... protein MAVS [ 14 ]. Activation of MAVS leads to a signaling cascade that drives a type I interferon (IFN-I) response including the expression of many interferon stimulated genes (ISGs). autoimmunity cancer innate immunity RNA editing RNA-binding proteins therapeutics In the 1890s Dr...

...Macy L. Sprunger; Meredith E. Jackrel The dysfunction of many RNA-binding proteins (RBPs) that are heavily disordered, including TDP-43 and FUS, are implicated in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). These proteins serve many important roles in the cell...

... ribonucleoprotein D (HNRPD/Auf1), poly(C)-binding protein (PCBP1/HNRNP E1), and Y-box binding protein 1 (YB-1) have been identified as four RNA-binding proteins that preferentially bind 8-oxoG-modified RNA over unmodified RNA. All four proteins are native to humans and PNPase is additionally found in bacteria...

...Cécile Bousquet-Antonelli RNA binding proteins, through control of mRNA fate and expression, are key players of organism development. The LARP family of RBPs sharing the La motif, are largely present in eukaryotes. They classify into five subfamilies which members acquired specific additional...

...Jeffrey M. Smith; Jarrod J. Sandow; Andrew I. Webb RNA-binding proteins are customarily regarded as important facilitators of gene expression. In recent years, RNA–protein interactions have also emerged as a pervasive force in the regulation of homeostasis. The compendium of proteins with provable...

... in their ancestors, the bacteria, this machinery does not use membrane-based compartmentalisation to order the gene expression pathway. Therefore, the lifecycle of mitochondrial RNAs from transcription through processing, maturation, translation to turnover is mediated by a gamut of RNA-binding proteins (RBPs), all...

... Society 2018 mRNA processing mRNP RNA-binding proteins spliceosome RNA-binding proteins are an integral part of messenger ribonucleoproteins and determine the fate of mRNAs in the cell [ 1 ]. A prominent example is the exon junction complex (EJC) which is deposited at exon-exon junctions...

... and elongation factors, RNA-binding proteins (RBPs) provide a crucial additional layer to post-transcriptional regulation. RBPs bind specific RNA through conserved RNA-binding domains and ensure that the information contained within the genome and transcribed in the form of RNA is exported to the cytoplasm...

... illustrates examples of datasets where potentially novel ETC:miRNA interactions have been identified. eukaryotic gene expression metabolic regulation microRNA mitochondrial respiration RNA-binding proteins The control of metabolic homeostasis is central to maintaining the physiological...

... system) KHDRBS (KH domain RNA binding and signal transduction) neurexin RNA-binding proteins STAR (signal transduction and activation of RNA) T-star (also known as Slm2 and Khdrbs3) is expressed mainly in the brain and the testis [ 19 , 20 ]. Knockout mouse models missing T-star exon 2 have...

... ]. Alternative splice events are controlled in part by a number of different RNA-binding proteins attaching to pre-mRNAs, although links with transcription and epigenetic modification of the template chromatin are also important. A large group of splicing regulator proteins contain domains that are enriched...