... review the link between cellular deficits in intracellular trafficking pathways and the LRRK2-mediated phosphorylation of those newly identified substrates. Upon insertion into their target membrane and conversion into their active, GTP-bound form by their respective GEFs, Rab proteins then act upon...

... phosphorylation Rab protein vesicle transport Parkinson's disease (PD) is a common neurodegenerative disorder of largely unknown aetiology, with ageing as a major risk factor [ 1 ]. Over a decade ago, mutations in the Leucine-Rich Repeat kinase 2 ( LRRK2 ) gene were reported to cause autosomal...

... neurodegeneration remain unclear. LRRK2 seems to regulate a variety of intracellular vesicular trafficking events to and from the late endosome in a manner dependent on various Rab proteins. At least some of those events are further regulated by LRRK2 in a manner dependent on two-pore channels (TPCs). TPCs...

...-binding proteins J. Mol. Biol. 2001 313 889 901 29 Vázquez-Martínez R. Malagón M.M. Rab proteins and the secretory pathway: the case of Rab18 in neuroendocrine cells Front. Endocrinol. 2011 2 1 30 Wixler V. Wixler L. Altenfeld A. Ludwig S. Goody R.S...

... © 2012 Biochemical Society 2012 calcium signalling endolysosome leucine-rich repeat kinase 2 (LRRK2) nicotinic acid–adenine dinucleotide phosphate (NAADP) Parkinson's disease Rab protein Although the molecular mechanism(s) of LRRK2 function remain unclear, at the cellular level...

... Journal compilation © 2011 Biochemical Society 2011 early endosome endosomal sorting motor protein Rab protein sorting nexin (SNX) Eukaryotic cells are compartmentalized into distinct organelles that are composed of specific cohorts of proteins and lipids. Precise transport mechanisms...

... in view of the fact that Rab7 is a ubiquitous protein. The present review discusses possible molecular mechanisms underlying CMT2B. The number of Rab genes in the human genome is more than 60, whereas in the yeast genome only 11 Rab proteins are codified. The large number of Rabs in humans compared...

... as within endosomal domains requires efficient systems for cholesterol sorting and recycling from different stations. The mechanisms by which this is achieved are beginning to emerge. cholesterol endosomal sterol-binding protein lysosomal storage disease Rab protein sterol transport © 2006...