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Keywords: aging
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Articles
Biomarkers for aging in Caenorhabditis elegans high throughput screening
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1405–1418.
Published: 17 June 2024
...Victoria R. Yarmey; Adriana San-Miguel Aging is characterized by a functional decline in organism fitness over time due to a complex combination of genetic and environmental factors [ 1–4 ]. With an increasing elderly population at risk of age-associated diseases, there is a pressing need...
Articles
Exploring potential developmental origins of common neurodegenerative disorders
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1035–1044.
Published: 25 April 2024
...James P. Catlin; Christine E. Schaner Tooley In the United States, it is now estimated that 6.7 million people over the age of 65 are afflicted by Alzheimer's disease (AD), over 1 million people are living with Parkinson's disease (PD), and over 200 000 have or are at risk for developing...
Articles
Transcriptional control of neural stem cell activity
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 617–626.
Published: 13 March 2024
... importance has been elucidated in NSCs by knockout or overexpression studies. We mainly discuss the transcription factors with roles in the active, quiescent, and rejuvenation states of adult NSCs. aging cell proliferation gene expression and regulation neural stem cells neurogenesis transcription...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (5): 1811–1846.
Published: 01 September 2023
.... Unfortunately, mitophagy declines with age. Many age-associated diseases, including Alzheimer's and Parkinson's, are characterized by the accumulation of damaged mitochondria and oxidative damage. Therefore, activating the mitophagy process with small molecules is an emerging strategy for treating multiple...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1389–1402.
Published: 28 October 2022
...Eric K. F. Donahue; Elizabeth M. Ruark; Kristopher Burkewitz Advances in public health have nearly doubled life expectancy over the last century, but this demographic shift has also changed the landscape of human illness. Today, chronic and age-dependent diseases dominate the leading causes...
Articles
Allostatic load and ageing: linking the microbiome and nutrition with age-related health
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (4): 1165–1172.
Published: 15 August 2019
...Paul G. Shiels; Sarah Buchanan; Colin Selman; Peter Stenvinkel Ageing is a process of decline in physiological function and capability over time. It is an anticipated major burden on societal health-care costs due to an increasingly aged global population. Accelerated biological ageing is a feature...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (4): 997–1003.
Published: 18 July 2019
... and mammals, a pattern of global DNA hypomethylation coupled with increased methylation levels at some specific genomic regions arises at specific developmental stages and in certain abnormal cells, such as mammalian aging cells and cancer cells as well as some plant epigenetic mutants. Here we provide...
Articles
The quantum mitochondrion and optimal health
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1101–1110.
Published: 15 August 2016
... information to enable adaptability, is central to this whole process. Critically, hormesis could improve mitochondrial quantum efficiency, improving the ATP/ROS ratio, whereas inflammation, which is tightly associated with the aging process, might do the opposite. This all suggests that to achieve optimal...
Articles
Translocator protein: pharmacology and steroidogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 572–578.
Published: 03 August 2015
... pharmacological tools and leads for therapeutics 14-3-3 proteins adrenal aging brain cholesterol gonads hypercortisolism hypogonadism mitochondria steroidogenesis translocator protein (TSPO) voltage-dependent anion channel (VDAC) This work was supported by the Canadian Institutes of Health...
Articles
Redox-based regulation of neural stem cell function and Nrf2
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 627–631.
Published: 03 August 2015
... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...
Articles
CD8 + T-cell senescence: no role for mTOR
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 734–739.
Published: 03 August 2015
...Sian M Henson Aging is accompanied by immune decline leading to increased incidence of infections and malignancies, given the demographic shift of humans towards an older age the identification of strategies for the manipulation of immunity is an important goal. Evidence implicates mammalian target...
Articles
About the dangers, costs and benefits of living an aerobic lifestyle
Available to PurchaseDaniela Knoefler, Lars I.O. Leichert, Maike Thamsen, Claudia M. Cremers, Dana Reichmann, Michael J. Gray, Wei-Yun Wholey, Ursula Jakob
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 917–921.
Published: 11 August 2014
... of quantitative tools that reveal extensive redox-sensitive processes in bacteria and eukaryotes, and (iii) the discovery of a link between early exposure to oxidants and aging. Our future research programme aims to generate an integrated and system-wide view of the beneficial and deleterious effects of ROS...
Articles
Application of redox proteomics to skeletal muscle aging and exercise
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 965–970.
Published: 11 August 2014
...Brian McDonagh; Giorgos K. Sakellariou; Malcolm J. Jackson Skeletal muscle represents a physiologically relevant model for the application of redox proteomic techniques to dissect its response to exercise and aging. Contracting skeletal muscles generate ROS (reactive oxygen species) and RNS...
Articles
The biochemical determinants of tissue regeneration
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (3): 607–608.
Published: 22 May 2014
... Biochemical Society 2014 aging biochemistry bioengineering regenerative medicine stem cell tissue regeneration The language of biochemistry is changing. Phrases such as ‘intellectual property space,’ ‘tractable targets’ and ‘clinical trial’ have joined the biochemist's vernacular...
Articles
New insights into skin stem cell aging and cancer
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (3): 663–669.
Published: 22 May 2014
...M. Carmen Ortells; William M. Keyes Adult tissue homoeostasis requires continual replacement of cells that are lost due to normal turnover, injury and disease. However, aging is associated with an overall decline in tissue function and homoeostasis, suggesting that the normal regulatory processes...
Articles
Activity, regulation, copy number and function in the glyoxalase system
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 419–424.
Published: 20 March 2014
..., HAGH (hydroxyacylglutathione hydrolase), has a regulatory p53-response element. Glo1 is linked to healthy aging, obesity, diabetes and diabetic complications, chronic renal disease, cardiovascular disease, other disorders and multidrug resistance in cancer chemotherapy. Mathematical modelling...
Articles
Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1483–1488.
Published: 20 November 2013
... proteins in lysosomes. 1 To whom correspondence should be addressed (email [email protected] ). 2 7 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 aging autophagy chaperone lysosome neurodegeneration proteotoxicity Malfunction...
Articles
Improvement of mitochondrial function and dynamics by the metabolic enhancer piracetam
Available to PurchaseCarola Stockburger, Christopher Kurz, Konrad A. Koch, Schamim H. Eckert, Kristina Leuner, Walter E. Müller
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1331–1334.
Published: 23 September 2013
...Carola Stockburger; Christopher Kurz; Konrad A. Koch; Schamim H. Eckert; Kristina Leuner; Walter E. Müller The metabolic enhancer piracetam is used in many countries to treat cognitive impairment in aging, brain injuries, as well as dementia such as AD (Alzheimer's disease). As a specific feature...
Articles
Do age-related changes in DNA methylation play a role in the development of age-related diseases?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 803–807.
Published: 23 May 2013
... of pathological conditions (e.g. cancer), but also already occurs during the normal process of aging. The present review focuses on the methylation changes that occur during healthy aging and during disease development, and the potential links between them. We focus especially on the extent to which...
Articles
Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1042–1046.
Published: 19 September 2012
... as well as impaired dopamine D 2 receptor-mediated functions. Whereas LRRK2 −/− brains are normal, LRRK2 −/− kidneys at 20 months of age develop striking accumulation and aggregation of α-synuclein and ubiquitinated proteins, impairment of the autophagy–lysosomal pathway, and increases in apoptotic cell...
Articles
Reproductive aging: insights from model organisms
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1770–1774.
Published: 21 November 2011
...Alice L. Ye; Needhi Bhalla Aging was once thought to be the result of a general deterioration of tissues as opposed to their being under regulatory control. However, investigations in a number of model organisms have illustrated that aspects of aging are controlled by genetic mechanisms...
Articles
In vitro pathological modelling using patient-specific induced pluripotent stem cells: the case of progeria
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1775–1779.
Published: 21 November 2011
...Xavier Nissan; Sophie Blondel; Marc Peschanski Progeria, also known as HGPS (Hutchinson–Gilford progeria syndrome), is a rare fatal genetic disease characterized by an appearance of accelerated aging in children. This syndrome is typically caused by mutations in codon 608 (C1804T) of the gene...
Articles
Defective DNA-damage repair induced by nuclear lamina dysfunction is a key mediator of smooth muscle cell aging
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1780–1785.
Published: 21 November 2011
...Derek T. Warren; Catherine M. Shanahan Accumulation of DNA damage is a major driving force of normal cellular aging and has recently been demonstrated to hasten the development of vascular diseases such as atherosclerosis. VSMCs (vascular smooth muscle cells) are essential for vessel wall integrity...
Articles
Mitochondrial quality control in aging and lifespan control of the fungal aging model Podospora anserina
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1488–1492.
Published: 21 September 2011
...Heinz D. Osiewacz Aging of biological systems is a fundamental process controlled by a complex network of molecular pathways. In the filamentous fungus Podospora anserina , a model in which organismal aging can conveniently be analysed, mitochondria play a central role. A wide range of relevant...
Articles
Mitochondrial dynamics in yeast cell death and aging
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1520–1526.
Published: 21 September 2011
...Ralf J. Braun; Benedikt Westermann Mitochondria play crucial roles in programmed cell death and aging. Different stimuli activate distinct mitochondrion-dependent cell death pathways, and aging is associated with a progressive increase in mitochondrial damage, culminating in oxidative stress...
Articles
Modelling early responses to neurodegenerative mutations in mice
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 933–938.
Published: 20 July 2011
..., we discuss the further contributions that knockin and similar approaches can make to understanding pathogenesis and how best to model disorders of aging in a short-lived mammal. 1 To whom correspondence should be addressed (email [email protected] ). 6 5 2011 ©...
Articles
Impairment of the activity of the plasma membrane Ca 2+ -ATPase in Alzheimer's disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (3): 819–822.
Published: 20 May 2011
...Ana M. Mata; María Berrocal; M. Rosario Sepúlveda AD (Alzheimer's disease) is an age-associated neurodegenerative disorder where the accumulation of neurotoxic Aβ (amyloid β-peptide) in senile plaques is a typical feature. Recent studies point out a relationship between Aβ neurotoxicity and Ca 2...
Articles
A longer and healthier life with TOR down-regulation: genetics and drugs
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (2): 460–465.
Published: 22 March 2011
... with a pharmacological inhibitor of the TOR pathway, rapamycin, can replicate those findings and improve aging in a variety of model organisms. The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance. 1 Correspondence...
Articles
Alzheimer's disease and amyloid β-peptide deposition in the brain: a matter of ‘aging’?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 539–544.
Published: 22 March 2010
...Maria Luisa Moro; Matthew J. Collins; Enrico Cappellini Biomolecules can experience aging processes that limit their long-term functionality in organisms. Typical markers of protein aging are spontaneous chemical modifications, such as AAR (amino acid racemization) and AAI (amino acid isomerization...
Articles
A novel function of lipid droplets in regulating longevity
Available to PurchaseAlexander A. Goldberg, Simon D. Bourque, Pavlo Kyryakov, Tatiana Boukh-Viner, Christopher Gregg, Adam Beach, Michelle T. Burstein, Gayane Machkalyan, Vincent Richard, Sonia Rampersad, Vladimir I. Titorenko
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (5): 1050–1055.
Published: 21 September 2009
.... We summarize the evidence in support of the essential role that LDs play in longevity regulation and propose several molecular mechanisms by which these dynamic organellar compartments control the aging process in multicellular eukaryotes and yeast. It should be emphasized that fatty acid β...
Articles
Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 819–823.
Published: 22 July 2009
... established and are key to our understanding of the pathogenic mechanisms in COPD and may be important for the development of new therapies. There is a relationship between chronic inflammatory diseases and aging, and the processes involved in aging may provide a novel mechanism in the pathogenesis of COPD...
Articles
DNA Damage: from Causes to Cures
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (3): 479–481.
Published: 20 May 2009
... pathways is important for maintaining a balance between increased prevalence of cancer or early onset of aging. The link to aging is becoming greater, and Jan Hoeijmakers (Erasmus Medical Center, Rotterdam, The Netherlands) highlighted that DNA repair is important in determining the rate at which natural...
Articles
Neuroinflammatory changes increase the impact of stressors on neuronal function
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 303–307.
Published: 20 January 2009
...Alessia Piazza; Marina A. Lynch In the last few years, several research groups have reported that neuroinflammation is one feature common to several neurodegenerative diseases and that similar, although perhaps less profound, neuroinflammatory changes also occur with age. Age is the greatest risk...
Articles
Biochemistry and functional significance of collagen cross-linking
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 849–852.
Published: 25 October 2007
...-linking, leading to an understanding of how intracellular collagen-modifying enzymes affect the patterns of cross-links produced. An important distinction is made between the enzyme-mediated cross-linking, essential for optimum tissue function, and the non-enzymatic aging processes that generally lead...
Articles
F-actin cytoskeletal organization in intervertebral disc health and disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 683–685.
Published: 20 July 2007
.... White I.R. Roberts S. Urban J.P. J. Anat. 1998 192 369 378 11 Pritchard S. Guilak F. Ann. Biomed. Eng. 2004 32 103 111 IVD (intervertebral disc) degeneration, the leading cause of age-related chronic axial low back pain [ 1 ], results in a dramatic change...
Articles
The aggravating role of the ubiquitin–proteasome system in neurodegenerative disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 743–745.
Published: 25 October 2006
...C.-C. Hung; E.J. Davison; P.A. Robinson; H.C. Ardley Intraneuronal inclusion bodies are key pathological features of most age-related neurodegenerative disorders including Parkinson's disease and Alzheimer's disease. These inclusions are commonly characterized both by the presence of ubiquitinated...
Articles
Intra-allelic mutation at human telomeres
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (4): 581–582.
Published: 21 July 2006
... of this evidence and the putative mechanisms of intra-allelic telomeric mutation. 1 To whom correspondence should be addressed (email [email protected] ). 29 3 2006 © 2006 The Biochemical Society 2006 aging cancer intra-allelic mutation recombination telomerase telomere...
Articles
A role for actin in aging and apoptosis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1260–1264.
Published: 26 October 2005
...C.W. Gourlay; K.R. Ayscough The actin cytoskeleton is central to many cell processes including membrane trafficking and generation of cell polarity. We have identified a role for actin in cell death and in promoting longevity of the budding yeast, Saccharomyces cerevisiae . Aging in yeast appears...
Articles
Folate and DNA methylation during in utero development and aging
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1006–1007.
Published: 26 October 2004
...J.A. McKay; E.A. Williams; J.C. Mathers DNA methylation is one of several epigenetic mechanisms that play a regulatory role in genome programming and imprinting during embryogenesis. Aberrant DNA methylation has been implicated in the pathogenesis of a number of diseases associated with aging...
Articles
Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-α-lipoic acid
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1447–1449.
Published: 01 December 2003
...A.R. Smith; T.M. Hagen Aging is the single largest risk factor for cardiovascular diseases, which in turn are the leading cause of death of individuals over the age of 65 years. In part, this risk is due to a profound loss of vasomotor function of the major conduit arteries, primarily because...
Articles
Oxidative stress and aging – the use of superoxide dismutase/catalase mimetics to extend lifespan
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1305–1307.
Published: 01 December 2003
... development or adulthood. These findings have demonstrated that pharmacological intervention in the aging process is possible and that these compounds can provide important information about the underlying mechanisms. To date, such interventions have targeted known processes rather than screening compound...
Articles
Skeletal muscles of aged male mice fail to adapt following contractile activity
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (2): 455–456.
Published: 01 April 2003
...A. Vasilaki; L.M Iwanejko; F. McArdle; C.S. Broome; M.J. Jackson; A. McArdle Skeletal muscle adapts rapidly following exercise by the increased production of heat-shock proteins (HSPs). The aim of this study was to examine the ability of muscle from adult and aged mice to produce HSPs following non...
Articles
A study of mitochondrial DNA mutations in peripheral lymphocytes in an aging cohort
Available to PurchaseB. Zhang, S. Ye, A.A. Sayer, S.R. Hammans, S. Adio, L.J. Hinks, P.J. Smythe, D. Groot, C. Cooper, I.N.M. Day
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (2): 444–446.
Published: 01 April 2003
...B. Zhang; S. Ye; A.A. Sayer; S.R. Hammans; S. Adio; L.J. Hinks; P.J. Smythe; D. Groot; C. Cooper; I.N.M. Day Somatic mutation in the mitochondrial genome occurs much more rapidly than in the nuclear genome and is a feature, possibly contributory, of the aging of cells and tissues. Identifying...
Articles
Osteoporosis: pathogenesis and clinical intervention
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (2): 462–464.
Published: 01 April 2003
... for modifying some of the pathogenic processes themselves. In common with other structures, the tissues of the musculoskeletal system undergo many changes with aging, and some of the commonest skeletal disorders are seen in the elderly. The changes in bone lead to osteoporosis and fractures, whereas muscle...
Articles
Effect of age on susceptibility to post-traumatic infection in the elderly
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (2): 449–451.
Published: 01 April 2003
...S.K. Butcher; V. Killampalli; H. Chahal; E. Kaya Alpar; J.M. Lord Previous work has demonstrated an age-related decline in neutrophil function, including a decline in phagocytic capacity, with age in healthy individuals. This decline in function may contribute to increased susceptibility...
Articles
Structure and function of Pet100p, a molecular chaperone required for the assembly of cytochrome c oxidase in Saccharomyces cerevisiae
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (4): 436–441.
Published: 01 August 2001
... Present address: Metropolitan State College of Denver, Department of Biology, Campus Box 53, P. O. Box 173362, Denver, CO 80217-3362, U.S.A. 2 To whom correspondence should be addressed (e-mail [email protected] ) 2 3 2001 © 2001 Biochemical Society 2001 aging...
Articles
Telomere diminution as a cause of immune failure in old age: an unfashionable demurral
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (2): 241–245.
Published: 01 February 2000
...R. A. Miller The hypothesis that cellular proliferation leads to telomere shortening, which in turn leads to replicative failure, which in turn leads to a failure of immune function in aged individuals, is here evaluated against the published evidence about the nature and pace of immune decline...
