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Keywords: Winnie
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Articles
Intestinal secretory cell ER stress and inflammation
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 1081–1085.
Published: 20 July 2011
... in Winnie mice in which ER stress arises due to a single missense mutation in the MUC2 mucin produced by intestinal goblet cells. This model has allowed us to explore the genesis of inflammation ensuing from a single gene polymorphism affecting secretory cells. In these mice, a proportion of MUC2 misfolds...
