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Keywords: alanine scan
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Biochem Soc Trans (2013) 41 (1): 180–184.
Published: 29 January 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 alanine scan family A GPCRs family B GPCRs mutagenesis secretin-like GPCR structure–activity relationship Family B GPCRs have a number of conserved proline residues, including a proline towards the middle of TM helix 6...
Biochem Soc Trans (2012) 40 (2): 433–437.
Published: 21 March 2012
... that are the natural agonists for these receptors. We have carried out alanine scans on all three ECLs of CLR, as well as their associated juxtamembrane regions. Residues within all three loops influence CGRP binding and receptor activation. Mutation of Ala 203 and Ala 206 on ECL1 to leucine increased the affinity...