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Keywords: Vac14
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Biochem Soc Trans (2016) 44 (1): 185–190.
Published: 09 February 2016
... precursor protein (APP), the central molecule in Alzheimer's disease aetiology, as a novel interaction partner of a subunit of the PIKfyve complex, Vac14. Furthermore, it has been shown that APP modulates PIKfyve function and PI(3,5) P 2 dynamics, suggesting that the APP gene family functions as regulator...
Biochem Soc Trans (2016) 44 (1): 177–184.
Published: 09 February 2016
... 4 lysosome neurodegeneration PIKfyve Vac14 Fab1–PIKfyve is the sole lipid kinase that synthesizes PI(3,5)P 2 from phosphatidylinositol-3-phosphate (PI(3) P ) [ 6 , 9 , 10 ]. Fab1 was identified in the budding yeast S. cerevisiae [ 11 ] and was shown to function as a vacuolar PI(3) P...