... of protein complexes, competition with ubiquitin to promote DDR factor stability and ubiquitin-dependent degradation or extraction of SUMOylated DDR factors. As SUMO ‘addiction’ in cancer cells is protective to genomic integrity, targeting components of the SUMO machinery to potentiate DNA damaging therapy...

... to be displaced from chromatin. L3MBTL1 is K48 ubiquitinated by RNF8 and extracted by VCP/p97 from chromatin [ 73 ]. This ubiquitination is antagonised by OTUB2, a DUB that is recruited to DSBs and slows L3MBTL1 Ub dependent removal from chromatin. This limits excessive 53BP1 spreading [ 37 , 75 ]. SUMOylation...

... deubiquitylase mass spectrometry proteomics signalling SUMOylation ubiquitins Ubiquitylation is a post-translational modification involving the covalent binding of the small, highly conserved protein ubiquitin, consisting of 76 amino acids, to a target substrate to regulate protein functions...

... of these authors (email [email protected] or [email protected] ). 2 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 adrenal cortex small ubiquitin-related modifier (SUMO) steroidogenesis steroid receptor SUMOylation ubiquitylation Steroid...

... The Authors Journal compilation © 2009 Biochemical Society 2009 deubiquitinase linear ubiquitin lysine linkage NEDDylation phosphorylation SUMOylation ubiquitination There is hardly any protein in the cell that does not encounter a post-translational modification within its lifespan...

...Ana Talamillo; Jonatan Sánchez; Rosa Barrio SUMOylation, a reversible process used as a ‘fine-tuning’ mechanism to regulate the role of multiple proteins, is conserved throughout evolution. This post-translational modification affects several cellular processes by the modulation of subcellular...

... deprivation (hypoxia). Here, we will briefly review the evolving evidence for this pathway in the regulation of a number of metabolic regulators and discuss a possible role for SUMOylation in the regulation of basic metabolic function. Since its introduction into the earth's atmosphere as a by-product...

... © The Authors Journal compilation © 2007 Biochemical Society 2007 chromobox 4 (Cbx4) E3 ligase polycomb 2 protein (Pc2) polycomb repressive complex (PRC) small ubiquitin-related modifier (SUMO)-binding motif (SBM) SUMOylation Regulation of Protein Function by SUMO Modification...

...F.Z. Watts; A. Skilton; J.C.-Y. Ho; L.K. Boyd; M.A.M. Trickey; L. Gardner; F.-X. Ogi; E.A. Outwin SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear...

...Y.-C. Wu; A.F. Deyrieux; V.G. Wilson SUMOylation of viral proteins is widespread and serves to modify or regulate the properties of those proteins. Papillomaviruses are a large group of small DNA viruses that infect the skin, leading to benign lesions (warts) that in some cases can progress...

... enzyme 9)], and substrate modification, through the co-operation of Ubc9 and E3 protein ligases. Work from our laboratory has shown the first example of a viral protein, Gam1, that binds to the E1 heterodimer, inhibiting its function and causing a complete block of the SUMOylation pathway both in vivo...

...B. Guo; S.-H. Yang; J. Witty; A.D. Sharrocks The modification of proteins by SUMO (small ubiquitin-related modifier) conjugation is becoming increasingly recognized as an important regulatory event. Protein SUMOylation can control a whole range of activities, including subcellular localization...

... conjugated to monomeric SUMO, all three SUMO family members are able to multimerize in vitro . In cells, SUMOs have the potential to multimerize via internal consensus sites for SUMOylation that are present in SUMO-2 and SUMO-3. A SUMO-binding motif in Ubc9 (ubiquitin-conjugating enzyme 9) contributes...

... and co-activators have been identified, little is known about the mechanism underlying SUMOylation-elicited transcriptional repression. Here, we summarize that SUMO modification of transcription factors such as androgen receptor, glucocorticoid receptor, Smad4 and CBP [CREB (cAMP-response-element-binding...