... set of conformational changes induced by ligand-mediated receptor dimerization that result in activation of the intracellular kinase domains. A fundamental understanding of these mechanisms in the MET receptor remains incomplete, despite decades of research. This is due in part to the complex...

... of these occurrences, whereas partial agonists stabilize a contraction of the binding pocket but not the rotamer change of serine (5.46). It is likely that subtle changes in the interactions between transmembrane helix 5 (H5) and H3/H4 on agonist binding promote the formation of the activated state. 1...

.... 1 To whom correspondence should be addressed (email [email protected] ). 1 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 activation Archaea DNA binding operator repression transcription regulation BRE factor B recognition element...

... signalling with other receptors. 1 To whom correspondence should be addressed (email [email protected] ). 9 7 2004 © 2004 The Biochemical Society 2004 activation adhesion conformation cytoskeleton integrin signalling In mammals, 18 α- and 8 β-integrin genes...

... be triggered both from the inside of the cell (resulting in acquisition of ligand-competent conformers) and from the outside (ligand-induced signalling). In this paper, these processes will be described and distinguished by the terms priming and activation, respectively. Although both clustering...