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Keywords: RNA-binding proteins
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Biochem Soc Trans (2024) 52 (3): 961–972.
Published: 30 May 2024
...Macy L. Sprunger; Meredith E. Jackrel The dysfunction of many RNA-binding proteins (RBPs) that are heavily disordered, including TDP-43 and FUS, are implicated in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). These proteins serve many important roles in the cell...
Biochem Soc Trans (2021) 49 (5): 1975–1983.
Published: 28 October 2021
...Cécile Bousquet-Antonelli RNA binding proteins, through control of mRNA fate and expression, are key players of organism development. The LARP family of RBPs sharing the La motif, are largely present in eukaryotes. They classify into five subfamilies which members acquired specific additional...
Biochem Soc Trans (2018) 46 (5): 1239–1246.
Published: 09 October 2018
... in their ancestors, the bacteria, this machinery does not use membrane-based compartmentalisation to order the gene expression pathway. Therefore, the lifecycle of mitochondrial RNAs from transcription through processing, maturation, translation to turnover is mediated by a gamut of RNA-binding proteins (RBPs), all...
Biochem Soc Trans (2018) 46 (1): 153–161.
Published: 19 January 2018
... Society 2018 mRNA processing mRNP RNA-binding proteins spliceosome Reconstitution studies in vitro have provided valuable insights into the mechanism of EJC assembly and RNA binding [ 14 ]. In the presence of ATP, EIF4A3 adopts a closed conformation, in which it binds to the phosphate...
Biochem Soc Trans (2016) 44 (5): 1491–1498.
Published: 19 October 2016
... metabolic regulation microRNA mitochondrial respiration RNA-binding proteins The control of metabolic homeostasis is central to maintaining the physiological function and health of an organism. A key player in the maintenance of cellular homeostasis is the semi-autonomous mitochondria, which...
Biochem Soc Trans (2016) 44 (4): 1066–1072.
Published: 15 August 2016
... system) KHDRBS (KH domain RNA binding and signal transduction) neurexin RNA-binding proteins STAR (signal transduction and activation of RNA) Figure 1 The domain structure of the vertebrate STAR proteins The KH domain has homology to hnRNPK; QUA1 and QUA2 are domains with homology...
Biochem Soc Trans (2012) 40 (4): 784–788.
Published: 20 July 2012
... Journal compilation © 2012 Biochemical Society 2012 development gene expression high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) RNA-binding proteins RNA splicing Tra2β transcriptome Alternative splicing introduces new coding information...