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Keywords: alanine scan
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Articles
The activation of the CGRP receptor
Available to PurchaseJames Barwell, Mark Wheatley, Alex C. Conner, Bruck Taddese, Shabana Vohra, Christopher A. Reynolds, David R. Poyner
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 180–184.
Published: 29 January 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 alanine scan family A GPCRs family B GPCRs mutagenesis secretin-like GPCR structure–activity relationship CGRP is an abundant 37-amino-acid neuropeptide that is especially found in the sensory nervous system. CGRP is released...
Articles
The role of the extracellular loops of the CGRP receptor, a family B GPCR
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (2): 433–437.
Published: 21 March 2012
... that are the natural agonists for these receptors. We have carried out alanine scans on all three ECLs of CLR, as well as their associated juxtamembrane regions. Residues within all three loops influence CGRP binding and receptor activation. Mutation of Ala 203 and Ala 206 on ECL1 to leucine increased the affinity...
