...Carolina Ortiz Sandoval; Thomas Simmen Whereas most of what we know today about the Ras-related small GTPases of the Rab family stems from observations made on Golgi complex, endosome and plasma membrane trafficking, a subset of Rabs localizes in part or predominantly to the ER (endoplasmic...

...Julia Blümer; Yao-Wen Wu; Roger S. Goody; Aymelt Itzen Despite over two decades of research, the mechanism of Rab targeting to specific intracellular membranes is still not completely understood. Present evidence suggests that the original hypothesis that the message for targeting resides solely...

...Eoin E. Kelly; Conor P. Horgan; Bruno Goud; Mary W. McCaffrey Intracellular membrane trafficking requires the complex interplay of several classes of trafficking proteins. Rab proteins, the largest subfamily of the Ras superfamily of small G-proteins, are central regulators of all aspects...

... Biochemical Society 2010 exocyst NADPH oxidase phospholipase D Rab Rop small GTPase Plant cell morphogenesis relies upon a dynamic network of processes integrating cell wall dynamics with signal transduction, changes in ion membrane transports, membrane lipid modifications, regulation...

... (email Romano.Regazzi@unil.ch ). 16 6 2006 © 2006 The Biochemical Society 2006 diabetes mellitus exocytotic apparatus inducible cAMP early repressor (ICER) microRNA (miRNA) Rab transcription factor Convergence of data obtained in different model systems including yeast...

... B (PKB) Rab Insulin is the primary hormone that is responsible for the control of glucose homoeostasis. One of the major effects of insulin is to stimulate the translocation of the glucose transporter isoform GLUT4 from an intracellular location to the plasma membrane [ 1 ]. This involves...

...B.R. Ali; M.C. Seabra Rab proteins are members of the superfamily of Ras-like small GTPases and are involved in several cellular processes relating to membrane trafficking and organelle mobility throughout the cell. Like other small GTPases, Rab proteins are initially synthesized as soluble...

...S. Pfeffer The human genome encodes almost 70 Rab GTPases. These proteins are C-terminally geranylgeranylated and are localized to the surfaces of distinct membrane-bound compartments in eukaryotic cells. This mini review presents a working model for how Rabs achieve and maintain their steady-state...