...Dhurjhoti Saha; Srinivas Animireddy; Blaine Bartholomew ATP dependent chromatin remodelers have pivotal roles in transcription, DNA replication and repair, and maintaining genome integrity. SWI/SNF remodelers were first discovered in yeast genetic screens for factors involved in mating type...

...Beatriz Monterde; Ignacio Varela SWI/SNF family of chromatin remodeling complexes uses the energy of ATP to change the structure of DNA, playing key roles in DNA regulation and repair. It is estimated that up to 25% of all human cancers contain alterations in SWI/SNF, although the precise molecular...

... will show examples of these from primarily the INO80/SWR1, SWI/SNF and ISWI/CHD families of remodelers. Figure 2. Modes of regulation for ATP-dependent chromatin remodelers. ( A ) The basic properties of ATP hydrolysis and DNA translocation can be either up- or down-regulated to control the extent...

... reorganization. In the yeast, Saccharomyces cerevisiae , two of the most well-studied macromolecular complexes that perform these epigenetic changes are the ATP-dependent Swi/Snf chromatin-remodelling complex and the SAGA histone acetyltransferase complex. To understand fully the mechanism by which these large...