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Keywords: allosteric regulation
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Biochem Soc Trans (2024) BST20230358.
Published: 10 June 2024
... GPCR G-protein coupled receptor allosteric regulation biased signaling chemokine receptor G-protein-coupled receptors receptor activation References 1 Schall , T.J. and Proudfoot , A.E.I. ( 2011 ) Overcoming hurdles in developing successful drugs targeting chemokine...
Includes: Supplementary data
Biochem Soc Trans (2023) 51 (3): 1319–1329.
Published: 04 May 2023
... and the Biochemical Society under a transformative agreement with Bibsam. allosteric regulation bacterial transcription regulation diphtheria toxin repressor iron homeostasis iron-dependent regulator metal-sensing transcription factor In the early 1990s the groups of Holmes and Murphy identified...
Biochem Soc Trans (2023) 51 (1): 373–385.
Published: 16 February 2023
... of kinase substrates. Here, we review mechanisms of allosteric regulation of protein kinases and recent advances in the field. Allosteric inhibitors that target protein kinases are of considerable interest for both their potential as therapeutics in human disease and utility as research probes...
Biochem Soc Trans (2022) 50 (6): 1703–1714.
Published: 18 November 2022
... particular conditions, often during nutrient depletion or other types of stress, and their discovery sparked renewed interest in self-assembly of enzymes and its possible involvement in enzyme regulation. allosteric regulation DNA endonuclease enzyme mechanism enzymology filamentation...
Biochem Soc Trans (2022) 50 (1): 71–82.
Published: 22 February 2022
... © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . allosteric regulation retinitis pigmentosa splice variants Inosine...
Biochem Soc Trans (2021) 49 (1): 415–429.
Published: 05 February 2021
... ]. On the other hand, the mechanism of allosteric regulation has only been computationally investigated for chorismate mutase from the yeast species Saccharomyces cerevisiae ( Sce CM) [ 92 ]. Correspondence: Wanting Jiao ( wanting.jiao@vuw.ac.nz ) 25 11 2020 14 1 2021 15 1 2021 ©...
Biochem Soc Trans (2019) 47 (4): 1013–1027.
Published: 11 July 2019
.... In addition, allosteric regulation further fine-tunes the catalytic activity of SAMHD1, with a nucleotide-activated homotetramer as the catalytically active form of the protein. In cells, GTP and dATP are the likely physiological activators of two adjacent allosteric sites, AL1 (GTP) and AL2 (dATP...
Biochem Soc Trans (2019) 47 (1): 381–388.
Published: 01 February 2019
... Liang ( zxliang@ntu.edu.sg ) 14 11 2018 2 1 2019 8 1 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 allosteric regulation cellulose synthase cyclic di-GMP flagella PilZ domain protein–protein interactions...
Biochem Soc Trans (2018) 46 (3): 587–597.
Published: 20 April 2018
... allosteric regulation fractals protein conformation protein dynamics Allostery is a process that regulates the activity of enzymes via binding a modulator at a distal site, sterically different from the chemically active site. It is now well recognized that allostery is a fundamental property...
Biochem Soc Trans (2017) 45 (5): 1087–1095.
Published: 25 August 2017
... Press Limited on behalf of the Biochemical Society 2017 allosteric regulation complex IV conformational change proton pathways The mechanism by which C c O (cytochrome c oxidase) reduces oxygen to water and conserves the free energy released by this reaction in the form of a proton...
Biochem Soc Trans (2017) 45 (3): 665–681.
Published: 15 June 2017
...-catalytic functions that can be exerted by conventional protein kinases. allosteric regulation protein–protein interactions pseudoenzyme pseudokinases signalling Counterparts of active enzymes that lack key catalytic residues and are therefore predicted to possess defective catalytic...
Biochem Soc Trans (2017) 45 (3): 831–837.
Published: 15 June 2017
... of the Biochemical Society 2017 allosteric regulation azobenzene molecular machine photoswitch protein engineering The fundamental basis of the ‘molecular tweezer’ engineering strategy lies in the photo-physical properties of the azobenzene group. It exists in two isomerization states...
Biochem Soc Trans (2014) 42 (1): 108–113.
Published: 23 January 2014
...) and a potential allosteric regulator at the pseudosymmetric site (depicted in white). These cavities are collapsed in the inactive crystal structure ( D ). The catalytic core of sGC is composed of two homologous domains. The active site lies at the interface between the two domains. Ligand binding...
Biochem Soc Trans (2013) 41 (1): 205–212.
Published: 29 January 2013
... for allosteric regulation of GPCRs by sodium ions Science 2012 337 232 236 40 Lebon G. Warne T. Edwards P.C. Bennett K. Langmead C.J. Leslie A.G. Tate C.G. Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation Nature 2011 474 521...
Biochem Soc Trans (2000) 28 (2): 186–190.
Published: 01 February 2000
...,6BP, fructose 1,6-bisphosphate allosteric regulation drug design effector site fructose 2,6-bisphosphate trypanosomatid Biochemical Society Transactions (2000) Volume 28, part 2 acyl-CoA. The enzyme properties and locations are consistent with this. Above all, the carnitine derivatives...