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Keywords: activation
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Biochem Soc Trans (2021) 49 (2): 645–661.
Published: 16 April 2021
... set of conformational changes induced by ligand-mediated receptor dimerization that result in activation of the intracellular kinase domains. A fundamental understanding of these mechanisms in the MET receptor remains incomplete, despite decades of research. This is due in part to the complex...
Biochem Soc Trans (2013) 41 (1): 159–165.
Published: 29 January 2013
... of these occurrences, whereas partial agonists stabilize a contraction of the binding pocket but not the rotamer change of serine (5.46). It is likely that subtle changes in the interactions between transmembrane helix 5 (H5) and H3/H4 on agonist binding promote the formation of the activated state. 1...
Biochem Soc Trans (2013) 41 (1): 326–331.
Published: 29 January 2013
... 2013 activation Archaea DNA binding operator repression transcription regulation Micro-organisms respond efficiently to ever-continuing changing environmental conditions by a combination of transcriptional, translational and metabolic regulation. At the level of gene transcription...
Biochem Soc Trans (2004) 32 (5): 822–825.
Published: 26 October 2004
... signalling with other receptors. 1 To whom correspondence should be addressed (email martin.humphries@man.ac.uk ). 9 7 2004 © 2004 The Biochemical Society 2004 activation adhesion conformation cytoskeleton integrin signalling In mammals, 18 α- and 8 β-integrin genes...
Biochem Soc Trans (2004) 32 (3): 407–411.
Published: 01 June 2004
... be triggered both from the inside of the cell (resulting in acquisition of ligand-competent conformers) and from the outside (ligand-induced signalling). In this paper, these processes will be described and distinguished by the terms priming and activation, respectively. Although both clustering...