...Lei Shi; Benjamin P. Tu Protein acetylation has emerged as a prominent post-translational modification that can occur on a wide variety of proteins. The metabolite acetyl-CoA is a key intermediate in energy metabolism that also serves as the acetyl group donor in protein acetylation modifications...

.... In addition, the CoA ester malonyl-CoA has an important role in regulating fatty acid oxidation, secondary to inhibiting CPT (carnitine palmitoyltransferase) 1, a key enzyme involved in mitochondrial fatty acid uptake. Alterations in malonyl-CoA synthesis by ACC (acetyl-CoA carboxylase) and degradation by MCD...

...Abdussalam Adina-Zada; Tonya N. Zeczycki; Martin St. Maurice; Sarawut Jitrapakdee; W. Wallace Cleland; Paul V. Attwood The activity of the biotin-dependent enzyme pyruvate carboxylase from many organisms is highly regulated by the allosteric activator acetyl-CoA. A number of X-ray crystallographic...

...% during seedling development. Levels of acetyl-CoA were higher in acn1 compared with wild-type, which is counterintuitive to the activity of ACN1 as a peroxisomal acetyl-CoA synthetase. We hypothesize that ACN1 recycles free acetate to acetyl-CoA within peroxisomes in order that carbon remains fed...

... molecule that controls myocardial fatty acid oxidation is malonyl-CoA, which inhibits uptake of fatty acids into the mitochondria. The levels of malonyl-CoA in the heart are controlled both by its synthesis and degradation. Three enzymes, namely AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase...

... dehydrogenase complex o 2 max, maximal oxygen consumption acetylcamitine acetyl-CoA pyruvate dehydrogenase complex skeletal muscle Skeletal Muscle Energetics and Exercise Tolerance I I I 2 13 14 15 16 17 18 19 Pond, C. M. and Mattacks, C. A. (2002) Cytokine, MacQueen, H. A. and Pond, C. M...

...B. Fatland; M. Anderson; B. J. Nikolau; E. S. Wurtele ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA. Our molecular characterizations of the cDNAs and genes coding for the Arabidopsis ACL indicate that the plant enzyme...