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Keyword: Rheb
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Articles
Biochem Soc Trans (2013) 41 (4): 951-955.
Published: 18 July 2013
...Marlous J. Groenewoud; Fried J.T. Zwartkruis mTORC1 (mammalian target of rampamycin complex 1) is a highly conserved protein complex regulating cell growth and metabolism via its kinase mTOR (mammalian target of rapamycin). The activity of mTOR is under the control of various GTPases, of which Rheb...
Articles
Biochem Soc Trans (2009) 37 (1): 217-222.
Published: 20 January 2009
... understood, these phosphorylation events relieve the inhibitory effects of the TSC1–TSC2 complex on Rheb and mTORC1 [mTOR (mammalian target of rapamycin) complex] 1, thereby activating mTORC1 in response to growth factors. Through negative-feedback mechanisms, mTORC1 activity inhibits growth factor...
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Biochem Soc Trans (2009) 37 (1): 223-226.
Published: 20 January 2009
...Joseph Avruch; Xiaomeng Long; Yenshou Lin; Sara Ortiz-Vega; Joseph Rapley; Angela Papageorgiou; Noriko Oshiro; Ushio Kikkawa The signalling function of mTOR complex 1 is activated by Rheb-GTP, which controls the catalytic competence of the mTOR (mammalian target of rapamycin) kinase domain by an...
Articles
Biochem Soc Trans (2009) 37 (1): 289-290.
Published: 20 January 2009
... compilation © 2009 Biochemical Society 2009 amino acid localization mammalian target of rapamycin (mTOR) Ras-related GTPase (Rag) Rheb The mTOR (mammalian target of rapamycin) kinase is an evolutionarily conserved protein that regulates cell growth, survival and metabolism. mTOR participates in...