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Keyword: adenylate cyclaseClose
Biochem Soc Trans (2019) BST20190227.
Published: 26 November 2019
... © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 A kinase anchoring protein adenylate cyclase cAMP cardiac arrhythmia cardiomyocytes molecular scaffolds Adenylyl cyclases (ACs) generate cAMP from ATP in response to hormone stimulation...
Biochem Soc Trans (2014) 42 (2): 239-243.
Published: 20 March 2014
...Markus Milde; Ruth C. Werthmann; Kathrin von Hayn; Moritz Bünemann A wide variety of G-protein-coupled receptors either activate or inhibit ACs (adenylate cyclases), thereby regulating cellular cAMP levels and consequently inducing proper physiological responses. Stimulatory and inhibitory G...
Biochem Soc Trans (2012) 40 (1): 147-152.
Published: 19 January 2012
...Colin W. Taylor; Stephen C. Tovey PTHR1 (type 1 parathyroid hormone receptors) mediate the effects of PTH (parathyroid hormone) on bone remodelling and plasma Ca 2+ homoeostasis. PTH, via PTHR1, can stimulate both AC (adenylate cyclase) and increases in [Ca 2+ ] i (cytosolic free Ca 2...
Biochem Soc Trans (2007) 35 (5): 1032-1034.
Published: 25 October 2007
...M.J. Cann Cyclic nucleotide PDEs (phosphodiesterases) regulate cellular levels of cAMP and cGMP by controlling the rate of degradation. Several mammalian PDE isoforms possess N-terminal GAF (found in cGMP PDEs, Anabaena adenylate cyclases and Escherichia coli FhlA; where FhlA is formate hydrogen...
Biochem Soc Trans (2006) 34 (4): 492-494.
Published: 21 July 2006
...S. Sayner; T. Stevens Within pulmonary microvascular endothelial cells, activation of endogenous adenylate cyclase generates tightly regulated cAMP transitions in the subplasma membrane space. These cAMP fluxes strengthen contacts between adjacent cells to tighten their barrier function. However...
Biochem Soc Trans (2005) 33 (6): 1319-1322.
Published: 26 October 2005
... presentation, current developments on the targeting and assembly of ACs (adenylate cyclases) and their delivery to selected raft or non-raft domains of the plasma membrane will be discussed, along with the susceptibility of raft-targeted ACs to very discrete modes of increases in the intracellular Ca 2...
Biochem Soc Trans (2005) 33 (6): 1337-1340.
Published: 26 October 2005
...Y. Ishikawa; K. Iwatsubo; T. Tsunematsu; S. Okumura Adenylate cyclase is a membrane-bound enzyme that catalyses the conversion of ATP into cAMP upon activation of cell-surface G-protein-coupled receptors, such as β-adrenergic receptors, and initiates a cascade of phosphorylation reactions within...
Biochem Soc Trans (2005) 33 (1): 257-260.
Published: 01 February 2005
...C.S. Hoffman The fission yeast Schizosaccharomyces pombe primarily detects glucose via a cAMP-signalling pathway. Components of this pathway include the Git3 G-protein-coupled receptor and a heterotrimeric G-protein, from which the Gpa2 Gα subunit activates adenylate cyclase (Git2/Cyr1). Three...
Biochem Soc Trans (2003) 31 (5): 912-915.
Published: 01 October 2003
...D.M.F. Cooper Calcium-sensitive adenylate cyclases provide a key regulatory device for integrating the activities of the two major signalling systems, Ca 2+ and cAMP. Recent experiments have brought us closer to understanding the molecular mechanisms whereby Ca 2+ either stimulates or inhibits...