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Keywords: T-cell receptor (TCR)
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Articles

Protein tyrosine phosphatases as negative regulators of the immune response

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G.M. Dolton, J.G. Sathish, R.J. Matthews
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1041–1045.
https://doi.org/10.1042/BST0341041
Published: 25 October 2006
... ). 3 8 2006 © 2006 The Biochemical Society 2006 autoimmune disease CD45 Lyp protein tyrosine phosphatase Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1) T-cell receptor (TCR) APC antigen-presenting cell BCR B-cell receptor CSF colony...
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Articles

Regulation of Ras in lymphocytes: get a GRP

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J.C. Stone
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 858–861.
https://doi.org/10.1042/BST0340858
Published: 25 October 2006
... (RasGRP) T-cell receptor (TCR) Ras proteins cycle between GDP-bound ‘off’ and GTP-bound ‘on’ states and serve to link membrane receptor signals to internal effector pathways. The level of active Ras-GTP is controlled by the rates of guanine nucleotide exchange and of GTP hydrolysis. The intrinsic...
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