... that the capacity of adipose tissue to safely store fat may be vital. This paper explores some of the evidence suggesting that the risk of developing metabolic disturbances is not related to how much fat an individual has, but how well their fat can expand to accommodate the caloric excess. If this is true...

... compilation © 2007 Biochemical Society 2007 adipose tissue cytokine diabetes insulin resistance interleukin skeletal muscle The Centre of Inflammation and Metabolism is supported by a grant from the Danish National Research Foundation (DG 02-512-555); the Copenhagen Muscle Research Centre...

... or FPLD1. Its genetic origin is unknown [ 1 ]. 1 To whom correspondence should be addressed (email [email protected] ). 28 6 2005 © 2005 The Biochemical Society 2005 adipose tissue antiretroviral therapy (ART) insulin lamin lipodystrophy pathology...

...S.W. Coppack This review gives a broad description of some of the changes in adipose tissue seen in obesity. There are multiple changes in adipose tissue in obesity: histological, neural and vascular, relating to lipid and carbo-hydrate metabolism and to adipose tissue's endocrine functions. Some...

...P. Trayhurn; I.S. Wood White adipose tissue (WAT) is a major endocrine and secretory organ, which releases a wide range of protein signals and factors termed adipokines. A number of adipokines, including leptin, adiponectin, tumour necrosis factor α, IL-1β (interleukin 1β), IL-6, monocyte...

...F. Karpe; G.D. Tan Insulin resistance is often seen as a consequence of obesity and there are several possible links between adipose tissue function and insulin resistance determined in other organs such as skeletal muscle or liver. One such link is the regulation of NEFA (non-esterified fatty acid...

... metabolism. To test this, we examined mRNA levels for the three PPAR isoforms in tissues of WT (wild-type) and CD36-deficient mice following the administration of saline, glucose or olive oil by intragastric gavage. Compared with WT mice, CD36-null mice had 5–10-fold increased PPAR mRNA in adipose tissue...

...M. Guerre-Millo It is now recognized that the WAT (white adipose tissue) produces a variety of bioactive peptides, collectively termed ‘adipokines’. Alteration of WAT mass in obesity or lipoatrophy affects the production of most adipose secreted factors. Since both conditions are associated...

... tolerance tests suggest that HSL-null mice are insulin resistant. Liver, adipose tissue and skeletal muscle appear all to be sites of impaired insulin sensitivity in HSL-null mice. 1 e-mail [email protected] 679th Meeting of the Biochemical Society held at the University of Essex...

...J. Kopecký; M. Rossmeisl; P. Flachs; K. Bardová; P. Brauner Metabolism of white adipose tissue is involved in the control of body fat content. In vitro experiments indicated a dependence of lipogenesis on mitochondrial ATP production, as well as a reciprocal link between hormonal effects...

...T. Stephenson; H. Budge; A. Mostyn; S. Pearce; R. Webb; M. E. Symonds During late gestation, the maturation of fetal adipose tissue is geared towards the synthesis of high levels of uncoupling protein 1 (UCP1), which is unique to brown adipose tissue. At birth, rapid activation of UCP1 ensures...