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Keywords: Rab GTPases
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Biochem Soc Trans (2019) 47 (6): 1581–1595.
Published: 26 November 2019
... multiple diseases associated with LRRK2 to highlight the pleiotropic effects of LRRK2 in different cell types. We discuss the role of the bona fide LRRK2 substrate, Rab GTPases, in LRRK2 pathway regulation as well as downstream events in the autophagy and inflammatory pathways. Correspondence: Malú G...
Biochem Soc Trans (2019) 47 (2): 639–650.
Published: 05 March 2019
... of genetic and cell biological studies in humans and in mice have helped illuminate the major membrane trafficking pathways in osteoclasts and unmask the core molecular machinery that governs these distinct vesicle transport routes. Among these, small Rab GTPases, their binding partners and members...
Biochem Soc Trans (2018) 46 (3): 683–690.
Published: 21 May 2018
... GDP-bound conformations. Despite possessing a slow intrinsic GTP hydrolysis activity, Rab proteins rely on RabGAPs (Rab GTPase-activating proteins) that catalyze GTP hydrolysis and consequently inactivate the respective Rab GTPases. Two related RabGAPs, TBC1D1 and TBC1D4 (=AS160) have been described...
Biochem Soc Trans (2016) 44 (6): 1603–1610.
Published: 02 December 2016
... 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 autophagy Golgi human genetics kinase Rab GTPases vesicles In 2004, mutations were found in the leucine-rich repeat kinase 2 ( LRRK2 ) gene that caused an autosomal dominant form...