...John M. O'shea; Neil D. Perkins The RelA (p65) NF-κB (nuclear factor κB) subunit contains an extremely active C-terminal transcriptional activation domain, required for its cellular function. In the present article, we review our knowledge of this domain, its modifications and its known interacting...

... modelling have identified that the timing of cellular responses may play an important role in the regulation of this pathway. p65/RelA (RelA) has been shown to translocate between the nucleus and cytoplasm with varying oscillatory patterns in different cell lines leading to differences in transcriptional...

... total NF-κB inhibition. 1 To whom correspondence should be addressed (email k.j.campbell@dundee.ac.uk ). 5 7 2004 © 2004 The Biochemical Society 2004 chemotherapy nuclear factor κB (NF-κB) post-translational modification RelA transcription UV light NF-κB...

...N.D. Perkins The RelA(p65) NF-κB (nuclear factor κB) subunit is typically thought of as being antiapoptotic and tumour-promoting. However, in our laboratory, we have discovered that RelA can inhibit, rather than induce, antiapoptotic gene expression when activated by certain chemotherapeutic drugs...