archaeal and eukaryotic RNAPs have provided a wealth...
Articles
Molecular mechanisms of archaeal RNA polymerase
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 12–17.
Published: 20 January 2009
...Dina Grohmann; Angela Hirtreiter; Finn Werner All cellular life depends on multisubunit RNAPs (RNA polymerases) that are evolutionarily related through the three domains of life. Archaeal RNAPs encompass 12 subunits that contribute in different ways to the assembly and stability of the enzyme...
Articles
Mutational studies of archaeal RNA polymerase and analysis of hybrid RNA polymerases
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 18–22.
Published: 20 January 2009
...Michael Thomm; Christoph Reich; Sebastian Grünberg; Souad Naji The recent success in reconstitution of RNAPs (RNA polymerases) from hyperthermophilic archaea from bacterially expressed purified subunits opens the way for detailed structure–function analyses of multisubunit RNAPs. The archaeal...
Articles
Transcription factories: structures conserved during differentiation and evolution
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1133–1137.
Published: 25 October 2006
...I. Faro-Trindade; P.R. Cook Many cellular functions take place in discrete compartments, but our textbooks make little reference to any compartments involved in transcription. We review the evidence that active RNA polymerases and associated factors cluster into ‘factories’ that carry out many...
Articles
A second paradigm for gene activation in bacteria
Available to PurchaseM. Buck, D. Bose, P. Burrows, W. Cannon, N. Joly, T. Pape, M. Rappas, J. Schumacher, S. Wigneshweraraj, X. Zhang
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1067–1071.
Published: 25 October 2006
... within a transcriptional activator can lead to DNA opening and transcription. The bacterial EBPs (enhancer binding proteins) that belong to the AAA + (ATPases associated with various cellular activities) protein family remodel the RNAP (RNA polymerase) holoenzyme containing the σ 54 factor and convert...
Articles
Recruitment of RNA polymerase to Class II CRP-dependent promoters is improved by a second upstream-bound CRP molecule
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1075–1078.
Published: 25 October 2006
...-bound CRP molecule. We show that the upstream-bound CRP contributes to transcription activation by improving the recruitment of RNA polymerase. 1 To whom correspondence should be addressed (email [email protected] ). 9 6 2006 © 2006 The Biochemical Society 2006 activation...
Articles
Recent structural studies of RNA polymerases II and III
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1058–1061.
Published: 25 October 2006
...P. Cramer Here, I review three new structural studies from our laboratory. First, the crystal structure of RNA polymerase (Pol) II in complex with an RNA inhibitor revealed that this RNA blocks transcription initiation by preventing DNA loading into the active-centre cleft. Secondly, the structure...
Articles
An in silico analysis of trypanosomatid RNA polymerases: insights into their unusual transcription
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1435–1437.
Published: 26 October 2005
...S. Kelly; B. Wickstead; K. Gull African trypanosomes employ both Pol I (RNA polymerase I) and Pol II to transcribe protein-coding genes in large polycistronic units of up to 50 genes. Subsequent processing produces mature capped mRNAs. Evidence suggests that regulation of gene expression...
Articles
RNA interference and double-stranded-RNA-activated pathways
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 952–956.
Published: 26 October 2004
... for shortterm studies of gene expression, it cannot substitute for the utility of knockout mouse models. This is not a concern in organisms such as C. elegans , because they express an RNA-dependent RNA polymerase that facilitates the propagation of siRNA expression. In these systems, the suppressed phenotype...