... the opposing roles of human E3 ligases as effectors and targets in the evolutionary battle between host and pathogen, specifically in the context of SARS-CoV-2 infection. Through complex effects on transcription, translation, and protein trafficking, human E3 ligases can either attenuate SARS-CoV-2 infection...

...Evangelos D. Karousis Non-structural protein 1 (Nsp1) is one of the first proteins produced during coronaviral infections. It plays a pivotal role in hijacking and rendering the host gene expression under the service of the virus. With a focus on SARS-CoV-2, this review presents how Nsp1...

.... Multiple viruses are known to hijack the functions of aaRSs for proviral outcomes, while cells modify antiviral responses through non-canonical functions of certain synthetases. Recent findings have revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent...

...Xiyuan Bai; Tony Schountz; Ashley M. Buckle; Janet L. Talbert; Robert A. Sandhaus; Edward D. Chan Alpha-1-antitrypsin (AAT), a serine protease inhibitor (serpin), is increasingly recognized to inhibit SARS-CoV-2 infection and counter many of the pathogenic mechanisms of COVID-19. Herein, we...

...Huy-Dung Hoang; Parisa Naeli; Tommy Alain; Seyed Mehdi Jafarnejad Interferons (IFNs) are crucial components of the cellular innate immune response to viral infections. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown a remarkable capacity to suppress the host IFN...

... by the participation of University of Liverpool in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. Blood–brain barrier cerebral ischaemia flow disturbances inflammation neurological disorders SARS-CoV-2...

...Holly A. Fryer; Gemma E. Hartley; Emily S.J. Edwards; Robyn E. O'Hehir; Menno C. van Zelm Natural infection with SARS-CoV-2 induces a robust circulating memory B cell (Bmem) population, which remains stable in number at least 8 months post-infection despite the contraction of antibody levels after...

...Kensaku Murano; Youjia Guo; Haruhiko Siomi The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the coronavirus disease (COVID-19) pandemic. As of August 2021, more than 200 million people have been infected with the virus and 4.3 million have lost...

... recently, SARS-CoV-2 (COVID-19). Ivermectin has thus far been tested in Phase III human clinical trials for DENV, while there are currently close to 80 trials in progress worldwide for SARS-CoV-2; preliminary results for randomised clinical trials (RCTs) as well as observational/retrospective studies...

...Anoop Narayanan; Shay A. Toner; Joyce Jose SARS-CoV-2, the coronavirus responsible for the current COVID-19 pandemic, encodes two proteases, 3CL pro and PL pro , two of the main antiviral research targets. Here we provide an overview of the structures and functions of 3CL pro and PL pro and examine...

... of the most recent discoveries made possible by analyses of the SARS-CoV-2 genome. coronavirus RNA structure SARS-CoV-2 RNA viruses represent one of the most common classes of pathogens behind human diseases [ 1 ], with around 180 currently recognized species, and around three new species...

...Dene R. Littler; Bruce J. MacLachlan; Gabrielle M. Watson; Julian P. Vivian; Benjamin S. Gully The race to identify a successful treatment for COVID19 will be defined by fundamental research into the replication cycle of the SARS-CoV-2 virus. This has identified five distinct stages from which...

...Jiayue-Clara Jiang; Yan Zhang The ongoing COVID-19 pandemic has placed an overwhelming burden on the healthcare system, and caused major disruption to the world economy. COVID-19 is caused by SARS-CoV-2, a novel coronavirus that leads to a variety of symptoms in humans, including cough, fever...

...Zhongyi Wang; Yingying Fu; Zhendong Guo; Jiaming Li; Jingjing Li; Hongliang Cheng; Bing Lu; Qiang Sun The coronavirus disease 2019 (COVID-19), caused by a novel virus of the β-coronavirus genus (SARS-CoV-2), has been spreading globally. As of July 2020, there have been more than 17 million cases...

...Spencer J. Williams; Ethan D. Goddard-Borger The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has pushed the health systems of many countries to breaking point and precipitated social distancing measures that have crippled economic activities across the globe. A return to normality is unlikely...