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Keywords: aging
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (4): 1165–1172.
Published: 15 August 2019
...Paul G. Shiels; Sarah Buchanan; Colin Selman; Peter Stenvinkel Ageing is a process of decline in physiological function and capability over time. It is an anticipated major burden on societal health-care costs due to an increasingly aged global population. Accelerated biological ageing is a feature...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (4): 997–1003.
Published: 18 July 2019
... and mammals, a pattern of global DNA hypomethylation coupled with increased methylation levels at some specific genomic regions arises at specific developmental stages and in certain abnormal cells, such as mammalian aging cells and cancer cells as well as some plant epigenetic mutants. Here we provide...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1101–1110.
Published: 15 August 2016
... information to enable adaptability, is central to this whole process. Critically, hormesis could improve mitochondrial quantum efficiency, improving the ATP/ROS ratio, whereas inflammation, which is tightly associated with the aging process, might do the opposite. This all suggests that to achieve optimal...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 572–578.
Published: 03 August 2015
... below, the local microenvironment of TSPO may play a greater role in TSPO pharmacology than previously thought. 14-3-3 proteins adrenal aging brain cholesterol gonads hypercortisolism hypogonadism mitochondria steroidogenesis translocator protein (TSPO) voltage-dependent anion channel...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 627–631.
Published: 03 August 2015
... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 734–739.
Published: 03 August 2015
...Sian M Henson Aging is accompanied by immune decline leading to increased incidence of infections and malignancies, given the demographic shift of humans towards an older age the identification of strategies for the manipulation of immunity is an important goal. Evidence implicates mammalian target...
Articles
Daniela Knoefler, Lars I.O. Leichert, Maike Thamsen, Claudia M. Cremers, Dana Reichmann, Michael J. Gray, Wei-Yun Wholey, Ursula Jakob
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 917–921.
Published: 11 August 2014
... of quantitative tools that reveal extensive redox-sensitive processes in bacteria and eukaryotes, and (iii) the discovery of a link between early exposure to oxidants and aging. Our future research programme aims to generate an integrated and system-wide view of the beneficial and deleterious effects of ROS...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 965–970.
Published: 11 August 2014
...Brian McDonagh; Giorgos K. Sakellariou; Malcolm J. Jackson Skeletal muscle represents a physiologically relevant model for the application of redox proteomic techniques to dissect its response to exercise and aging. Contracting skeletal muscles generate ROS (reactive oxygen species) and RNS...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (3): 607–608.
Published: 22 May 2014
... and biomaterials for tissue regeneration, and the regenerative process of aging. To our knowledge, this meeting was the first of its kind to cover all of these diverse themes within a single conference. Highlights of this year's conference covered in this issue of Biochemical Society Transactions include...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (3): 663–669.
Published: 22 May 2014
...M. Carmen Ortells; William M. Keyes Adult tissue homoeostasis requires continual replacement of cells that are lost due to normal turnover, injury and disease. However, aging is associated with an overall decline in tissue function and homoeostasis, suggesting that the normal regulatory processes...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 419–424.
Published: 20 March 2014
..., HAGH (hydroxyacylglutathione hydrolase), has a regulatory p53-response element. Glo1 is linked to healthy aging, obesity, diabetes and diabetic complications, chronic renal disease, cardiovascular disease, other disorders and multidrug resistance in cancer chemotherapy. Mathematical modelling...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1483–1488.
Published: 20 November 2013
... proteins in lysosomes. 1 To whom correspondence should be addressed (email ana-maria.cuervo@einstein.yu.edu ). 2 7 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 aging autophagy chaperone lysosome neurodegeneration proteotoxicity Intracellular...
Articles
Carola Stockburger, Christopher Kurz, Konrad A. Koch, Schamim H. Eckert, Kristina Leuner, Walter E. Müller
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1331–1334.
Published: 23 September 2013
...Carola Stockburger; Christopher Kurz; Konrad A. Koch; Schamim H. Eckert; Kristina Leuner; Walter E. Müller The metabolic enhancer piracetam is used in many countries to treat cognitive impairment in aging, brain injuries, as well as dementia such as AD (Alzheimer's disease). As a specific feature...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 803–807.
Published: 23 May 2013
... of pathological conditions (e.g. cancer), but also already occurs during the normal process of aging. The present review focuses on the methylation changes that occur during healthy aging and during disease development, and the potential links between them. We focus especially on the extent to which...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1042–1046.
Published: 19 September 2012
... as well as impaired dopamine D 2 receptor-mediated functions. Whereas LRRK2 −/− brains are normal, LRRK2 −/− kidneys at 20 months of age develop striking accumulation and aggregation of α-synuclein and ubiquitinated proteins, impairment of the autophagy–lysosomal pathway, and increases in apoptotic cell...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1780–1785.
Published: 21 November 2011
...Derek T. Warren; Catherine M. Shanahan Accumulation of DNA damage is a major driving force of normal cellular aging and has recently been demonstrated to hasten the development of vascular diseases such as atherosclerosis. VSMCs (vascular smooth muscle cells) are essential for vessel wall integrity...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1770–1774.
Published: 21 November 2011
...Alice L. Ye; Needhi Bhalla Aging was once thought to be the result of a general deterioration of tissues as opposed to their being under regulatory control. However, investigations in a number of model organisms have illustrated that aspects of aging are controlled by genetic mechanisms...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1775–1779.
Published: 21 November 2011
...Xavier Nissan; Sophie Blondel; Marc Peschanski Progeria, also known as HGPS (Hutchinson–Gilford progeria syndrome), is a rare fatal genetic disease characterized by an appearance of accelerated aging in children. This syndrome is typically caused by mutations in codon 608 (C1804T) of the gene...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1488–1492.
Published: 21 September 2011
...Heinz D. Osiewacz Aging of biological systems is a fundamental process controlled by a complex network of molecular pathways. In the filamentous fungus Podospora anserina , a model in which organismal aging can conveniently be analysed, mitochondria play a central role. A wide range of relevant...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1520–1526.
Published: 21 September 2011
...Ralf J. Braun; Benedikt Westermann Mitochondria play crucial roles in programmed cell death and aging. Different stimuli activate distinct mitochondrion-dependent cell death pathways, and aging is associated with a progressive increase in mitochondrial damage, culminating in oxidative stress...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 933–938.
Published: 20 July 2011
..., we discuss the further contributions that knockin and similar approaches can make to understanding pathogenesis and how best to model disorders of aging in a short-lived mammal. 1 To whom correspondence should be addressed (email michael.coleman@bbsrc.ac.uk ). 6 5 2011 ©...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (3): 819–822.
Published: 20 May 2011
...Ana M. Mata; María Berrocal; M. Rosario Sepúlveda AD (Alzheimer's disease) is an age-associated neurodegenerative disorder where the accumulation of neurotoxic Aβ (amyloid β-peptide) in senile plaques is a typical feature. Recent studies point out a relationship between Aβ neurotoxicity and Ca 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (2): 460–465.
Published: 22 March 2011
... with a pharmacological inhibitor of the TOR pathway, rapamycin, can replicate those findings and improve aging in a variety of model organisms. The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance. 1 Correspondence...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 539–544.
Published: 22 March 2010
...Maria Luisa Moro; Matthew J. Collins; Enrico Cappellini Biomolecules can experience aging processes that limit their long-term functionality in organisms. Typical markers of protein aging are spontaneous chemical modifications, such as AAR (amino acid racemization) and AAI (amino acid isomerization...
Articles
Alexander A. Goldberg, Simon D. Bourque, Pavlo Kyryakov, Tatiana Boukh-Viner, Christopher Gregg, Adam Beach, Michelle T. Burstein, Gayane Machkalyan, Vincent Richard, Sonia Rampersad, Vladimir I. Titorenko
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (5): 1050–1055.
Published: 21 September 2009
.... We summarize the evidence in support of the essential role that LDs play in longevity regulation and propose several molecular mechanisms by which these dynamic organellar compartments control the aging process in multicellular eukaryotes and yeast. C/EBPα CCAAT/enhancer-binding protein α...
Articles
Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 819–823.
Published: 22 July 2009
... established and are key to our understanding of the pathogenic mechanisms in COPD and may be important for the development of new therapies. There is a relationship between chronic inflammatory diseases and aging, and the processes involved in aging may provide a novel mechanism in the pathogenesis of COPD...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (3): 479–481.
Published: 20 May 2009
.... A particular focus was to report on progress in understanding biochemical details about how DNA repair intersects with cellular pathways that lead to cancer or aging. The meeting was particularly timely since it is now apparent that certain DNA-repair processes offer significant potential for novel therapies...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 303–307.
Published: 20 January 2009
...Alessia Piazza; Marina A. Lynch In the last few years, several research groups have reported that neuroinflammation is one feature common to several neurodegenerative diseases and that similar, although perhaps less profound, neuroinflammatory changes also occur with age. Age is the greatest risk...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 849–852.
Published: 25 October 2007
...-linking, leading to an understanding of how intracellular collagen-modifying enzymes affect the patterns of cross-links produced. An important distinction is made between the enzyme-mediated cross-linking, essential for optimum tissue function, and the non-enzymatic aging processes that generally lead...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 683–685.
Published: 20 July 2007
... 2007 1 To whom correspondence should be addressed (email duance@cardiff.ac.uk ). actin aging cytoskeleton intervertebral disc mechanotransduction IVD (intervertebral disc) degeneration, the leading cause of age-related chronic axial low back pain [ 1 ], results in a dramatic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 743–745.
Published: 25 October 2006
...C.-C. Hung; E.J. Davison; P.A. Robinson; H.C. Ardley Intraneuronal inclusion bodies are key pathological features of most age-related neurodegenerative disorders including Parkinson's disease and Alzheimer's disease. These inclusions are commonly characterized both by the presence of ubiquitinated...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (4): 581–582.
Published: 21 July 2006
... of this evidence and the putative mechanisms of intra-allelic telomeric mutation. 1 To whom correspondence should be addressed (email bairddm@cardiff.ac.uk ). 29 3 2006 © 2006 The Biochemical Society 2006 aging cancer intra-allelic mutation recombination telomerase telomere...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1260–1264.
Published: 26 October 2005
...C.W. Gourlay; K.R. Ayscough The actin cytoskeleton is central to many cell processes including membrane trafficking and generation of cell polarity. We have identified a role for actin in cell death and in promoting longevity of the budding yeast, Saccharomyces cerevisiae . Aging in yeast appears...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1006–1007.
Published: 26 October 2004
...J.A. McKay; E.A. Williams; J.C. Mathers DNA methylation is one of several epigenetic mechanisms that play a regulatory role in genome programming and imprinting during embryogenesis. Aberrant DNA methylation has been implicated in the pathogenesis of a number of diseases associated with aging...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1447–1449.
Published: 01 December 2003
...A.R. Smith; T.M. Hagen Aging is the single largest risk factor for cardiovascular diseases, which in turn are the leading cause of death of individuals over the age of 65 years. In part, this risk is due to a profound loss of vasomotor function of the major conduit arteries, primarily because...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1305–1307.
Published: 01 December 2003
... development or adulthood. These findings have demonstrated that pharmacological intervention in the aging process is possible and that these compounds can provide important information about the underlying mechanisms. To date, such interventions have targeted known processes rather than screening compound...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (2): 455–456.
Published: 01 April 2003
...A. Vasilaki; L.M Iwanejko; F. McArdle; C.S. Broome; M.J. Jackson; A. McArdle Skeletal muscle adapts rapidly following exercise by the increased production of heat-shock proteins (HSPs). The aim of this study was to examine the ability of muscle from adult and aged mice to produce HSPs following non...
Articles
B. Zhang, S. Ye, A.A. Sayer, S.R. Hammans, S. Adio, L.J. Hinks, P.J. Smythe, D. Groot, C. Cooper, I.N.M. Day
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (2): 444–446.
Published: 01 April 2003
...B. Zhang; S. Ye; A.A. Sayer; S.R. Hammans; S. Adio; L.J. Hinks; P.J. Smythe; D. Groot; C. Cooper; I.N.M. Day Somatic mutation in the mitochondrial genome occurs much more rapidly than in the nuclear genome and is a feature, possibly contributory, of the aging of cells and tissues. Identifying...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (2): 462–464.
Published: 01 April 2003
... for modifying some of the pathogenic processes themselves. In common with other structures, the tissues of the musculoskeletal system undergo many changes with aging, and some of the commonest skeletal disorders are seen in the elderly. The changes in bone lead to osteoporosis and fractures, whereas muscle...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (2): 449–451.
Published: 01 April 2003
...S.K. Butcher; V. Killampalli; H. Chahal; E. Kaya Alpar; J.M. Lord Previous work has demonstrated an age-related decline in neutrophil function, including a decline in phagocytic capacity, with age in healthy individuals. This decline in function may contribute to increased susceptibility...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (4): 436–441.
Published: 01 August 2001
... Present address: Metropolitan State College of Denver, Department of Biology, Campus Box 53, P. O. Box 173362, Denver, CO 80217-3362, U.S.A. 2 To whom correspondence should be addressed (e-mail poyton@spot.colorado.edu ) 2 3 2001 © 2001 Biochemical Society 2001 aging...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (2): 241–245.
Published: 01 February 2000
...R. A. Miller The hypothesis that cellular proliferation leads to telomere shortening, which in turn leads to replicative failure, which in turn leads to a failure of immune function in aged individuals, is here evaluated against the published evidence about the nature and pace of immune decline...
