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Keywords: T cells
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Articles
Biochem Soc Trans (2019) 47 (4): 1077–1089.
Published: 27 June 2019
...Anchi S. Chann; Sarah M. Russell In T cell development, a pivotal decision-making stage, termed β-selection, integrates a TCRβ checkpoint to coordinate survival, proliferation and differentiation to an αβ T cell. Here, we review how transcriptional regulation coordinates fate determination in early...
Articles
Biochem Soc Trans (2018) 46 (2): 391–401.
Published: 14 March 2018
...Lisa M. Ebert; Wenbo Yu; Tessa Gargett; Michael P. Brown Chimeric antigen receptor (CAR)-T cell therapy has been clinically validated as a curative treatment for the difficult to treat malignancies of relapsed/refractory B-cell acute lymphoblastic leukaemia and lymphoma. Here, the CAR-T cells are...
Articles
Biochem Soc Trans (2017) 45 (2): 563–570.
Published: 13 April 2017
...Benoit P. Nicolet; Fiamma Salerno; Monika C. Wolkers T cells release ample amounts of cytokines during infection. This property is critical to prevent pathogen spreading and persistence. Nevertheless, whereas rapid and ample cytokine production supports the clearance of pathogens, the production...
Articles
Biochem Soc Trans (2015) 43 (6): 1201–1207.
Published: 27 November 2015
...Fiamma Salerno; Monika C. Wolkers Cytotoxic T-cells are crucial to protect us from intracellular pathogens and malignant cells. When T-cells become activated, they rapidly secrete cytokines, chemokines and cytotoxic granules that are critical to clear infected cells. However, when not properly...
Articles
Biochem Soc Trans (2003) 31 (2): 457–461.
Published: 01 April 2003
... remodelling, whereby clonotypical immunity deteriorates, while ancestral, innate immunity is largely preserved. (ii) Continuous exposure to antigens causes a lifelong, chronic antigenic stress, which is responsible, together with the involution of the thymus, for the accumulation of memory/effector T cells...
Articles
Biochem Soc Trans (2000) 28 (2): 250–254.
Published: 01 February 2000
... cancers. Laboratory investigations reveal age-related changes in the peripheral T cell pool, in the predominant phenotype, cytokine production profiles, signalling function and in replicative ability following stimulus with antigen, mitogens or anti-CD3 antibody. These changes in the properties of...
Articles
Biochem Soc Trans (1993) 21 (3): 289S.
Published: 01 August 1993
...CLARA G.H. BELL © 1993 Biochemical Society 1993 T cells 646th Meeting Glasgow: 646th Meeting held at the University of Leeds, 30 March–2 April 1993 lntnepithelinl tissues as specific sites lor the y b T cells CLARA G.H. BELL UIC Wl.Med. at Chicago, Microbidogy, M/C 790 Chicago...