... of Rab GTPases and its various cellular consequences in vitro and in the intact brain, and we will highlight major outstanding questions in the field. Correspondence: Sabine Hilfiker ( [email protected] ) LRRK2 phosphorylation requires the Rab proteins to be membrane-bound and GTP...

... 11 2016 11 11 2016 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 GDI GEF leucine-rich repeat kinase Rab protein REP vesicular trafficking Since steady-state phosphorylation levels of a protein are the result...

... phosphorylation Rab protein vesicle transport Parkinson's disease (PD) is a common neurodegenerative disorder of largely unknown aetiology, with ageing as a major risk factor [ 1 ]. Over a decade ago, mutations in the Leucine-Rich Repeat kinase 2 ( LRRK2 ) gene were reported to cause autosomal...

... neurodegeneration remain unclear. LRRK2 seems to regulate a variety of intracellular vesicular trafficking events to and from the late endosome in a manner dependent on various Rab proteins. At least some of those events are further regulated by LRRK2 in a manner dependent on two-pore channels (TPCs). TPCs...

.... However, attempts to classify the encoded protein on the basis of phylogeny and active conformation have not provided any clues as to its function [ 17 , 28 ]. It has been suggested in the literature that Rab18 is one of a group of Rab proteins with a putative exocytotic role [ 29 , 30 ]. However...

... kinase 2 (LRRK2) nicotinic acid–adenine dinucleotide phosphate (NAADP) Parkinson's disease Rab protein 1 To whom correspondence should be addressed (email [email protected] ). The effects of LRRK2 on autophagic–lysosomal clearance may reflect its primary mechanism...

... endosomal sorting motor protein Rab protein sorting nexin (SNX) Eukaryotic cells are compartmentalized into distinct organelles that are composed of specific cohorts of proteins and lipids. Precise transport mechanisms are therefore required to direct molecules to the right compartment...

...–Tooth disease endocytosis neurite outgrowth neurodegeneration Rab7 Rab protein The CMT disease (Charcot–Marie–Tooth disease) is one of the most common groups of inherited neuropathies that affect peripheral nerves [ 1 ]. Peripheral nerves connect the brain and spinal cord to muscles...

... protein lysosomal storage disease Rab protein sterol transport Endosomes receive cholesterol from two major sources: the endocytic pathway is the entry point of lipoprotein-derived cholesterol into the cell, but even in the absence of lipoproteins, membrane cholesterol is continuously recycled...